Etidronate dinatri

By Medically reviewed by hellodoktor

Generic Name: Etidronate dinatri Brand Name(s): Generics only. No brands available.


What is etidronate dinatri used for?

Etidronate dinatri is a bisphosphonate. It works by slowing the resorption of bone and allowing new bone to be formed.

Etidronate dinatri is commonly used for treating Paget’s disease in adult, and preventing and treating abnormal bone growth following hip replacement surgery or spinal cord injury.

It may also be used for other conditions as determined by your doctor.

How should I take etidronate dinatri?

Use etidronate dinatri as directed by your doctor. Ask your health care provider any questions you may have about how to use etidronate.

Take etidronate dinatri with 180 to 240 mL of plain water first in the morning, at least 30 minutes before eating, drinking, or taking any other medicine. Etidronate dinatri works best if taken 60 minutes before eating, drinking, or taking any other medicine. Taking etidronate dinatri with orange juice, coffee, or mineral water may decrease its effectiveness.

Swallow whole. Do not break, crush, suck, or chew the tablet before swallowing.

Do not lie down for at least 30 minutes after taking etidronate dinatri and until after you have had your first meal or snack of the day.

Do not take etidronate dinatri at bedtime or before getting out of bed.

Calcium or iron supplements, vitamins, or antacids containing calcium, magnesium, or aluminum may interfere with the absorption of etidronate. These medicines must be taken at least 2 hours after taking etidronate.

How do I store etidronate dinatri?

Etidronate dinatri is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store etidronate dinatri in the bathroom or the freezer. There may be different brands of etidronate dinatri that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush etidronate dinatri down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using etidronate dinatri?

Before using etidronate dinatri, tell your doctor if:

  • You are allergic to any ingredient in etidronate.
  • You have low blood calcium levels or softening of the bones (osteomalacia).
  • You have esophagus problems, including difficulty swallowing or a narrow or blocked esophagus.
  • You are unable to stand or sit upright for at least 30 minutes.
  • You have had or will be having chemotherapy or radiation treatment

Tell your doctor or dentist that you take etidronate dinatri before you receive any medical or dental care, emergency care, or surgery.

Follow the diet and exercise program given to you by your health care provider. Be sure that you are getting adequate calcium and vitamin D in your diet. Weight-bearing exercise may also be beneficial to increase the calcium density of bones. Consult your doctor or pharmacist for more information.

Etidronate dinatri may cause bone jaw problems in some patients. Your risk may be greater the longer you take etidronate dinatri or if you have cancer, poor dental hygiene, or certain other conditions (e.g., anemia, blood clotting problems, infections, dental problems). Your risk may also be greater if you use certain medicines or therapies (e.g., chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before you start to use etidronate. Ask your doctor any questions you may have about dental treatment while you use etidronate.

Proper dental care is important while you are taking etidronate. Brush and floss your teeth and visit the dentist regularly.

Worsening of asthma has been reported in patients taking medicines like this one. Discuss any questions or concerns with your doctor.

Lab tests, including bone thickness or density and blood calcium levels, may be performed while you use etidronate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Etidronate dinatri should not be used in children; safety and effectiveness in children have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using etidronate dinatri during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking etidronate dinatri. Etidronate dinatri is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from etidronate dinatri?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Constipation
  • Diarrhea
  • Headache
  • Indigestion
  • Mild bone, muscle, or joint pain
  • Mild stomach pain or upset
  • Nausea

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness)
  • Black, bloody, or tarry stools
  • Chest pain
  • Confusion
  • Fever, chills, or persistent sore throat
  • Mental or mood changes (e.g., depression, hallucinations)
  • Mouth sores
  • New, worsening, or severe heartburn
  • Painful or difficult swallowing
  • Red, swollen, blistered, or peeling skin
  • Severe bone, muscle, or joint pain
  • Severe or persistent stomach pain
  • Swelling or pain in your jaw
  • Vomit that looks like coffee grounds

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with etidronate dinatri?

Etidronate dinatri may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with your drug, including:

  • Anticoagulants (e.g., warfarin), because the risk of side effects such as bleeding may be increased.
  • Corticosteroids (e.g., prednisone) or angiogenesis inhibitors (e.g., bevacizumab), because the risk of jawbone problems may be increased.

Does food or alcohol interact with etidronate dinatri?

Etidronate dinatri may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with etidronate dinatri?

Etidronate dinatri may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if any of the following apply to you:

  • A history of stomach or bowel problems (e.g., inflammation, ulcer)
  • Esophagus problems (e.g., narrowing, blockage, heartburn, reflux disease, severe irritation)
  • Kidney problems
  • Difficult or painful swallowing
  • Low blood vitamin D levels
  • Cancer
  • Anemia
  • Asthma
  • Blood clotting problems
  • An infection
  • Calcium metabolism problems
  • Poor dental hygiene or other dental problems, or a dental procedure
  • A mental disorder


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using etidronate dinatri.

What is the dose of etidronate dinatri for an adult?

Heterotopic Ossification Following Total Hip Replacement

The recommended dose is 20 mg/kg/day orally, for 1 mo preoperatively followed by 20 mg/kg/day for 3 mo postoperatively.

Heterotopic Ossification from Spinal Cord Injury

The recommended dose is 20 mg/kg/day orally, for 2 weeks followed by 10 mg/kg/day for 10 weeks; total treatment period is 12 weeks.

Paget Disease

Initial treatment is 5 to 10 mg/kg/day (not to exceed 6 mo) or 11 to 20 mg/kg/day (not to exceed 3 mo), orally.

Reserve dosages greater than 10 mg/kg/day for specific situations.

Max dosage is 20 mg/kg/day.

For re-treatment, initiate only after etidronate-free period of at least 90 days and if there is evidence of active disease.

What is the dose of etidronate dinatri for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is etidronate dinatri available?

Etidronate dinatri is available in the following dosage forms and strengths:

  • Tablets 200 mg
  • Tablets 400 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of etidronate, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: April 5, 2017 | Last Modified: September 12, 2019

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