Engerix B


Generic Name: Engerix B Brand Name(s): Generics only. No brands available.


What is Engerix-B® (hepatitis B adult vaccine) used for?

Engerix-B® is a vaccine indicated for immunization against infection caused by all known subtypes of hepatitis B virus.

It may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Engerix-B® (hepatitis B adult vaccine)?

Engerix-B® is given as an injection (shot) into a muscle. You will receive this injection in a doctor’s office or other clinic setting.

The Engerix-B® is given in a series of shots. The booster shots are sometimes given 1 month and 6 months after the first shot. If you have a high risk of hepatitis B infection, you may be given an additional booster 1 to 2 months after the third shot.

Your individual booster schedule may be different from these guidelines. Follow your doctor’s instructions or the schedule recommended by your local health department.

How do I store Engerix-B® (hepatitis B adult vaccine)?

Engerix-B® is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Engerix-B® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Engerix-B® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Engerix-B® (hepatitis B adult vaccine)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Engerix-B® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Is it safe during pregnancy or breastfeeding?


There are no adequate studies in women for determining risk when using Engerix-B® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Engerix-B®. Engerix-B® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Not known if excreted in breast milk.

Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding.

Side effects

What side effects can occur from Engerix-B® (hepatitis B adult vaccine)?

Here are side effects:

  • Pain
  • Redness
  • Swelling
  • Fatigue
  • Gastro-enteritis
  • Headache
  • Fever

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Engerix-B® (hepatitis B adult vaccine)?

Engerix-B® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with Engerix-B® including:

  • Immunosuppressive therapy (e.g., some medications used for the treatment of cancer or for transplant recipients)

Does food or alcohol interact with Engerix-B® (hepatitis B adult vaccine)?

Engerix-B® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Engerix-B® (hepatitis B adult vaccine)?

Engerix-B® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions may interact when using with Engerix-B®:

  • Multiple sclerosis
  • Kidney disease (or if you are on dialysis)
  • A bleeding or blood clotting disorder (such as hemophilia or easy bruising)
  • An allergy to latex rubber
  • A neurologic disorder or disease affecting the brain (or if this was a reaction to a previous vaccine)
  • Current illness with fever


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Engerix-B® (hepatitis B adult vaccine) for an adult?

For intramuscular administration

Persons 20 years of age and older, a series of 3 doses (1 ml each) on a 0-1-6month schedule.


A series of 4 doses (2 ml each) as a single 2-ml dose or as two 1-ml doses on a 0-1-2-6-month schedule.

What is the dose of Engerix-B® (hepatitis B adult vaccine) for a child?

For intramuscular administration

Persons from birth through 19 years of age, a series of 3 doses (0.5 ml each) on a 0-1-6-month schedule.

How is Engerix-B® (hepatitis B adult vaccine) available?

Engerix-B is a sterile suspension available in the following presentations:

  • 5-ml (10 mcg) single-dose vials and prefilled syringes
  • 1-ml (20 mcg) single-dose vials and prefilled syringes

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

It is also important to carry a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking with you in case of emergencies.

What should I do if I miss a dose?

If you miss a dose of Engerix-B®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: December 29, 2016 | Last Modified: January 4, 2017

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