Eliquis

By Medically reviewed by hellodoktor

Generic Name: Eliquis Brand Name(s): Generics only. No brands available.

Uses

What is Eliquis® (apixaban) used for?

Eliquis® blocks the activity of certain clotting substances in the blood.

Eliquis® is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation.

Eliquis® is also used after hip or knee replacement surgery to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism).

Eliquis® is also used to treat DVT or pulmonary embolism (PE), and to lower your risk of having a repeat DVT or PE.

How should I take Eliquis® (apixaban)?

Eliquis® is usually taken twice per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Eliquis® with or without food.

To make swallowing easier, you may crush an Eliquis® tablet and mix the medicine with water or apple juice, or with a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use. The mixture will no longer be good after 4 hours.

Eliquis® can be given through a nasogastric (NG) feeding tube. Crush the tablet and mix the medicine in a syringe with 60 milliliters of 5% dextrose in water (D5W). Give this mixture right away through the NG tube. Do not save for later use. Do not give this mixture by mouth.

Because Eliquis® keeps your blood from coagulating (clotting) to prevent unwanted blood clots, this medicine can also make it easier for you to bleed, even from a minor injury such as a fall or a bump on the head. Contact your doctor or seek emergency medical attention if you fall or hit your head, or have any bleeding that will not stop.

If you need surgery or dental work, tell the doctor or dentist ahead of time if you have taken Eliquis® within the past 24 hours. You may need to stop taking this medicine for a short time before you have surgery or other medical procedures.

Do not stop taking Eliquis® unless your doctor tells you to. Stopping suddenly can increase your risk of blood clot or stroke.

If you stop taking this medicine for any reason, your doctor may prescribe another medication to prevent blood clots until you start taking Eliquis® again.

Use regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

How do I store Eliquis® (apixaban)?

Eliquis® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Eliquis® in the bathroom or the freezer. There may be different brands of Eliquis® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Eliquis® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Eliquis® (apixaban)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Eliquis® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not take Eliquis® if you have an artificial heart valve, or if you have any active bleeding from a surgery, injury, or other cause.

Eliquis® may cause you to bleed more easily, especially if you have a bleeding disorder that is inherited or caused by disease.

Eliquis® can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause long-term paralysis, and may be more likely to occur if:

  • You have a spinal catheter in place or if a catheter has been recently removed.
  • You have a history of spinal surgery or repeated spinal taps.
  • You have recently had a spinal tap or epidural anesthesia.
  • You are taking an NSAID (nonsteroidal anti-inflammatory drug) – ibuprofen (Advil, Motrin), naproxen (Aleve), diclofenac, indomethacin, meloxicam, and others.
  • You are using other medicines to treat or prevent blood clots.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Eliquis® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Eliquis®. Eliquis® is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Eliquis® (apixaban)?

Call your doctor at once if you have:

  • Easy bruising
  • Unusual bleeding (nose, mouth, vagina, or rectum)
  • Bleeding from wounds or needle injections
  • Any bleeding that will not stop
  • Heavy menstrual periods
  • Headache, dizziness, weakness, feeling like you might pass out
  • Urine that looks red, pink, or brown
  • Black or bloody stools
  • Coughing up blood or vomit that looks like coffee grounds

Also seek emergency medical attention if you have symptoms of a spinal blood clot: back pain, numbness or muscle weakness in your lower body, or loss of bladder or bowel control.

Get emergency medical help if you have signs of an allergic reaction to Eliquis: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Eliquis® (apixaban)?

Eliquis® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • John’s wort
  • An antibiotic – clarithromycin, rifampin, telithromycin
  • Antifungal medicine – itraconazole, ketoconazole, posaconazole, voriconazole
  • The hepatitis C medications boceprevir or telaprevir
  • HIV or AIDS medication – atazanavir, cobicistat (Evotaz, Stribild, Prezcobix, Tybost), fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir
  • Seizure medicine – carbamazepine, fosphenytoin, phenobarbital, phenytoin
  • Dabigatran, dalteparin, enoxaparin, fondaparinux, heparin, tinzaparin, warfarin, Coumadin, Jantoven
  • An antidepressant such as citalopram, duloxetine, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, venlafaxine, vilazodone
  • An NSAID such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others
  • Salicylates such as aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others

Does food or alcohol interact with Eliquis® (apixaban)?

Eliquis® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Eliquis® (apixaban)?

Eliquis® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Kidney disease (or if you are on dialysis)
  • Liver disease

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Eliquis® (apixaban).

What is the dose of Eliquis® (apixaban) for an adult?

Usual Adult Dose for Deep Vein Thrombosis – Prophylaxis:

The recommended dose is 2.5 mg orally 2 times a day.

Duration of therapy:

  • Hip replacement: 35 days
  • Knee replacement: 12 days

Usual Adult Dose for Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery:

The recommended dose is 2.5 mg orally 2 times a day.

Duration of therapy:

  • Hip replacement: 35 days
  • Knee replacement: 12 days

Usual Adult Dose for Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery:

The recommended dose is 2.5 mg orally 2 times a day

Duration of therapy:

  • Hip replacement: 35 days
  • Knee replacement: 12 days

Usual Adult Dose for Prevention of Thromboembolism in Atrial Fibrillation:

The recommended dose is 5 mg orally 2 times a day.

Usual Adult Dose of Eliquis for Thromboembolic Stroke Prophylaxis:

The recommended dose is 5 mg orally 2 times a day.

Usual Adult Dose for Deep Vein Thrombosis:

Initial dose: 10 mg orally 2 times a day for 7 days.

Maintenance dose: 5 mg orally 2 times a day.

Usual Adult Dose for Pulmonary Embolism:

Initial dose: 10 mg orally 2 times a day for 7 days.

Maintenance dose: 5 mg orally 2 times a day.

What is the dose of Eliquis® (apixaban) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Eliquis® (apixaban) available?

Eliquis® is available in the following dosage forms and strengths:

  • Tablet, film coated apixaban 2.5mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Eliquis®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: July 14, 2017 | Last Modified: September 13, 2019

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