Ezetimibe

By Medically reviewed by hellodoktor

Generic Name: Ezetimibe Brand Name(s): Ezetimibe and Ezetimibe.

Uses

What is Ezetimibe used for?

Ezetimibe is commonly used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. Ezetimibe may be used alone or with other drugs (such as “statins” or fibrates). Ezetimibe works by reducing the amount of cholesterol your body absorbs from your diet. Reducing cholesterol may help prevent strokes and heart attacks.

How should I take Ezetimibe?

Take this medication by mouth as directed by your doctor, usually once daily with or without food.

The dosage is based on your medical condition and response to treatment.

If taking a bile acid sequestrant (such as cholestyramine, colestipol), take ezetimibe at least 2 hours before or 4 hours after taking the bile acid sequestrant. These products may bind to ezetimibe, preventing your body from fully absorbing the drug.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

It is important to continue taking this medication even if you feel well. Most people with high cholesterol do not feel sick. It may take up to 2 weeks before you get the full benefit of this drug.

How do I store Ezetimibe?

Ezetimibe is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Ezetimibe in the bathroom or the freezer. There may be different brands of Ezetimibe that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Ezetimibe down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Ezetimibe?

Before taking ezetimibe, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Ezetimibe during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Ezetimibe. Ezetimibe is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Ezetimibe?

This drug may increase the risk of liver damage (when taken with a “statin”) or muscle damage when taken with a fibrate or “statin”. Tell your doctor right away if you experience any of the following symptoms: signs of liver problems (such as severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine), muscle pain/tenderness/weakness (especially with fever or unusual tiredness).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Ezetimibe?

Ezetimibe may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Ezetimibe?

Ezetimibe may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Ezetimibe?

Ezetimibe may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Ezetimibe.

What is the dose of Ezetimibe for an adult?

Usual Adult Dose for Hyperlipidemia

10 mg orally once a day

Uses:

-For use as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin) as an adjunct to diet to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia

-For use as combination therapy with fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia

-As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia

-For use as combination therapy with atorvastatin or simvastatin to reduce elevated total-C and LDL-C levels in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Adult Dose for Homozygous Familial Hypercholesterolemia

10 mg orally once a day

Uses:

-For use as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin) as an adjunct to diet to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia

-For use as combination therapy with fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia

-As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia

-For use as combination therapy with atorvastatin or simvastatin to reduce elevated total-C and LDL-C levels in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Adult Dose for Sitosterolemia

10 mg orally once a day

Uses:

-For use as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin) as an adjunct to diet to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia

-For use as combination therapy with fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia

-As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia

-For use as combination therapy with atorvastatin or simvastatin to reduce elevated total-C and LDL-C levels in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild liver dysfunction: No adjustment recommended.

Moderate to severe liver dysfunction: Not recommended.

Other Comments

Administration advice:

-Take orally once a day, with or without food

-Take at least 2 hours before or 4 hours after administration of a bile acid sequestrant

-May be taken at same time as the statin or fenofibrate, according to the dosing recommendations for the respective medications

-Consult appropriate manufacturer product information when using this drug in combination with a statin or fenofibrate.

Storage requirements:

-Protect from moisture.

General:

-Therapy with lipid-altering agents should only be a single component of multiple risk factor intervention in patients at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia.

-Drug therapy is indicated as an adjunct to diet when response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has proven inadequate.

-This drug has not been studied in Fredrickson Type I, III, IV, and V dyslipidemias.

Monitoring:

-Hepatic: When used concomitantly with a statin, liver tests should be performed prior to initiating therapy and according to the recommendations of the statin.

-Metabolic: Periodically measure fasting lipid panel.

Patient advice:

-Promptly report any unexplained muscle pain, tenderness, or weakness.

-Adhere to recommended diet, exercise program, and periodic testing of a fasting lipid panel.

What is the dose of Ezetimibe for a child?

Usual Pediatric Dose for Hyperlipidemia

10 years or older: 10 mg orally once a day

Uses:

-For use as monotherapy or in combination with a statin as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia

-For use as combination therapy with a fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia

-As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia

-For use as combination therapy with atorvastatin or simvastatin for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Pediatric Dose for Homozygous Familial Hypercholesterolemia

10 years or older: 10 mg orally once a day

Uses:

-For use as monotherapy or in combination with a statin as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia

-For use as combination therapy with a fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia

-As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia

-For use as combination therapy with atorvastatin or simvastatin for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Usual Pediatric Dose for Sitosterolemia

10 years or older: 10 mg orally once a day

Uses:

-For use as monotherapy or in combination with a statin as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia

-For use as combination therapy with a fenofibrate as an adjunct to diet to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with mixed hyperlipidemia

-As an adjunct to diet to reduce elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia

-For use as combination therapy with atorvastatin or simvastatin for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable

Precautions

Safety and efficacy have not been established in patients younger than 10 years nor in premenarchal girls.

How is Ezetimibe available?

Ezetimibe is available in the following dosage forms and strengths:

  • Oral Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Ezetimibe, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: January 29, 2018 | Last Modified: September 12, 2019

You might also like