Difluprednate

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Generic Name: Difluprednate Brand Name(s): Difluprednate.

Uses

What is Difluprednate used for?

Difluprednate is commonly used to treat swelling and pain after eye surgery. It may also be used to treat a certain serious eye problem (endogenous anterior uveitis). This medication belongs to a class of drugs known as corticosteroids.

How should I take Difluprednate?

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

If you are wearing contact lenses, remove them before using eye drops. Wait at least 10 minutes before replacing your contact lenses.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place 1 drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed or if your dose is for more than 1 drop.

Do not rinse the dropper. Replace the dropper cap after each use.

Use this medication exactly as directed by your doctor. Your doctor may direct you to use this medication more often at the beginning of treatment and then reduce your dose gradually. Do not stop using this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day. Continue using it for the full time prescribed.

If you are using another kind of eye medication (for example, drops or ointments), wait at least 5 to 10 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.

Tell your doctor if your condition persists or does not improve.

How do I store Difluprednate?

Difluprednate is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Difluprednate in the bathroom or the freezer. There may be different brands of Difluprednate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Difluprednate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Difluprednate?

Before using difluprednate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current or past eye infection (including viral infections such as herpes simplex keratitis), cataracts, glaucoma.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if difluprednate passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Difluprednate during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this Difluprednate. This Difluprednate is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Difluprednate?

Temporary blurred vision may occur. If this effect persists or worsens, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Use of this medication for prolonged or repeated periods may result in a new fungal infection. Do not use this medication for longer than prescribed.

Tell your doctor right away if any of these unlikely but serious side effects occur: new or increased eye pain/swelling/discharge/redness, eye pain/discomfort in bright light, vision changes.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Difluprednate?

Difluprednate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Difluprednate?

Difluprednate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Difluprednate?

Difluprednate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Difluprednate.

What is the dose of Difluprednate for an adult?

Usual Adult Dose for Postoperative Ocular Inflammation

Instill 1 drop into the conjunctival sac of the affected eye 4 times per day beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period, followed by 2 times per day for a week and then a taper based on the response

Use: Treatment of inflammation and pain associated with ocular surgery

Usual Adult Dose for Uveitis

Instill 1 drop into the conjunctival sac of the affected eye 4 times per day for 14 days followed by tapering as clinically indicated

Use: Treatment of endogenous anterior uveitis

Other Comments

Patient advice:

-Patients should be advised not to allow the dropper tip to touch any surface.

Storage requirements:

-Do not freeze

-Protect from light

What is the dose of Difluprednate for a child?

Usual Pediatric Dose for Postoperative Ocular Inflammation

Instill 1 drop into the conjunctival sac of the affected eye 4 times per day beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period, followed by 2 times per day for a week and then a taper based on the response

Use: Treatment of inflammation and pain associated with ocular surgery

Usual Pediatric Dose for Uveitis

Instill 1 drop into the conjunctival sac of the affected eye 4 times per day for 14 days followed by tapering as clinically indicated

Use: Treatment of endogenous anterior uveitis

How is Difluprednate available?

Difluprednate is available in the following dosage forms and strengths:

  • Eye Drops

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Difluprednate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: January 22, 2018 | Last Modified: January 22, 2018

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