Eslicarbazepine

By Medically reviewed by hellodoktor

Generic Name: Eslicarbazepine Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Eslicarbazepine used for?

Eslicarbazepine is used alone or with other medications to treat a certain type of seizure disorder (focal seizures). It belongs to a class of drugs known as anticonvulsants. Eslicarbazepine may reduce the number of seizures you have.

How should I take Eslicarbazepine?

Take this medication by mouth with or without food as directed by your doctor, usually once daily. The dosage is based on your medical condition and response to treatment. Children’s dosage is also based on weight.

To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Do not stop taking this medication without consulting your doctor. Some conditions (such as seizures) may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

Tell your doctor if your seizures worsen.

How do I store Eslicarbazepine?

Eslicarbazepine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Eslicarbazepine in the bathroom or the freezer. There may be different brands of Eslicarbazepine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Eslicarbazepine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Eslicarbazepine?

Before taking eslicarbazepine, tell your doctor or pharmacist if you are allergic to it; or to oxcarbazepine; or to carbamazepine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, mineral imbalance (such as low levels of sodium in the blood).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness or loss of coordination.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. However, since untreated seizures are a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy. Since hormonal birth control may not work if taken with this medication (see also Drug Interactions section), discuss reliable forms of birth control with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Eslicarbazepine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Eslicarbazepine. Eslicarbazepine is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Eslicarbazepine?

Headache, shaking, drowsiness, tiredness, dizziness, unsteadiness, feeling of spinning, nausea, or vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: rapid/uncontrollable eye movements, blurred/double vision, loss of balance/coordination, signs of infection (such as sore throat that doesn’t go away, fever, chills), easy bruising/bleeding, pale skin.

A small number of people who take anticonvulsants for any condition (such as seizure, bipolar disorder, pain) may experience depression, suicidal thoughts/attempts, or other mental/mood problems. Tell your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior including signs of depression, suicidal thoughts/attempts, thoughts about harming yourself.

Get medical help right away if you have any very serious side effects, including: signs of liver disease (such as dark urine, persistent nausea, vomiting, stomach/abdominal pain, yellowing eyes/skin), signs of low level of sodium in the blood (such as severe nausea, extreme drowsiness, confusion, irritability, new or worsening seizures), muscle weakness/tenderness/pain.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Eslicarbazepine?

Some products that may interact with this drug include: orlistat, rilpivirine.

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for at least 1 menstrual cycle after the end of treatment. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), and narcotic pain relievers (such as codeine, hydrocodone).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Eslicarbazepine is very similar to oxcarbazepine. Do not use medications containing oxcarbazepine while using eslicarbazepine.

This medication may interfere with certain laboratory tests (including thyroid tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Eslicarbazepine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Eslicarbazepine?

Eslicarbazepine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Eslicarbazepine?

Eslicarbazepine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Eslicarbazepine.

What is the dose of Eslicarbazepine for an adult?

Usual Adult Dose for Epilepsy

Monotherapy and Adjunctive Therapy:

-Initial dose: 400 mg orally once a day; some patients may be initiated at 800 mg orally once a day if the need for seizure reduction outweighs an increased risk of adverse reactions

-Dose titration: Increase dosage by 400 to 600 mg weekly, based on response and tolerability

-Maintenance dose: 800 to 1600 mg orally once a day; for patients on monotherapy, the 800 mg once daily maintenance dose should be considered in patients who are unable to tolerate a 1200 mg daily dose; for patients on adjunctive therapy, the 1600 mg daily dose should be considered in patients who did not achieve a satisfactory response with a 1200 mg daily dose

Usual Adult Dose for Seizures

Monotherapy and Adjunctive Therapy:

-Initial dose: 400 mg orally once a day; some patients may be initiated at 800 mg orally once a day if the need for seizure reduction outweighs an increased risk of adverse reactions

-Dose titration: Increase dosage by 400 to 600 mg weekly, based on response and tolerability

-Maintenance dose: 800 to 1600 mg orally once a day; for patients on monotherapy, the 800 mg once daily maintenance dose should be considered in patients who are unable to tolerate a 1200 mg daily dose; for patients on adjunctive therapy, the 1600 mg daily dose should be considered in patients who did not achieve a satisfactory response with a 1200 mg daily dose

Renal Dose Adjustments

-CrCl 50 mL/min or greater: No adjustment recommended.

-CrCl less than 50 mL/min: The initial, titration, and maintenance dosages should generally be reduced by 50%; titration and maintenance dosages may be adjusted per clinical response.

Liver Dose Adjustments

-Mild to moderate liver impairment: No adjustment recommended.

Dose Adjustments

-The dosage should be reduced gradually to minimize the risk of increased seizure frequency and status epilepticus.

-Carbamazepine reduces the plasma concentration of this drug; when taken concomitantly, the dose of one of the drugs may need to be adjusted based on efficacy and tolerability.

-For patients taking other enzyme-inducing antiepileptic drugs (AEDs) (i.e., phenobarbital, phenytoin, primidone), higher doses of this drug may be needed.

-This drug should not be taken as an adjunctive therapy with oxcarbazepine.

Dialysis

Hemodialysis partially removes this drug.

What is the dose of Eslicarbazepine for a child?

Usual Pediatric Dose for Epilepsy

4 to less than 18 years:

Monotherapy and Adjunctive Therapy:

11 to 21 kg:

-Initial dose: 200 mg orally once a day; increase once a week in increments of no more than 200 mg, based on tolerability and response

-Maintenance dose: 400 to 600 mg orally once a day

-Maximum dose: 600 mg orally once a day

22 to 31 kg:

-Initial dose: 300 mg orally once a day; increase once a week in increments of no more than 300 mg, based on tolerability and response

-Maintenance dose: 500 to 800 mg orally once a day

-Maximum dose: 800 mg orally once a day

32 to 38 kg:

-Initial dose: 300 mg orally once a day; increase once a week in increments of no more than 300 mg, based on tolerability and response

-Maintenance dose: 600 to 900 mg orally once a day

-Maximum dose: 900 mg orally once a day

Greater than 38 kg:

-Initial dose: 400 mg orally once a day; increase once a week in increments of no more than 400 mg, based on tolerability and response

-Maintenance dose: 800 to 1200 mg orally once a day

-Maximum dose: 1200 mg orally once a day

Usual Pediatric Dose for Seizures

4 to less than 18 years:

Monotherapy and Adjunctive Therapy:

11 to 21 kg:

-Initial dose: 200 mg orally once a day; increase once a week in increments of no more than 200 mg, based on tolerability and response

-Maintenance dose: 400 to 600 mg orally once a day

-Maximum dose: 600 mg orally once a day

22 to 31 kg:

-Initial dose: 300 mg orally once a day; increase once a week in increments of no more than 300 mg, based on tolerability and response

-Maintenance dose: 500 to 800 mg orally once a day

-Maximum dose: 800 mg orally once a day

32 to 38 kg:

-Initial dose: 300 mg orally once a day; increase once a week in increments of no more than 300 mg, based on tolerability and response

-Maintenance dose: 600 to 900 mg orally once a day

-Maximum dose: 900 mg orally once a day

Greater than 38 kg:

-Initial dose: 400 mg orally once a day; increase once a week in increments of no more than 400 mg, based on tolerability and response

-Maintenance dose: 800 to 1200 mg orally once a day

-Maximum dose: 1200 mg orally once a day

Precautions

Safety and efficacy have not been established in patients younger than 4 years.

How is Eslicarbazepine available?

Eslicarbazepine is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Eslicarbazepine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 20, 2018 | Last Modified: September 12, 2019

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