Ergometrine

By Medically reviewed by hellodoktor

Generic Name: Ergometrine Brand Name(s): Generics only. No brands available.

Uses

What is ergometrine used for?

Ergometrine is commonly used for preventing and treating bleeding after delivery of a baby or an abortion. It may also be used for other conditions as determined by your doctor.

Ergometrine is a uterine stimulant. It works by increasing uterine contractions, which helps reduce blood loss after the baby is delivered.

How should I take ergometrine?

Use ergometrine as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

Ergometrine may be taken with or without food.

Do not use ergometrine for more than 1 week unless instructed by your doctor.

Ask your health care provider any questions you may have about how to use ergometrine.

How do I store ergometrine?

Ergometrine is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of ergometrine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush ergometrine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Stability:
Ergometrine maleate ampules may be stored at room temperature for up to 60 days.  At any time, discolored solutions or solutions containing visible particles should not be used.

Precautions & warnings

What should I know before using ergometrine?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in
  • You are planning to become pregnant or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.

Important safety information:

  • Do not exceed the recommended dose or take ergometrine for longer than prescribed without checking with your doctor.
  • Lab tests, including blood pressure, pulse, and uterine response, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use ergometrine with extreme caution in children. Safety and effectiveness have not been confirmed.

Is it safe during pregnancy or breastfeeding?

Pregnancy

Do not use ergometrine if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately.

Breastfeeding:

Ergometrine is excreted in breast milk. If you are or will be breastfeeding while you are using ergometrine, check with your doctor or pharmacist to discuss the risks to your baby.

Side effects

What side effects can occur from ergometrine?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Cramping of the uterus

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Blood in the urine
  • Chest pain or tightness
  • Diarrhea
  • Dizziness
  • Hallucinations
  • Headache
  • Irregular heartbeat
  • Leg cramps
  • Mental or mood changes
  • Numbness or tingling of the hands, feet, or skin
  • Ringing in the ears
  • Seizure
  • Severe or persistent nausea or vomiting
  • Shortness of breath

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with ergometrine?

Ergometrine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Productc may interact with this drug, including:

  • Azole antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • Clotrimazole
  • Ergot alkaloids (e.g., ergotamine)
  • Fluconazole
  • Fluoxetine
  • Fluvoxamine
  • Nefazodone
  • Saquinavir
  • Zileuton
  • HIV protease inhibitors (e.g., delavirdine, indinavir, nelfinavir, ritonavir)
  • Efavirenz
  • Ketolide antibiotics (e.g., telithromycin)
  • Macrolide antibiotics (e.g., erythromycin, clarithromycin)
  • Selective 5-HT agonists (e.g., sumatriptan, eletriptan)

Does food or alcohol interact with ergometrine?

Ergometrine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Eating grapefruit or drinking grapefruit juice may affect the amount of ergometrine in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.

What health conditions may interact with ergometrine?

Ergometrine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Tell your doctor if you have:

  • A blood infection or a history of blood vessel problems
  • Blood problems (e.g., porphyria)
  • High blood pressure
  • Stroke
  • Liver problems
  • Kidney problems
  • Low blood calcium levels
  • Heart problems
  • Eclampsia or preeclampsia

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using ergometrine.

What is the dose of ergometrine for an adult?

The recommeded dose is 0.2 mg IM; may repeat in 2-4hr; not to exceed 5 doses total. Give IV only in emergency because of potential for HTN & CVA.

Alternatively, the dose is 0.2-0.4 mg PO q6-12hr PRN for 48 hr or until danger of uterine atony has passed; no more than 1 week.

Give over >1 minute & monitor BP.

What is the dose of ergometrine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is ergometrine available?

Ergometrine is available in the following dosage forms and strengths:

  • Ergometrine injection BP 0.05% w/v
  • 500 micrograms of ergometrine in 1ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of ergometrine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: February 10, 2017 | Last Modified: September 12, 2019

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