Generic Name: Dipivefrin Brand Name(s): Generics only. No brands available.


What is dipivefrin used for?

Dipivefrin is a sympathomimetic. It works by decreasing fluid formation inside the eyeball and increasing fluid drainage from the eyeball, which helps lower pressure inside the eye.

Dipivefrin is commonly used for controlling inner eye pressure in patients with open-angle glaucoma. It may also be used for other conditions as determined by your doctor.

How should I take dipivefrin?

Ophthalmic dipivefrin comes as a solution (liquid) to instill in the eye. Dipivefrin eye drops are usually applied every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use dipivefrin eye drops exactly as directed. Do not use more or less of them or use them more often than prescribed by your doctor.

Dipivefrin eye drops control glaucoma but do not cure it. Continue to use dipivefrin eye drops even if you feel well. Do not stop using dipivefrin eye drops without talking to your doctor.

To instill the eye drops, follow these steps:

  • Wash your hands thoroughly with soap and water.
  • Check the dropper tip to make sure that it is not chipped or cracked.
  • Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.
  • While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.
  • Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.
  • Brace the remaining fingers of that hand against your face.
  • While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.
  • Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.
  • Place a finger on the tear duct and apply gentle pressure.
  • Wipe any excess liquid from your face with a tissue.
  • If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.
  • Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.
  • Wash your hands to remove any medication.

How do I store dipivefrin?

Dipivefrin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store dipivefrin in the bathroom or the freezer. There may be different brands of dipivefrin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush dipivefrin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using dipivefrin?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in dipivefrin.
  • You have narrow-angle glaucoma.
  • You are taking a beta-blocker (e.g., propranolol).
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • You have other eye problems (e.g., lens of your eye has been removed).

Is it safe during pregnancy or breastfeeding?


If you become pregnant, discuss with your doctor the benefits and risks of using dipivefrin during pregnancy.


It is unknown if dipivefrin is excreted in breast milk. If you are or will be breastfeeding while you are using dipivefrin, check with your doctor or pharmacist to discuss the risks to your baby.

Side effects

What side effects can occur from dipivefrin?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Blurred vision
  • Burning
  • Eye redness
  • Headache
  • Itching
  • Sensitivity to light
  • Stinging

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Decrease in vision
  • Eye pain
  • Fast heartbeat
  • Irregular heartbeat
  • Swelling of the eye or eyelids

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with dipivefrin?

Dipivefrin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Beta-blockers (e.g., propranolol), because the risk for side effects such as increased blood pressure or slow heartbeat may be increased.
  • Acebutolol, because dipivefrin may increase the atrioventricular blocking (AV block) activities of acebutolol.
  • Alfuzosin, because alfuzosin may decrease the vasoconstricting activities of dipivefrin.
  • Alprenolol, because alprenolol may decrease the bronchodilatory activities of dipivefrin.
  • Amineptine, because amineptine may decrease the antihypertensive activities of dipivefrin.
  • Amitriptyline, because amitriptyline may decrease the antihypertensive activities of dipivefrin.
  • Aop200704, because dipivefrin may increase the atrioventricular blocking (AV block) activities of Aop200704.
  • Arotinolol, because dipivefrin may increase the atrioventricular blocking (AV block) activities of arotinolol.
  • Atenolol, because dipivefrin may increase the atrioventricular blocking (AV block) activities of atenolol.
  • Atomoxetine, because atomoxetine may increase the tachycardic activities of dipivefrin.

Does food or alcohol interact with dipivefrin?

Dipivefrin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with dipivefrin?

Dipivefrin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using dipivefrin.

What is the dose of dipivefrin for an adult?

Initial glaucoma therapy

The usual dosage of dipivefrin is one drop in the eye(s) every 12 hours.

Addition of Dipivefrin ophthalmic solution

When patients on other antiglaucoma agents require additional therapy, add one drop of dipivefrin every 12 hours.

Concomitant Therapy

For difficult to control patients, the addition of PROPINE® (dipivefrin) ophthalmic solution to other agents such as pilocarpine, carbachol, echothiophate iodide or acetazolamide has been shown to be effective.

What is the dose of dipivefrin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is dipivefrin available?

Dipivefrin is available in the following dosage forms and strengths:

  • Dipivefrin solution, 0.1%, is supplied sterile in plastic dropper bottles as follows: 5 ml; 10 ml; 15 ml.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of dipivefrin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 18, 2017 | Last Modified: March 18, 2017

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