By Medically reviewed by hellodoktor

Generic Name: Depersolon Brand Name(s): Generics only. No brands available.


What is Depersolon® (mazipredone hydrochloride) used for?

Depersolon® is commonly used for treating or preventing these followings, such as:

  • The acute syndrome which required glycocorticoid injection therapy such as shock after burns, trauma, surgery or infection
  • Shock phase myocardial infarction
  • Severe allergic reaction
  • Anaphylaxis
  • Shock due to blood transfusion
  • Acute asthma
  • Severe hypersensitivity to the drug
  • Development status poisoning as a result of infectious diseases (prolonged corticoid use under the protection of appropriate antibiotic)
  • Adrenal impairment level (e.g., acute Addison, Waterhouse-Fridrichsen syndrome)
  • Low pressure during anesthesia for patients with chronic adrenal failure caused by prolonged treatment with steroids
  • Hepatic coma

How should I take Depersolon® (mazipredone hydrochloride)?

This drug is injected by your doctor through intravenous.

How do I store Depersolon® (mazipredone hydrochloride)?

Depersolon® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Depersolon® in the bathroom or the freezer. There may be different brands of Depersolon® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Depersolon® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Depersolon® (mazipredone hydrochloride)?

Depersolon® is contraindicated in case of:

  • During immunization vaccine
  • Duodenal ulcer
  • Osteoporosis
  • Cushing’s syndrome
  • Tendency to thrombosis
  • Renal failure
  • High blood pressure
  • Herpes simplex
  • Chickenpox
  • Lao progress

In latent TB, this medicine is used together with drug-resistant tuberculosis.

In diabetes, the drug is used only in cases specified in absolute or to reserve insulin resistance.

In infectious diseases, drugs must be used with caution with use of chemotherapy and specific antibiotic therapy.

Glycocorticoid relatively contraindicated use during pregnancy, especially during the first 3 months, because it can harm the fetus, the ratio of profit / loss should be considered.

In cases of danger to life, if possible, intravenous is recommended.

If long-term treatment, compensation is absolutely required potassium, to prevent hypoglycemia can have high blood potassium.

To prevent risk of degeneration and osteoporosis, should be used concurrently with Nerobol (Neroboletta).

During treatment, so regular blood pressure, urine testing, and distributed as needed.

Treatment period ends, to reduce the dose gradually.

Should adjust the dose of anti-diabetic drugs (type of drink) and anticoagulants used during corticoid.

If used concurrently with diuretics, must check the internal electrolyte balance each (offset potassium).

In the case of salicylates concomitantly with, should reduce both doses (low doses of corticoids to reduce the concentration of salicylate to the lower level).

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Depersolon® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Depersolon®.

Side effects

What side effects can occur from Depersolon® (mazipredone hydrochloride)?

When intramuscularly, sensitive spot (transient pain) and infiltration can occur.

In long-term treatment, these side effects may occur:

  • Resistance to bacterial reduction
  • High blood pressure
  • Glucose, urine, blood potassium decreased
  • Negative nitrogen balance (catabolism)
  • Shell adrenal failure
  • Osteoporosis
  • Increased acid secretion
  • Ulcer

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Depersolon® (mazipredone hydrochloride)?

Depersolon® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with your drug, such as:

  • Addison barbiturates (which can lead to acute)
  • Cardiac glycoside assistance (increase each other’s effects)
  • Anti-drinking type of diabetes (blood glucose lowering risk)
  • Anticoagulants (increased anticoagulant effect)
  • Salicylate (salicylate plasma concentrations can be reduced, increasing the risk of unwanted effects, such as bleeding)
  • Barbiturate (corticoid effects can be reduced)
  • Diuretics (decreased blood potassium)
  • Nonsteroidal anti-inflammatory drugs (risk of gastrointestinal bleeding)

Does food or alcohol interact with Depersolon® (mazipredone hydrochloride)?

Depersolon® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Depersolon® (mazipredone hydrochloride)?

Depersolon® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Depersolon® (mazipredone hydrochloride).

What is the dose of Depersolon® (mazipredone hydrochloride) for an adult?


The recommended dose is infusion or IV slowly 30-90mg (1-3 ampoules).

In emergency, it can increase dosage from 150 to 300mg (3-5 ampoules).

Another indication: The recommended dose is 30-45mg (1-1,5 ampoules) IV slowly or IM.

What is the dose of Depersolon® (mazipredone hydrochloride) for a child?


The recommended dose is infusion or IV slowly (3 minutes).

Child 1-4 years: The recommended dose is 1-2mg/kg.

Child 2-12 month: The recommended dose is 2-3 mg/kg.

How is Depersolon® (mazipredone hydrochloride) available?

Depersolon® is available in the following dosage forms and strengths:

  • Injectable; Injection; Mazipredone Hydrochloride 30 mg / ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Depersolon®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: April 1, 2017 | Last Modified: September 12, 2019

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