By Medically reviewed by hellodoktor

Generic Name: Ecazide Brand Name(s): Ecazide.


What is ecazide used for?

Ecazide is the combination of captopril and hydrochlorothiazide. It is commonly used for treating high blood pressure (hypertension).

It may be for other conditions, ask your doctor for more information.

How should I take ecazide?

Use ecazide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take ecazide by mouth on an empty stomach 1 hour before meals.

Ecazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

Ecazide works best if it is taken at the same time each day.

Continue to take ecazide even if you feel well. Do not miss any doses.

Ask your health care provider any questions you may have about how to use ecazide.

How do I store ecazide?

Ecazide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store ecazide in the bathroom or the freezer. There may be different brands of ecazide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush ecazide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using ecazide?

Before using ecazide, tell your doctor if:

  • You are allergic to any ingredient in ecazide, any other sulfonamide medicine (e.g., sulfamethoxazole), or any other ACE inhibitor (e.g., enalapril).
  • You have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness) caused by an ACE inhibitor.
  • You are pregnant.
  • You are unable to urinate.
  • You are on dialysis, are receiving apheresis treatments, or are scheduled to have surgery or receive anesthesia.
  • You are receiving treatments to reduce sensitivity to bee or wasp stings.
  • You have recently had a certain type of nerve surgery (sympathectomy).

Besides, there is some important information that you may notice:

  • Ecazide may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use ecazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Ecazide may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Report any light-headedness or fainting to your doctor immediately. Your risk of light-headedness or fainting may be increased if you experience diarrhea, vomiting, or excessive sweating; if you do not drink enough fluids; or if you are on a low-salt (sodium) diet.
  • It may take up to 6 to 8 weeks to get the full benefit from ecazide. Do not stop using ecazide or change your dose without checking with your doctor.
  • Tell your doctor or dentist that you take ecazide before you receive any medical or dental care, emergency care, or surgery.
  • Ecazide contains a sulfonamide called hydrochlorothiazide, which can cause certain eye problems (myopia, angle-closure glaucoma). Your risk may be increased if you are allergic to sulfonamide medicines (e.g., sulfamethoxazole) or to penicillin antibiotics (e.g., amoxicillin). Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting captopril/hydrochlorothiazide. Contact your doctor right away if you experience symptoms such as vision changes (e.g., decreased vision clearness) or eye pain.
  • Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not take additional potassium or change your diet to include more potassium without first checking with your doctor.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Ecazide may cause a dry, unproductive cough. If caused by ecazide, this symptom usually stops after treatment with ecazide is stopped.
  • Ecazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to ecazide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel normal. Tell your doctor if you develop any new symptoms.
  • Ecazide may cause a serious side effect called angioedema. The risk may be higher in black patients. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
  • Ecazide may lower the ability of your body to fight infection. The risk may be greater if you have certain other health problems (e.g., kidney problems, collagen vascular disease). Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Ecazide may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Diabetes patients: ecazide may cause the results of some tests for urine ketones to be wrong. Be sure to check blood sugar levels closely. Ask your doctor before you change your diet or the dose of your diabetes medicine.
  • Ecazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Ecazide may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking ecazide.
  • Lab tests, including blood pressure monitoring, blood potassium or other electrolyte levels, kidney function, and urine protein, may be performed while you use captopril/hydrochlorothiazide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Ecazide should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using ecazide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking ecazide. Ecazide is pregnancy risk category C (1st trimester) and D (2nd and 3rd trimester), according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from ecazide?

Check with your doctor if any of these most common side effects persist or become bothersome:

  • Cough
  • Dizziness or light-headedness when sitting or standing quickly
  • Taste changes

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness)
  • Burning, numbness, or tingling
  • Chest pain
  • Confusion
  • Decrease in amount of urine produced
  • Depression
  • Drowsiness
  • Eye pain
  • Fainting
  • Fever, chills, or persistent sore throat
  • Joint pain
  • Muscle pain, cramps, or tremors
  • Numbness of an arm or leg
  • One-sided weakness
  • Red, swollen, blistered, or peeling skin
  • Restlessness
  • Seizures
  • Severe or persistent dizziness or light-headedness
  • Severe or persistent nausea or vomiting
  • Shortness of breath
  • Slow, fast, or irregular heartbeat
  • Slurred speech
  • Stomach pain (with or without nausea and vomiting)
  • Sudden, severe headache or vomiting
  • Swelling of the arms or legs
  • Symptoms of liver problems (e.g., dark urine, loss of appetite, pale stools, yellowing of the skin or eyes)
  • Unusual bruising or bleeding
  • Unusually dry mouth
  • Unusual thirst
  • Unusual tiredness or weakness
  • Vision problems (e.g., blurred vision, decreased vision clearness)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with ecazide?

Ecazide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Digoxin, dofetilide, or ketanserin, because the risk of irregular heartbeat may be increased.
  • Eplerenone, potassium preparations, potassium-sparing diuretics (e.g., triamterene), salt substitutes containing potassium, or trimethoprim, because the risk of high blood potassium levels may be increased.
  • Everolimus or sirolimus, because the risk of angioedema may be increased.
  • Aliskiren or angiotensin receptor blockers (ARBs) (e.g., losartan), because the risk of certain side effects (e.g., kidney problems, high blood potassium levels, low blood pressure) may be increased.
  • Certain gold-containing medicines (e.g., sodium aurothiomalate), because flushing, nausea, vomiting, and low blood pressure may occur.
  • Adrenocorticotropic hormone (ACTH), amphotericin B, barbiturates (e.g., phenobarbital), beta-blockers (e.g., propranolol), calcium supplements, corticosteroids (e.g., prednisone), dextran sulfate, diazoxide, diuretics (e.g., furosemide), monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine), narcotic pain medicines (e.g., codeine, fentanyl, morphine), nitrates (e.g., nitroglycerin), or other medicines for high blood pressure, because they may increase the risk of side effects.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., celecoxib, ibuprofen, indomethacin), because they may decrease ecazide ‘s effectiveness and the risk of kidney problems may be increased.
  • Cholestyramine, colestipol, or salicylates (e.g., aspirin), because they may decrease ecazide’s effectiveness.
  • Lithium or thiopurines (e.g., azathioprine), because the risk of their side effects may be increased.
  • Anticoagulants (e.g., warfarin), insulin or other diabetes medicines (e.g., glyburide), methenamine, probenecid, or sulfinpyrazone because their effectiveness may be decreased.

Does food or alcohol interact with ecazide?

Ecazide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with ecazide?

Ecazide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially, if you have:

  • A history of angioedema
  • Bone marrow problems
  • Blood vessel problems of the heart or brain
  • Kidney disease (e.g., renal artery stenosis)
  • Kidney transplant
  • Heart problems (e.g., heart failure)
  • Liver problems
  • Diabetes
  • Parathyroid problems
  • A history of blood electrolyte problems (e.g., calcium, chloride, magnesium)
  • An autoimmune disease (e.g., rheumatoid arthritis, lupus, scleroderma)
  • Gout
  • Asthma
  • High blood cholesterol or lipid levels
  • Dehydrated
  • High blood potassium levels
  • Low blood volume
  • Low blood sodium levels
  • On a low-salt (sodium) diet


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using ecazide

What is the dose of ecazide for an adult?


Initial dose is 25 mg captopril/15 mg hydrochlorothiazide PO qDay; not to exceed 150 mg captopril/50 mg chlorothiazide.

Increase either or both components based on clinical response q6weeks.

To minimize dose-independent side effects, it is usually appropriate to begin combination therapy only after a patient has failed to achieve the desired effect with monotherapy.

Renal Impairment

CrCl ≥30mL/min: No dosage adjustment required

CrCl <30mL/min: Not recommended

What is the dose of ecazide for a child?

The dosage has not been established in child under 18 years old. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is ecazide available?

Ecazide is available in the following dosage forms and strengths:

  • Ecazide tablet: Captopril 50 mg, hydrochlorothiazide 25 mg.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room

What should I do if I miss a dose?

If you miss a dose of ecazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: April 5, 2017 | Last Modified: September 13, 2019

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.
You might also like