Dobutamine

By Medically reviewed by hellodoktor

Generic Name: Dobutamine Brand Name(s): Generics only. No brands available.

Uses

What is dobutamine used for?

Dobutamine is an inotropic agent. It works by increasing the strength and force of the heartbeat, causing more blood to circulate through the body.

Dobutamine is commonly used for treating heart failure caused by surgery or heart disease.

It may also be used for other conditions ask your doctor for more information.

How should I take dobutamine?

Use dobutamine as directed by your doctor. Ask your health care provider any questions you may have about how to use dobutamine.

Dobutamine is administered as an injection at your doctor’s office, hospital, or clinic.

If dobutamine contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.

Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.

How do I store dobutamine?

Dobutamine is usually handled and stored by a health care provider. If you are using dobutamine at home, store it as directed by your doctor. Keep dobutamine out of the reach of children and away from pets.

Precautions & warnings

What should I know before using dobutamine?

Before using dobutamine, tell your doctor if:

  • You are allergic to any ingredient in dobutamine.
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • Dobutamine may turn pink after exposure to light. This is normal and not a cause for concern.

Some of these products contain sulfites, which can cause allergic reactions in certain individuals (e.g., asthma patients). If you have previously had allergic reactions to sulfites, contact your pharmacist to determine if the product you are taking contains sulfites.

Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using dobutamine.

Lab tests, including blood potassium levels, blood pressure, and heart rate, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using dobutamine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking dobutamine. Dobutamine is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from dobutamine?

Check with your doctor if any of these most common side effects persist or become bothersome:

  • Headache
  • Nausea

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Chest pain
  • Fainting, dizziness, or lightheadedness
  • Fast or irregular heartbeat
  • Pounding in the chest
  • Shortness of breath

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with dobutamine?

Dobutamine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, such as:

  • Cimetidine or methyldopa, because side effects of dobutamine may be increased.
  • Catechol-O-methyltransferase (COMT) inhibitors (e.g., entacapone) or droxidopa, because actions and side effects may be increased by dobutamine.

Does food or alcohol interact with dobutamine?

Dobutamine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with dobutamine?

Dobutamine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions may include:

  • An irregular heartbeat
  • Low blood volume levels
  • Diabetes
  • High blood pressure
  • History of heart valve problems
  • An adrenal gland tumor
  • An increased irregular heartbeat (tachyarrhythmia)
  • An enlarged left ventricle of the heart due to narrowing of the aortic blood vessel (idiopathic hypertrophic subaortic stenosis)

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using dobutamine.

What is the dose of dobutamine for an adult?

Cardiac Decompensation

The recommended dose is 0.5-1 mcg/kg/min IV continuous infusion initially, then 2-20 mcg/kg/min; not to exceed 40 mcg/kg/min.

Low Cardiac Output (Off-label)

The recommended dose is 2-20 mcg/kg/min IV or IO; titrate to desired effect; not to exceed 40 mcg/kg/min.

What is the dose of dobutamine for a child?

Cardiac Decompensation

The recommended dose is 0.5-1 mcg/kg/min IV continuous infusion initially, then 2-20 mcg/kg/min; not to exceed 40 mcg/kg/min.

How is dobutamine available?

Dobutamine is available in the following dosage forms and strengths:

Dobutamine infusion solution, in D5W

  • 100mg/100Ml
  • 200mg/100Ml
  • 400mg/100Ml

Dobutamine injectable solution

  • 5mg/mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of dobutamine, contact your doctor immediately.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: April 5, 2017 | Last Modified: September 12, 2019

Sources
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