Generic Name: Eloxatin Brand Name(s): Generics only. No brands available.

Uses

What is Eloxatin® (oxaliplatin) used for?

Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It works by killing cancer cells.

Eloxatin® is used with other medications to treat advanced colon or rectal cancer (cancer that begins in the large intestine) and prevent colon cancer from spreading in people who have had surgery to remove the tumor.

How should I take Eloxatin® (oxaliplatin)?

Oxaliplatin comes as a solution (liquid) to be injected into a vein. Oxaliplatin is administered by a doctor or nurse. It is usually given once every fourteen days.

How do I store Eloxatin® (oxaliplatin)?

Eloxatin® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Eloxatin® in the bathroom or the freezer. There may be different brands of Eloxatin® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Eloxatin® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Eloxatin® (oxaliplatin)?

Before using this drug, you should know that:

  • Oxaliplatin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Oxaliplatin may lower the ability of your body to fight infection. Avoid contact with people who have colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first.
  • Do not receive a live vaccine (e.g., measles, mumps) while you are taking oxaliplatin. Talk with your doctor before you receive any vaccine.
  • Some patients using oxaliplatin have developed severe and sometimes fatal lung problems. Tell your doctor right away if you develop a dry cough, or trouble breathing or shortness of breath.
  • You can reduce sensitivity to cold temperatures or objects by doing the following: cover yourself with a blanket while receiving oxaliplatin; do not breathe deeply when exposed to cold air; wear warm clothing in cold weather at all times; cover your mouth and nose with a scarf or a ski cap to warm the air that goes into your lungs; wear gloves when removing items from the freezer and refrigerator or when touching car doors, mailboxes, or other metal objects; drink fluids warm or at room temperature; drink beverages with a straw; do not use ice chips if you have nausea or mouth sores; do not put ice packs on your body; do not run the air conditioning at high levels in the house or car during hot weather; if you get cold, warm up only the cold part of your body; warm cold hands up with warm water.
  • Oxaliplatin may rarely cause a serious brain problem called reversible posterior leukoencephalopathy syndrome (RPLS). Contact your doctor right away if you experience severe headache, seizures, confusion, problems thinking, or vision changes (e.g., blurred vision, loss of vision).
  • Tell your doctor or dentist that you take oxaliplatin before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including complete blood cell counts, kidney function, and liver function, may be performed while you use oxaliplatin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use oxaliplatin with caution in the elderly; they may be more sensitive to its effects, especially diarrhea, dehydration, low potassium levels, fatigue, fainting, and increased risk of infection.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Eloxatin® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Eloxatin®. Eloxatin® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Eloxatin® (oxaliplatin)?

When using Eloxatin®, it can occur some side effects, such as:

  • Numbness, burning, or tingling in the fingers, toes, hands, feet, mouth, or throat
  • Increased sensitivity, especially to cold
  • Decreased sense of touch
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Stomach pain
  • Heartburn
  • Sores in the mouth
  • Loss of appetite
  • Change in the ability to taste food
  • Weight gain or loss
  • Hiccups
  • Dry mouth
  • Muscle, back, or joint pain
  • Tiredness
  • Anxiety
  • Depression
  • Difficulty falling asleep or staying asleep
  • Hair loss
  • Dry skin
  • Redness or peeling of the skin on the hands and feet
  • Sweating
  • Flushing

Some side effects can be serious. If you experience any of these symptoms or those listed in the important warning section, call your doctor immediately:

  • Stumbling or loss of balance when walking
  • Difficulty with everyday activities such as writing or fastening buttons
  • Difficulty speaking
  • Strange feeling in the tongue
  • Tightening of the jaw
  • Chest pain or pressure
  • Cough
  • Shortness of breath
  • Sore throat, fever, chills, and other signs of infection
  • Pain, redness, or swelling in the place where oxaliplatin was injected
  • Pain when urinating
  • Decreased urination
  • Unusual bruising or bleeding
  • Nosebleed
  • Blood in urine
  • Vomit that is bloody or looks like coffee grounds
  • Bright red blood in stool or black and tarry stools
  • Pale skin
  • Weakness
  • Problems with vision
  • Swelling of the arms, hands, feet, ankles, or lower legs

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Eloxatin® (oxaliplatin)?

Eloxatin® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some products may interact with this medicine include:

  • Minoglycosides (e.g., gentamicin, amikacin)
  • Amphotericin B
  • Nalidixic acid
  • Nonsteroidal anti-inflammatory drugs (such as ibuprofen)
  • Tacrolimus

Does food or alcohol interact with Eloxatin® (oxaliplatin)?

Eloxatin® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Eloxatin® (oxaliplatin)?

Eloxatin® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Diabetes

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Eloxatin® (oxaliplatin).

What is the dose of Eloxatin® (oxaliplatin) for an adult?

Colorectal cancer:

Day 1:
Eloxatin® 85 mg/m2 and leucovorin 200 mg/m2 intravenously over 120 minutes, followed by fluorouracil 400 mg/m2 over 2 to 4 minutes, followed by fluorouracil 600 mg/m2 as a 22 hour infusion.

Day 2:
Leucovorin 200 mg/m2 intravenously over 120 minutes, followed by fluorouracil 400 mg/m2 over 2 to 4 minutes, followed by fluorouracil 600 mg/m2 as a 22 hour infusion.
The cycle is repeated every 2 weeks.

What is the dose of Eloxatin® (oxaliplatin) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Eloxatin® (oxaliplatin) available?

Eloxatin® is available in the following dosage forms and strengths:

  • Injection 10ml
  • Solution 10ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Eloxatin®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: February 6, 2017 | Last Modified: February 6, 2017

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