Generic Name: Dextropropoxyphen Brand Name(s): Generics only. No brands available.


What is dextropropoxyphene used for?

Dextropropoxyphene is in a group of drugs called narcotic pain relievers. It is used to relieve mild to moderate pain.

Dextropropoxyphene may also be used for purposes; ask your doctor for more information.

How should I take dextropropoxyphene?


  • Take this product by mouth as directed. Follow all directions on the product package.
  • If you are uncertain about any of the information, consult your doctor or pharmacist.

How do I store dextropropoxyphene?

Dextropropoxyphene is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store dextropropoxyphene in the bathroom or the freezer. There may be different brands of dextropropoxyphene that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.                           You should not flush dextropropoxyphene down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using dextropropoxyphene?

Do not use propoxyphene if you have a history of suicidal thoughts or actions. Propoxyphene should never be taken together with a sedative (such as Valium or Xanax) or an antidepressant if you are also drinking large amounts of alcohol. Propoxyphene may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. Do not drink alcohol while you are taking propoxyphene. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine. Check your food and medicine labels to be sure these products do not contain alcohol.

Never take more than your prescribed dose of propoxyphene. Tell your doctor if the medicine seems to stop working as well in relieving your pain. Propoxyphene can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not stop using propoxyphene suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Is it safe during pregnancy or breastfeeding?


There are no adequate studies in women for determining risk when using dextropropoxyphene during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking dextropropoxyphene. Dextropropoxyphene is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Dextropropoxyphene passes into breast milk and could harm a nursing baby. Do not use dextropropoxyphene without telling your doctor if you are breastfeeding a baby.

Side effects

What side effects can occur from dextropropoxyphene?

Get emergency medical help if you have any of these signs of an allergic reaction to propoxyphene: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • Shallow breathing
  • Slow heartbeat
  • Feeling light-headed
  • Fainting
  • Confusion
  • Hallucinations
  • Unusual thoughts or behavior
  • Seizure (convulsions)
  • Jaundice (yellowing of the skin or eyes)

Less serious side effects include:

  • Feeling dizzy or drowsy
  • Nausea
  • Vomiting
  • Stomach pain
  • Constipation
  • Headache
  • Muscle pain
  • Blurred vision
  • Mild skin rash

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with dextropropoxyphene?

Dextropropoxyphene may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, such as:

  • Narcotic pain medications
  • Sedatives
  • Tranquilizers
  • Muscle relaxers
  • Other medicines that can make you sleepy or slow your breathing
  • Amiodarone (Cordarone, Pacerone)
  • Aprepitant (Emend)
  • Bosentan (Tracleer)
  • Conivaptan (Vaprisol)
  • Dexamethasone (Decadron, Hexadrol)
  • Imatinib (Gleevec)
  • Isoniazid (for treating tuberculosis)
  • John’s wort
  • An antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), rifampin (Rifadin, Rifater, Rifamate), or telithromycin (Ketek)
  • Antifungal medication such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend)
  • An antidepressant such as nefazodone
  • A barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton)
  • A blood thinner such as warfarin (Coumadin)
  • Heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others
  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir)
  • Medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil)
  • Seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline)


Does food or alcohol interact with dextropropoxyphene?

Dextropropoxyphene may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.


What health conditions may interact with dextropropoxyphene?

Dextropropoxyphene may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Asthma, COPD, sleep apnea, or other breathing disorders
  • Liver or kidney disease
  • A history of head injury or brain tumor
  • Mental illness
  • A history of drug or alcohol addiction


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using dextropropoxyphene.

What is the dose of dextropropoxyphene for an adult?

The recommended dose is 65 mg (HCl) orally every 4 hours as needed or
100 mg (Napsylate) orally every 4 hours as needed.

What is the dose of dextropropoxyphene for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is dextropropoxyphene available?

Dextropropoxyphene is available in the following dosage forms and strengths:

  • Tablet 65mg
  • Oral suspension 50 mg/5 ml.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

Overdose symptoms may include extreme drowsiness, pinpoint or dilated pupils, confusion, cold and clammy skin, blue lips, weak pulse, slow or uneven heart rate, shallow breathing, fainting, or breathing that stops.

What should I do if I miss a dose?

If you miss a dose of dextropropoxyphene, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 21, 2017 | Last Modified: February 6, 2017

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