Diflucan

By Medically reviewed by hellodoktor

Generic Name: Diflucan Brand Name(s): Generics only. No brands available.

Uses

What is Diflucan® (fluconazole) used for?

Diflucan® is an azole antifungal. It is commonly used for preventing, treating a variety of fungal and yeast infections.

How should I take Diflucan® (fluconazole)?

For orally taken form, you should:

  • Take Diflucan® bymouth as directed by your doctor concerning: dose, schedule.
  • Read the label carefully before using Diflucan®.
  • Consult your doctor for any information on the label that you do not clearly understand.

How do I store Diflucan® (fluconazole)?

Diflucan® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Diflucan® in the bathroom or the freezer. There may be different brands of Diflucan® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Diflucan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

 

Precautions & warnings

What should I know before using Diflucan® (fluconazole)?

Before using Diflucan®, tell your doctor if you have:

  • Allergic reaction to excipients using for dosage form containing Diflucan®.
  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • Any other health conditions, drugs that have a risk of interaction with Diflucan®.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Diflucan® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Diflucan®. Diflucan® is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Diflucan® (fluconazole)?

As taking others medicines, taking Diflucan® can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of side effects are listed below:

  • Headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats
  • Flu symptoms (such as fever, chills, body aches)
  • Easy bruising or bleeding
  • Unusual weakness
  • Seizure (convulsions)
  • Liver problems (such as nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice)
  • Skin rash or skin lesions
  • Severe skin reaction (fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads and causes blistering and peeling)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Diflucan® (fluconazole)?

Diflucan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, such as:

  • Halofantrine
  • Prednisone
  • Theophylline
  • Tofacitinib
  • Vitamin A
  • An antidepressant (amitriptyline, nortriptyline)
  • Other antifungal medicine (amphotericin b or voriconazole)
  • Blood pressure medicine (hydrochlorothiazide, losartan, amlodipine, nifedipine, felodipine)
  • A blood thinner (warfarin, coumadin, jantoven)
  • Cancer medicine (cyclophosphamide, vincristine, vinblastine)
  • Cholesterol medicine (atorvastatin, simvastatin, fluvastatin)
  • HIV/AIDS medicine (saquinavir, zidovudine, and others)
  • Medicine to prevent organ transplant rejection (cyclosporine, tacrolimus or sirolimus)
  • Narcotic medicine (fentanyl, alfentanil, methadone)
  • NSAIDs (celecoxib, ibuprofen, naproxen)
  • Oral diabetes medicine (glyburide, tolbutamide, glipizide)
  • Seizure medicine (carbamazepine, phenytoin)
  • Tuberculosis medication (rifampin, rifabutin)

Does food or alcohol interact with Diflucan® (fluconazole)?

Diflucan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Diflucan® (fluconazole)?

Diflucan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Electrolyte problems (mineral imbalance)
  • Heart disease
  • Fructose intolerance (rare hereditary problem)
  • Galactose intolerance (rare hereditary problem).
  • Glucose-galactose malabsorption (rare hereditary problem)
  • Lapp lactase deficiency (rare hereditary problem)
  • Sucrase-isomaltase deficiency (rare hereditary problem)
  • Any condition that makes it hard for you to digest sugars or dairy products
  • Heart rhythm problems
  • Liver disease
  • Kidney disease
  • Cancer
  • Acquired immunodeficiency syndrome (AIDS);
  • A low level of calcium, sodium, magnesium, or potassium in your blood

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Diflucan® (fluconazole).

What is the dose of Diflucan® (fluconazole) for an adult?

Consult your doctor for information about the dose of Diflucan®.

Recommended doses in some cases are listed below:

Vaginal candidiasis:

150 mg orally as a single dose.

Oral thrush:

Oropharyngeal candidiasis: 200 mg orally on the first day followed by 100 mg orally once a day.
Duration of therapy: at least 2 weeks, to reduce the risk of relapse.

Candidemia:

Doses up to 400 mg/day have been used.

Fungal pneumonia:

Doses up to 400 mg/day have been used.

Fungal infection – disseminated:

Doses up to 400 mg/day have been used.

Systemic candidiasis:

Doses up to 400 mg/day have been used.

Esophageal candidiasis:

200 mg orally on the first day followed by 100 mg orally once a day.
Duration of therapy: at least 3 weeks and for at least 2 weeks after symptoms resolve.

Candida urinary tract infection:

50 to 200 mg orally once a day.

Fungal peritonitis:

50 to 200 mg orally once a day.

Cryptococcal meningitis – immunocompetent host:

Acute infection: 400 mg orally on the first day followed by 200 mg orally once a day. Duration of therapy: 10 to 12 weeks after CSF culture is negative.

Cryptococcal meningitis – immunosuppressed host: 

Acute infection: 400 mg orally on the first day followed by 200 mg orally once a day. Duration of therapy: 10 to 12 weeks after CSF culture is negative.

Cryptococcosis

IDSA recommendations: mild to moderate pulmonary infection and non-meningeal, non-pulmonary infection if CNS disease ruled out, no fungemia, single site of infection, no immunosuppressive risk factors: 400 mg orally once a day for 6 to 12 months.

Fungal infection prophylaxis:

400 mg orally once a day.

Duration of therapy: 7 days after neutrophil count rises above 1000 cells/mm3.

Coccidioidomycosis – meningitis:

IDSA recommendations: 400 mg orally once a day.

Coccidioidomycosis:

IDSA recommendations: 400 to 800 mg orally once a day.

Histoplasmosis:

IDSA recommendations:

  • Disseminated infections in patients without AIDS: 200 to 800 mg orally once a day for at least 12 months.
  • CNS infection (after initial regimen of IV amphotericin B): 200 to 400 mg orally once a day for 12 months.

Blastomycosis:

  • IDSA recommendations: mild to moderate pulmonary infection or mild to moderate disseminated infection without CNS involvement: 400 to 800 mg orally once a day for at least 6 to 12 months.
  • CNS infection (after initial regimen of IV amphotericin B): 800 mg orally once a day for at least 12 months and until CSF abnormalities resolve.

Onychomycosis – fingernail:

  • Some experts recommend: 150 to 300 mg orally once a week. Duration of therapy:
  • Fingernail infections: 3 to 6 months
  • Toenail infections: 6 to 12 months

Onychomycosis – Toenail:

Some experts recommend: 150 to 300 mg orally once a week. Duration of therapy:

  • Fingernail infections: 3 to 6 months
  • Toenail infections: 6 to 12 months

Sporotrichosis:

IDSA recommendations:

  • Cutaneous or lymphocutaneous infection: 400 to 800 mg orally once a day.
  • Duration of therapy: 2 to 4 weeks after all lesions resolve (usually 3 to 6 months total).

What is the dose of Diflucan® (fluconazole) for a child?

Consult your doctor for information about the dose of Diflucan®.

Recommended doses in some cases are listed below:

Esophageal candidiasis:

2 weeks or younger (gestational age 26 to 29 weeks): 3 mg/kg orally every 72 hours.

  • Older than 2 weeks: 6 mg/kg orally on the first day followed by 3 mg/kg Orally once a day.
  • Duration of therapy: at least 3 weeks and for at least 2 weeks after symptoms resolve.

Oral thrush:

Oropharyngeal candidiasis:

  • 2 weeks or younger (gestational age 26 to 29 weeks): 3 mg/kg orally every 72 hours.
  • Older than 2 weeks: 6 mg/kg orally on the first day followed by 3 mg/kg orally once a day.
  • Duration of therapy: at least 2 weeks, to reduce the risk of relapse.

Candidemia:

  • 2 weeks or younger (gestational age 26 to 29 weeks): 6 to 12 mg/kg orally every 72 hours.
  • Older than 2 weeks: 6 to 12 mg/kg/day orally.

Fungal infection – disseminated:

  • 2 weeks or younger (gestational age 26 to 29 weeks): 6 to 12 mg/kg orally every 72 hours.
  • Older than 2 weeks: 6 to 12 mg/kg/day orally.

Systemic candidiasis:

  • 2 weeks or younger (gestational age 26 to 29 weeks): 6 to 12 mg/kg orally every 72 hours;
  • Older than 2 weeks: 6 to 12 mg/kg/day orally.

Cryptococcal meningitis – immunocompetent host:

Acute infection:

  • 2 weeks or younger (gestational age 26 to 29 weeks): 6 mg/kg orally every 72 hours.
  • Older than 2 weeks: 12 mg/kg orally on the first day followed by 6 mg/kg orally once a day
  • Duration of therapy: 10 to 12 weeks after CSF culture is negative.

Cryptococcal meningitis – immunosuppressed host:

Acute infection:

  • 2 weeks or younger (gestational age 26 to 29 weeks): 6 mg/kg orally every 72 hours.
  • Older than 2 weeks: 12 mg/kg orally on the first day followed by 6 mg/kg Orally once a day.
  • Duration of therapy: 10 to 12 weeks after CSF culture is negative.

Cryptococcosis:

IDSA recommendations for children:

  • Disseminated disease:
  • Consolidation therapy (after induction therapy): 10 to 12 mg/kg/day orally in 2 divided doses for 8 weeks.
  • Maintenance therapy in HIV-infected patients: 6 mg/kg orally once a day
    cryptococcal pneumonia: 6 to 12 mg/kg orally once a day for 6 to 12 months.

Fungal infection prophylaxis:

IDSA recommendations:

  • Empiric therapy for suspected candidiasis in non-neutropenic or neutropenic patients: 12 mg/kg orally on the first day followed by 6 mg/kg orally once a day.

Candida urinary tract infection:

IDSA recommendations:

  • Asymptomatic cystitis in patients undergoing urologic procedures: 3 to 6 mg/kg orally once a day for several days before and after the procedure.
  • Symptomatic cystitis: 3 mg/kg orally once a day for 2 weeks.
  • Pyelonephritis: 3 to 6 mg/kg orally once a day for 2 weeks.
  • Urinary fungus balls: 3 to 6 mg/kg orally once a day until symptoms resolve and urine cultures clear of Candida.

Coccidioidomycosis – meningitis:

US CDC, NIH, IDSA, PIDS, and AAP Recommendations for HIV-exposed and HIV-infected Children:

  • Meningeal infection: 12 mg/kg orally once a day
  • Maximum dose: 800 mg/dose
  • Secondary prophylaxis: 6 mg/kg orally once a day
  • Maximum dose: 400 mg/dose
  • Duration of therapy: lifelong

Coccidioidomycosis:

US CDC, NIH, IDSA, PIDS, and AAP Recommendations for HIV-exposed and HIV-infected Children:

  • Severe illness with respiratory compromise due to diffuse pulmonary or disseminated non-meningeal infection: 12 mg/kg orally once a day.
  • maximum dose: 800 mg/dose
  • Duration of therapy: 1 year total
  • Mild to moderate non-meningeal infection (e.g., focal pneumonia): 6 to 12 mg/kg orally once a day. Maximum dose: 400 mg/dose.
  • Secondary prophylaxis: 6 mg/kg orally once a day.
  • Maximum dose: 400 mg/dose
  • Duration of therapy: lifelong in patients with disseminated disease

Vaginal candidiasis:

US CDC, NIH, and IDSA Recommendations for HIV-infected Adolescents:

  • Uncomplicated vulvovaginal candidiasis: 150 mg orally as a single dose.
  • Severe or recurrent vulvovaginal candidiasis: 100 to 200 mg orally once a day for at least 7 days.
  • Suppressive therapy for vulvovaginal candidiasis: 150 mg orally once a week.

Histoplasmosis:

US CDC, NIH, IDSA, PIDS, and AAP Recommendations for HIV-exposed and HIV-infected Children:

  • Acute primary pulmonary infection: 3 to 6 mg/kg orally once a day. Maximum dose: 200 mg/dose.
  • Mild disseminated disease: 5 to 6 mg/kg orally twice a day.
  • Maximum dose: 300 mg/dose
  • Duration of therapy: 12 months
  • Secondary prophylaxis: 3 to 6 mg/kg orally once a day. Maximum dose: 200 mg/dose.

How is Diflucan® (fluconazole) available?

Diflucan® is available in the following dosage forms and strengths:

  • Tablet, Oral: 50 mg, 100 mg, 150 mg, 200 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Diflucan®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 7, 2017 | Last Modified: September 12, 2019

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