Generic Name: Domperidone Brand Name(s): Generics only. No brands available.

Know the basics

What is domperidone used for?

Domperidone is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson’s Disease.

How should I take domperidone?

Always take these tablets exactly as your doctor has told you.

You should check with your doctor or pharmacist if you are not sure.

Taking domperidone

Swallow the tablets whole with a drink of water.

Take the tablets 15 to 30 minutes before a meal and, if needed, before you go to bed.

Do not crush or chew them.

How do I store domperidone?

Domperidone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store domperidone in the bathroom or the freezer. There may be different brands of domperidone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush domperidone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using domperidone?

Tell your doctor if you:

  • are allergic (hypersensitive) to domperidone or any of the other ingredients of domperidone.
  • signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.
  • have a tumour of the pituitary gland (prolactinoma).
  • have black, tarry bowel motions (stools) or notice blood in your bowel motions. This could be a sign of bleeding from the stomach or intestines.
  • have a blockage or tear in your intestines.
  • have or have had liver problems.

Is it safe to take domperidone during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using domperidone during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking domperidone. Domperidone is pregnancy risk category  C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown.

Know the side effects

What are the side effects of domperidone?

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them.

Less common side effects include: Breast milk flowing from the nipple, dry mouth, swelling of the breast in the male, headache, hives, hot flashes, itching of skin, itching, redness, pain, or swelling of eye, menstrual irregularities, pain in the breast.

Rare side effects include: Change in need to urinate, change in appetite, constipation, diarrhea, burning, difficult, or painful urination, difficulty in speaking, dizziness, drowsiness, heartburn, irritability, lack or loss of strength, leg cramps, mental dullness, nervousness, palpitations, sluggishness, stomach cramps, thirst, tiredness, weakness.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with domperidone?

Domperidone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval, especially: Amifampridine, Bepridil, Cisapride, Darunavir, Dronedarone, Fluconazole, Ketoconazole, Mesoridazine, Pimozide, Piperaquine, Posaconazole, Saquinavir, Sparfloxacin, Thioridazine, Ziprasidone.

Using domperidone with any of the following medicines is usually not recommended, but may be required in some cases: Abiraterone Acetate, Alfuzosin, Alprazolam, Amiodarone, Amitriptyline, Amlodipine, Amoxapine, Amprenavir, Anagrelide, Apomorphine, Aprepitant, Aripiprazole, Arsenic Trioxide, Artemether, Asenapine, Astemizole, Atazanavir, Atorvastatin, Azithromycin, Bedaquiline, Bicalutamide, Boceprevir, Buserelin, Ceritinib, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clomipramine, Clozapine, Cobicistat, Conivaptan, Crizotinib, Cyclobenzaprine, Cyclosporine, Dabrafenib, Dasatinib, Delamanid, Delavirdine, Desipramine, Deslorelin, Diltiazem, Disopyramide, Dofetilide, Dolasetron, Doxepin, Droperidol, Ebastine, Eribulin, Erythromycin, Escitalopram, Famotidine, Felbamate, Fingolimod, Flecainide, Fluoxetine, Fluvoxamine, Formoterol, Fosamprenavir, Fosaprepitant, Foscarnet, Fosphenytoin, Galantamine, Gatifloxacin, Gemifloxacin, Ginkgo Biloba, Goldenseal, Gonadorelin, Goserelin, Granisetron, Halofantrine, Haloperidol, Histrelin, Hydroquinidine, Ibutilide, Idelalisib, Iloperidone, Imatinib, Imipramine, Indinavir, Isoniazid, Itraconazole, Ivabradine, Lapatinib, Leuprolide, Levofloxacin, Lithium, Lopinavir, Lumefantrine, Mefloquine, Methadone, Metronidazole, Miconazole, Mifepristone, Mizolastine, Moxifloxacin, Nafarelin, Nefazodone, Nelfinavir, Netupitant, Nilotinib, Norfloxacin, Nortriptyline, Octreotide, Ofloxacin, Ondansetron, Paliperidone, Paroxetine, Pasireotide, Pazopanib, Pentamidine, Perflutren Lipid Microsphere, Perphenazine, Pipamperone, Probucol, Procainamide, Prochlorperazine, Promethazine, Propafenone, Protriptyline, Quetiapine, Quinidine, Quinine, Ranitidine, Ranolazine, Rilpivirine, Risperidone, Ritonavir, Salmeterol, Selegiline, Sertindole, Sevoflurane, Sodium Phosphate, Sodium Phosphate, Dibasic, Sodium Phosphate, Monobasic, Solifenacin, Sorafenib, Sotalol, Sunitinib, Tacrolimus, Tamoxifen, Telaprevir, Telavancin, Telithromycin, Terfenadine, Tetrabenazine, Ticagrelor, Tizanidine, Tolterodine, Toremifene, Trazodone, Trifluoperazine, Trimipramine, Triptorelin, Vandetanib, Vardenafil, Vemurafenib, Venlafaxine, Verapamil, Vilanterol, Vinflunine, Voriconazole, Vorinostat, Delavirdine, Desipramine, Deslorelin, Diltiazem, Disopyramide, Dofetilide, Dolasetron, Doxepin, Droperidol, Ebastine, Eribulin, Erythromycin, Escitalopram, Famotidine, Felbamate, Fingolimod, Flecainide, Fluoxetine, Fluvoxamine, Formoterol, Fosamprenavir, Fosaprepitant, Foscarnet, Fosphenytoin, Galantamine, Gatifloxacin, Gemifloxacin, Ginkgo Biloba, Goldenseal, Gonadorelin, Goserelin, Granisetron, Halofantrine, Haloperidol, Histrelin, Hydroquinidine, Ibutilide, Idelalisib, Iloperidone, Imatinib, Imipramine, Indinavir, Isoniazid, Itraconazole, Ivabradine, Lapatinib, Leuprolide, Levofloxacin, Lithium, Lopinavir, Lumefantrine, Mefloquine, Methadone, Metronidazole, Miconazole, Mifepristone, Mizolastine, Moxifloxacin, Nafarelin, Nefazodone, Nelfinavir, Netupitant, Nilotinib, Norfloxacin, Nortriptyline, Octreotide, Ofloxacin, Ondansetron, Paliperidone, Paroxetine, Pasireotide, Pazopanib, Pentamidine, Perflutren Lipid Microsphere, Perphenazine, Pipamperone, Probucol, Procainamide, Prochlorperazine, Promethazine, Propafenone, Protriptyline, Quetiapine, Quinidine, Quinine, Ranitidine, Ranolazine, Rilpivirine, Risperidone, Ritonavir, Salmeterol, Selegiline, Sertindole, Sevoflurane, Sodium Phosphate, Sodium Phosphate, Dibasic, Sodium Phosphate, Monobasic, Solifenacin, Sorafenib, Sotalol, Sunitinib, Tacrolimus, Tamoxifen, Telaprevir, Telavancin, Telithromycin, Terfenadine, Tetrabenazine, Ticagrelor, Tizanidine, Tolterodine, Toremifene, Trazodone, Trifluoperazine, Trimipramine, Triptorelin, Vandetanib, Vardenafil, Vemurafenib, Venlafaxine, Verapamil, Vilanterol, Vinflunine, Voriconazole, Vorinostat. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Does food or alcohol interact with domperidone?

Domperidone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with domperidone?

Domperidone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Bleeding from the stomach or other problems involving the bowels;
  • Pituitary (brain) tumor;
  • Liver disease;
  • Medicine sensitivity to domperidone.

Understand the dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using domperidone.

What is the dose of domperidone for an adult?

Nausea and vomiting:

  • Adult:10-20 mg, oral,  every 4-8 hr. Max: 80 mg/day;
  • Adult:60 mg bid, rectal;

Non-ulcer dyspepsia

Adult: 10-20 mg, oral,  tid and at night.

Migraine
Adult: 20 mg every 4 hr, oral, in combination with paracetamol, as required. Max: 4 doses in 24 hr.

What is the dose of domperidone for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

Nausea and vomiting

  • Child:>2 yr and >35 kg: 10-20 mg, oral,  3-4 times daily. Max: 80 mg daily.
  • Child:60 mg bid, rectal.

How is domperidone available?

Domperidone is available in the following dosage forms and strengths: Tablet, Oral: 10 mg.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of domperidone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 4, 2017 | Last Modified: January 4, 2017

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