By Medically reviewed by hellodoktor

Generic Name: Direxiode Brand Name(s): Direxiode.


What is Direxiode® (Di-iodohydroxyquinolin) used for?

Direxiode® is commonly used to treat certain parasite infections of the intestines including amoebiasis, amoebic liver abscess, and giardiasis. It is not recommended to treat diarrhea of an unknown cause.

Direxiode® may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Direxiode® (Di-iodohydroxyquinolin)?

You should take Direxiode® by mouth after meals to minimize possible gastrointestinal irritation.

It is advisable not to not crush, break, or chew the tablets. Swallow Direxiode® tablets whole with a glass of water.

Ask your health care provider any questions you may have about how to use Direxiode®.

How do I store Direxiode® (Di-iodohydroxyquinolin)?

Direxiode® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Direxiode® in the bathroom or the freezer. There may be different brands of Direxiode® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Direxiode® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Direxiode® (Di-iodohydroxyquinolin)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Direxiode® or other medications.
  • You have any other illnesses, disorders, or medical conditions, such as: hepatic and kidney disorders blurred vision or loss of vision.
  • You have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Please note these information:

  • The treatment with Direxiode® should not last more than 4 weeks.
  • Using Direxiode® may cause mistakes in the thyroid function test.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category X, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Avoid using in nursing women.

Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding.

Side effects

What side effects can occur from Direxiode® (Di-iodohydroxyquinolin)?

Here are side effects:

  • Fever
  • Chills
  • Allergic reaction including rash, itching/swelling (especially of the face/tongue/throat)
  • Severe dizziness
  • Trouble breathing
  • Thyroid gland enlargement
  • Optic atrophy
  • Optic neuritis
  • Peripheral neuropathy
  • Subacute myelo-optic neuropathy

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.



What drugs may interact with Direxiode® (Di-iodohydroxyquinolin)?

Direxiode® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with Direxiode® including:

Does food or alcohol interact with Direxiode® (Di-iodohydroxyquinolin)?

Direxiode® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Direxiode® (Di-iodohydroxyquinolin)?

Direxiode® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Hepatic disease
  • Renal disease
  • Thyroid disease
  • Eye problems



The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Direxiode® (Di-iodohydroxyquinolin) for an adult?

Acute diarrhea

1 tablet; 2-3 times daily or as directed by your doctor; maximum 7 days.

Intestinal amebiasis

3 tablets; 3 times daily; maximum 20 days.

What is the dose of Direxiode® (Di-iodohydroxyquinolin) for a child?


Children > 30 month: 5-10 mg/kg/day; divided into 3-4 times.

Intestinal amebiasis

Children > 30 month: 5-10 mg/kg/day; divided into 3-4 times.

How is Direxiode® (Di-iodohydroxyquinolin) available?

Direxiode® is available in the following dosage forms and strengths:

  • Direxiode® Tablets Di-iodohydroxyquinoline 210 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

It is also important to carry a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking with you in case of emergencies.

What should I do if I miss a dose?

If you miss a dose of Direxiode®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: December 29, 2016 | Last Modified: September 13, 2019

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