What is esomeprazole?

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Generic Name: Esomeprazole Brand Name(s): Generics only. No brands available.

Know the basics

What is esomeprazole used for?

Esomeprazole is commonly used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). Esomeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).

Esomeprazole works by decreasing the amount of acid your stomach makes. Esomeprazole relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. Esomeprazole helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus.

How should I take esomeprazole?

Take esomeprazole by mouth as directed by your doctor, usually once daily, at least 1 hour before a meal. Dosage and length of esomeprazole are based on your medical condition and response to treatment.

Do not crush or chew esomeprazole. Swallow the capsules whole. If you have difficulty swallowing esomeprazolewhole, you may open the capsule and sprinkle the contents into a tablespoon of unheated applesauce. Swallow the applesauce mixture right away without chewing it. Do not prepare the mixture ahead of time for later use. Doing so may destroy the drug.

If needed, antacids may be taken along with esomeprazole. If you are also taking sucralfate, take esomeprazole at least 30 minutes before sucralfate.

Use esomeprazole regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Continue to take esomeprazole for the prescribed length of treatment even if you are feeling better.

Tell your doctor if your condition persists or worsens.

How do I store esomeprazole?

Esomeprazole is best stored at room temperature away from direct light and moisture. To prevent esomeprazole damage, you should not store esomeprazole in the bathroom or the freezer. There may be different brands of esomeprazole that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush esomeprazole down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard esomeprazole when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using esomeprazole?

Before taking esomeprazole,

  • Tell your doctor and pharmacist if you are allergic to esomeprazole, dexlansoprazole (Dexilant), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), rabeprazole (aciphex), any other medications, or any of the ingredients in esomeprazole capsules or powder. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what other prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antibiotics, anticoagulants (‘blood thinners’); certain antifungals; cilostazol (Pletal); clopidogrel (Plavix); diazepam (Valium); digoxin (Digitek, Lanoxicaps, Lanoxin); diuretics (‘water pills’); iron supplements; certain medications for human immunodeficiency virus (HIV) and methotrexate (Rheumatrex, Trexall). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • Tell your doctor if you have or have ever had a low level of magnesium in your blood or liver disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking esomeprazole, call your doctor.
  • If you are 50 years of age or older, ask your doctor if it is safe for you to use esomeprazole. The risk that you may develop a severe form of diarrhea caused by bacteria or that you may fracture your wrist, hip, or spine may be higher if you are an older adult.
  • You may take antacids with esomeprazole. If you feel you need an antacid, ask your doctor to recommend one and to tell you when and how to take it.

Is it safe to take esomeprazole during pregnancy or breast-feeding?

There are no adequate studies in women for determining infant risk when using esomeprazole during breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking esomeprazole. Esomeprazoleis pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Know the side effects

What are the side effects of esomeprazole?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using esomeprazole and call your doctor at once if you have symptoms of low magnesium such as:

  • dizziness, confusion;
  • fast or uneven heart rate;
  • jerking muscle movements;
  • jittery feeling;
  • diarrhea that is watery or bloody;
  • muscle cramps, muscle weakness or limp feeling;
  • cough or choking feeling; or
  • seizure (convulsions).

Less serious side effects may include: headache, drowsiness; mild diarrhea; nausea, tomach pain, gas, constipation; or dry mouth.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with esomeprazole?

Esomeprazole may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Using esomeprazole with Rilpivirine is not recommended. Your doctor may decide not to treat you with esomeprazole or change some of the other medicines you take.

Using esomeprazole with any of the following medicines is usually not recommended, but may be required in some cases: Atazanavir, Bosutinib, Citalopram, Clopidogrel, Dabrafenib, Dasatinib, Erlotinib, Eslicarbazepine Acetate, Ketoconazole, Ledipasvir, Methotrexate, Mycophenolate Mofetil, Nelfinavir, Nilotinib, Pazopanib, Posaconazole, Saquinavir, Tacrolimus, Thiopental, Vismodegib.  If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using esomeprazole with Cranberry, Levothyroxine, Risedronate, Warfarin may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Does food or alcohol interact with esomeprazole?

Esomeprazole may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with esomeprazole?

Esomeprazole may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Diarrhea;
  • Hypomagnesemia (low magnesium in the blood), history of;
  • Osteoporosis (thinning of the bones);
  • Seizures, history of—Use with caution. May make these conditions worse;
  • Liver disease, severe—Use with caution. The effects may be increased because of slower removal of esomeprazole from the body.

Understand the dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using esomeprazole. 

What is the dose of Esomeprazole for an adult?

Usual Adult Dose for Gastroesophageal Reflux Disease (GERD):

  • Esomeprazole Magnesium: 20 mg orally once a day for 4 weeks;
  • Esomeprazole Strontium: 24.65 mg orally once a day for 4 to 8 weeks;
  • GERD with Erosive Esophagitis: Esomeprazole Sodium 20 mg or 40 mg intravenous injection once a day, over no less than 3 minutes; or intravenous infusion once a day, over no less than 10 to 30 minutes;

Usual Adult Dose for Erosive Esophagitis:

  • Healing:
  • esomeprazole Magnesium: 20 to 40 mg orally once a day for 4 to 8 weeks;
  • esomeprazole Strontium: 24.65 to 49.3 mg orally once a day for 4 to 8 weeks;
  • Maintenance of healing: An additional 4 to 8 week course of therapy may be considered in patients not healed after initial treatment.
  • esomeprazole Magnesium: 20 mg orally once a day;
  • esomeprazole Strontium: 24.65 mg orally once a daily;

Usual Adult Dose for Helicobacter pylori Infection:

  • Esomeprazole Magnesium: 40 mg orally once a day for 10 days, along with amoxicillin 1000 mg and clarithromycin 500 mg orally twice a day for 10 days;
  • Esomeprazole Strontium: 49.3 mg orally once a day for 10 days, along with amoxicillin 1000 mg and clarithromycin 500 mg orally twice a day for 10 days.

Usual Adult Dose for NSAID-Induced Gastric Ulcer:

  • Esomeprazole Magnesium: 20 mg to 40 mg orally once daily for up to 6 months;
  • Esomeprazole Strontium: 24.65 mg to 49.3 mg orally once a day for up to 6 months;

    Usual Adult Dose for Zollinger-Ellison Syndrome:

  • Esomeprazole Magnesium: 40 mg orally twice a day;
  • Esomeprazole Strontium: 49.3 mg orally twice a day;

    Usual Adult Dose for Pathological Hypersecretory Conditions:

  • Esomeprazole Magnesium: 40 mg orally twice a day;
  • Esomeprazole Strontium: 49.3 mg orally twice a day;

    Usual Adult Dose for Duodenal Ulcer Prophylaxis:

  • Esomeprazole Sodium:
  • initial dose: 80 mg intravenous infusion over 30 minutes;
  • maintenance dose: 8 mg/hr intravenous continuous infusion for a total of 72 hours (includes initial 30 minute dose plus 71.5 hours of continuous infusion);

Usual Adult Dose for Gastric Ulcer Prophylaxis

  • Initial dose: Esomeprazole Sodium 80 mg intravenous infusion over 30 minutes;
  • Maintenance dose: Esomeprazole Sodium 8 mg/hr intravenous continuous infusion for a total of 72 hours (includes initial 30 minute dose plus 71.5 hours of continuous infusion);

What is the dose of Esomeprazole for a child?

Usual Pediatric Dose for Gastroesophageal Reflux Disease

  • Esomeprazole Magnesium:
  • for patients less than 1 years: The dosage has not been established in pediatric patients less than 1 years. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.
  • for children from 1 to 11 years : 10 mg once a day for up to 8 weeks;
  • for children from 12 to 17 years: 20 mg once a day for 4 weeks;
  • Esomeprazole Sodium: for treatment of GERD with Erosive Esophagitis
    • for children Less than 1 month: using Esomeprazole is not recommended;
    • for children from 1 month to less than 1 year: -0.5 mg/kg intravenous infused over 10 to 30 minutes;
    • for children from 1 to 17 years and less than 55 kg: 10 mg intravenous infused over 10 to 30 minutes;
    • for children from 1 to 17 years and 55 kg or more: 20 mg intravenous infused over 10 to 30 minutes;
  • Esomeprazole Strontium: using Esomeprazole Strontium is not recommended for children.

Usual Pediatric Dose for Erosive Esophagitis

  • Healing: dosage of Esomeprazole Magnesium
  • For children less than 1 year: The dosage of Esomeprazole Magnesium has not been established in pediatric patients less than 1 years. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information. For children from 1 to 11 years : 10 mg once a day for up to 8 weeks.
  • For children from 1 to 11 years: for children less than 20 kg: 10 mg once a day for 8 weeks. For children more than 20 kg: 10 mg or 20 mg once a day for 8 weeks.
  • For children from 12 to 17 years: 20 or 40 mg once a day for 4 to 8 weeks.
  • Erosive Esophagitis due to acid-mediated GERD:
  • For children less than 1 month: The dosage has not been established in pediatric patients less than 1 month. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.
  • For children from 1 month to less than 1 year old: for children 3 kg to 5 kg: 2.5 mg once a day. For children greater than 5 kg to 7.5 kg: 5 mg once a day. For children greater than 7.5 kg to 12 kg: 10 mg once a day. Duration of therapy: up to 6 weeks.
  • For children from 1 year and older: The dosage has not been established in pediatric patients from 1 year and older. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is esomeprazole available?

Esomeprazole is available in the following dosage forms and strengths:

  • Granules, for oral suspension, delayed release, as magnesium: 10 mg/packet
  • Tablet, extended release, as magnesium: 20 mg, 40 mg
  • Powder for solution for injection/infusion

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

Symptoms of overdose may include the following: confusion, drowsiness, blurred vision, fast heartbeat, nausea, sweating, flushing, headache, dry mouth

What should I do if I miss a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you miss a dose of esomeprazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: May 30, 2016 | Last Modified: January 4, 2017

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