What is Etomidate® Lipuro (etomidate) used for?
Etomidate® Lipuro is commonly used for induction of general anesthesia.
How should I take Etomidate® Lipuro (etomidate)?
Etomidate-®Lipuro must be injected strictly intravenously and, as a rule, slowly (a single dose in approx. 30 sec), and fractionated, if required.
Intra-arterial injection must be avoided as there is a danger of Etomidate ® Lipuro to cause necroses if injected intra-arterially. Paravenous injection will cause strong pain.
The use of benzodiazepines is recommended, e. g., diazepam, which may be injected intramuscularly about 1 hour or intravenously 10 min, prior to administration of Etomidate® Lipuro.
In patients with manifest epilepsy or with an increased tendency to convulsions, Etomidate® Lipuro should be injected quickly, i. e. within a few seconds, in order to avoid too slow diffusion of etomidate into the brain.
How do I store Etomidate® Lipuro (etomidate)?
Etomidate® Lipuro is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Etomidate® Lipuro in the bathroom or the freezer. There may be different brands of Etomidate® Lipuro that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.
You should not flush Etomidate® Lipuro down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.
Precautions & warnings
What should I know before using Etomidate® Lipuro (etomidate)?
Etomidate-®Lipuro must not be administered to patients with known hypersensitivity to etomidate or fat emulsions.
It should not be administered to patients with hereditary disorder of hem biosynthesis, unless the indication for administration of etomidate has been definitely established after careful consideration of its potential risks and expected benefits.
Newborns and infants up to the age of 6 months should be excluded from treatment with Etomidate-®Lipuro, except for imperative indications during inpatient treatment.
Etomidate should not be administered to patients with evidence, or suggestion of, reduced adrenocortical function.
Reduced serum cortisol levels, unresponsive to ACTH injections, have been reported in some patients during induction of anesthesia but particularly during maintenance of anesthesia with etomidate; for this reason, etomidate should not be used for maintenance.
However, when etomidate is used for induction, the post-operative rise in serum cortisol which has been observed after thiopentone induction is delayed for approximately 3-6 hours.
In cases of adrenocortical gland dysfunction and during very long surgical procedures, a prophylactic cortisol supplement may be required (for example 50 to 100 mg hydrocortisone). After prolonged continuous administration of etomidate there is a risk of transient adrenocortical failure. Convulsions may occur in unpremedicated patients. In patients with liver cirrhosis, or in those who have already received neuroleptic, opiate or sedative agents, the dose of etomidate should be reduced.
When Etomidate is used, resuscitation equipment should be readily available to manage apnea.
Etomidate should only be given by slow intravenous injection.
Etomidate-®Lipuro has no analgesic effect. If used for short-term narcosis, a strong analgesic, e. g. fentanyl, must be given prior to or simultaneously with Etomidate® Lipuro.
Even when Etomidate-®Lipuro is used as directed, patients having received this drug will not be able to drive or to use machines for at least 24 hours after administration.
Is it safe during pregnancy or breastfeeding?
There isn’t enough information about the safety of using Etomidate® Lipuro during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Etomidate® Lipuro.
What side effects can occur from Etomidate® Lipuro (etomidate)?
Some side effects may occur when using this drug, including:
- Muscle movements (myoclonic)
- A slight and transient drop in blood pressure
- Respiratory depression
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
What drugs may interact with Etomidate® Lipuro (etomidate)?
Etomidate® Lipuro may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Does food or alcohol interact with Etomidate® Lipuro (etomidate)?
Etomidate® Lipuro may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with Etomidate® Lipuro (etomidate)?
Etomidate® Lipuro may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Etomidate® Lipuro (etomidate).
What is the dose of Etomidate® Lipuro (etomidate) for an adult?
As a rule, the effective hypnotic dose is between 0.15 and 0.3 mg of etomidate per kg body weight, corresponding to 0.075 to 0.15 ml of Etomidate ®Lipuro per kg body weight.
Since etomidate has no analgesic action, appropriate analgesics should be used in procedures involving painful stimuli.
Do not exceed a total dose of 30 ml (3 ampoules).
In patients with liver cirrhosis and patients having been premedicated with neuroleptics opioids or sedatives, the dose has to be reduced.
In the special case of narcosis to terminate a status epilepticus or serial epileptic seizures, a sufficient dose of etomidate (0.3 mg/kg body weight, corresponding to 0.15 ml/kg body weight of Etomidate-®Lipuro) should be injected quickly, e.g., within 10 sec. This dose may be repeated several times, if required.
What is the dose of Etomidate® Lipuro (etomidate) for a child?
Children up to the age of 15 and elderly patients are given a single dose of 0.15 to 0.2 mg of etomidate, corresponding to 0.075 to 0.1 ml of Etomidate ®Lipuro per kg body weight.
Also in patients belonging to these age groups, the exact dosage has to be adjusted acc to the clinical effect.
In children up to the age of 15, the dosage may be increased by up to 30 % of the adult dose, because it is sometimes necessary to obtain the same depth and duration of sleep.
How is Etomidate® Lipuro (etomidate) available?
Etomidate® Lipuro is available in the following dosage forms and strengths:
- Etomidate® Lipuro 2 mg/ml
- Emulsion for Injection
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of Etomidate® Lipuro, consult your doctor as soon as possible.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Review Date: April 5, 2017 | Last Modified: September 13, 2019
Etomidate Lipuro. https://www.old.health.gov.il/units/pharmacy/trufot/alonim/ETOMIDATE-LIPURO_dr_1433745808128.pdf. Accessed December 7, 2016
ETOMIDATE-LIPURO 2 MG/ML EMULSION FOR INJECTION. https://www.drugs.com/uk/etomidate-lipuro-2-mg-ml-emulsion-for-injection-leaflet.html. Accessed December 7, 2016.