Depamide

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Generic Name: Depamide Brand Name(s): Generics only. No brands available.

Uses

What is Depamide® (valpromide) used for?

Depamide® is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures.

Depamide® is also indicated for use as sole and adjunctive therapy in the treatment of patients with simple and complex absence seizures, and adjunctively in patients with multiple seizure types that include absence seizures.

How should I take Depamide® (valpromide)?

Depamide® sodium injection is for intravenous use only.

How do I store Depamide® (valpromide)?

Depamide® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Depamide® in the bathroom or the freezer. There may be different brands of Depamide® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Depamide® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Depamide® (valpromide)?

Before using this drug, tell your doctor if:

  • You are pregnant, planning to become pregnant, are breastfeeding, or are of childbearing age.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • You have decreased food or fluid intake, or if you are scheduled for surgery.
  • You have a family history of urea cycle disorders or unexplained infant deaths.
  • You take any other medicine for seizures.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Depamide® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Depamide®.

Side effects

What side effects can occur from Depamide® (valpromide)?

When using this drug, consult your doctor if you have some common side effects, such as:

  • Black, tarry stools
  • Bleeding gums
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • Blood in the urine or stools
  • Confusion
  • Cough or hoarseness
  • Crying
  • Delusions
  • Dementia
  • Depersonalization
  • Diarrhea
  • Difficult or labored breathing
  • Dysphoria
  • Euphoria
  • Fever or chills
  • General feeling of discomfort or illness
  • Headache
  • Joint pain
  • Loss of appetite
  • Lower back or side pain
  • Mental depression
  • Muscle aches and pains
  • Nausea
  • Nervousness
  • Painful or difficult urination
  • Paranoia
  • Pinpoint red spots on the skin
  • Quick to react or overreact emotionally
  • Rapid weight gain
  • Rapidly changing moods
  • Runny nose
  • Shakiness in the legs, arms, hands, or feet
  • Shivering
  • Sleepiness or unusual drowsiness
  • Sore throat
  • Sweating
  • Tightness in the chest
  • Tingling of the hands or feet
  • Trembling or shaking of the hands or feet
  • Trouble sleeping
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Unusual weight gain or loss
  • Vomiting

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Depamide® (valpromide)?

Depamide® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

·         Aspirin

·         Carbapenem Antibiotics

·         Felbamate

·         Rifampin

·         Antacids

·         Chlorpromazine

·         Haloperidol

·         Cimetidine and Ranitidine

·         Amitriptyline/Nortriptyline

·         Carbamazepine/carbamazepine-10,11-Epoxide

·         Clonazepam

·         Diazepam

·         Ethosuximide

·         Phenobarbital

·         Phenytoin

·         Rufinamide

·         Tolbutamide

·         Warfarin

·         Zidovudine

·         Acetaminophen

·         Clozapine

·         Lithium

·         Lorazepam

·         Olanzapine

·         Oral Contraceptive Steroids

·         Topiramate

·         Lamotrigine


Does food or alcohol interact with Depamide® (valpromide)?

Depamide® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Depamide® (valpromide)?

Depamide® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • A history of liver problems
  • Cancer
  • Blood disease (e.g., low levels of white blood cells, low blood platelet levels)
  • HIV infection
  • Cytomegalovirus (CMV) infection
  • Kidney problems
  • Pancreas problems
  • Low blood albumin levels
  • High blood glycine levels
  • A history of metabolic problems
  • Ornithine transcarbamylase deficiency
  • Brain problems (e.g., organic brain disease)
  • Coma
  • High blood ammonia or glutamine levels
  • Low body temperature
  • Mental retardation
  • Recurring vomiting and sluggishness
  • Recurring extreme irritability
  • A history of mental or mood problems
  • Suicidal thoughts or actions
  • Alcohol abuse

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Depamide® (valpromide).

What is the dose of Depamide® (valpromide) for an adult?

Epilepsy

Depamide® sodium injection should be administered as a 60 minute infusion (but not more than 20 mg/‌min) with the same frequency as the oral products, although plasma concentration monitoring and dosage adjustments may be necessary.

Monotherapy (Initial Therapy)

Patients should initiate therapy at 10 to 15 mg/kg/day. The dosage should be increased by 5 to 10 mg/kg/week to achieve optimal clinical response. Ordinarily, optimal clinical response is achieved at daily doses below 60 mg/kg/day.

If satisfactory clinical response has not been achieved, plasma levels should be measured to determine whether or not they are in the usually accepted therapeutic range (50 to 100 mcg/ml). No recommendation regarding the safety of Depamide® for use at doses above 60 mg/kg/day can be made.

Conversion to Monotherapy

Patients should initiate therapy at 10 to 15 mg/kg/day. The dosage should be increased by 5 to 10 mg/kg/week to achieve optimal clinical response. Ordinarily, optimal clinical response is achieved at daily doses below 60 mg/kg/day. If satisfactory clinical response has not been achieved, plasma levels should be measured to determine whether or not they are in the usually accepted therapeutic range (50-100 mcg/ml).

Adjunctive Therapy

Depamide® sodium injection may be added to the patient’s regimen at a dosage of 10 to 15 mg/‌kg/‌day. The dosage may be increased by 5 to 10 mg/kg/week to achieve optimal clinical response. Ordinarily, optimal clinical response is achieved at daily doses below 60 mg/kg/day. If satisfactory clinical response has not been achieved, plasma levels should be measured to determine whether or not they are in the usually accepted therapeutic range (50 to 100 mcg/mL). No recommendation regarding the safety of Depamide® (valpromide) for use at doses above 60 mg/kg/day can be made. If the total daily dose exceeds 250 mg, it should be given in divided doses.

Simple and Complex Absence Seizures

The recommended initial dose is 15 mg/kg/day, increasing at one week intervals by 5 to 10 mg/‌kg/‌day until seizures are controlled or side effects preclude further increases. The maximum recommended dosage is 60 mg/kg/day. If the total daily dose exceeds 250 mg, it should be given in divided doses.

Replacement Therapy

When switching from oral Depamide® products, the total daily dose of Depamide® sodium injection should be equivalent to the total daily dose of the oral Depamide® product, and should be administered as 60minutes infusion (but not more than 20 mg/min) with the same frequency as the oral products, although plasma concentration monitoring and dosage adjustments may be necessary.

Patients receiving doses near the maximum recommended daily dose of 60 mg/kg/day, particularly those not receiving enzyme-inducing drugs, should be monitored more closely. If the total daily dose exceeds 250 mg, it should be given in a divided regimen.

Dosing in Elderly Patients

Due to a decrease in unbound clearance of Depamide® (valpromide) and possibly a greater sensitivity to somnolence in the elderly, the starting dose should be reduced in these patients. Dosage should be increased more slowly and with regular monitoring for fluid and nutritional intake, dehydration, somnolence, and other adverse reactions. Dose reductions or discontinuation of Depamide® (valpromide) should be considered in patients with decreased food or fluid intake and in patients with excessive somnolence. The ultimate therapeutic dose should be achieved on the basis of both tolerability and clinical response.

What is the dose of Depamide® (valpromide) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Depamide® (valpromide) available?

Depamide® is available in the following dosage forms and strengths:

  • Depamide® Sodium Injection, USP, equivalent to 100 mg of valproic acid per mL, is a clear, colorless solution in 5 mL single dose vials, available in trays of 10 vials.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room. Symptoms of overdose may include change in consciousness, fainting, loss of consciousness, and slow or irregular heartbeat.

What should I do if I miss a dose?

If you miss a dose of Depamide®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 21, 2017 | Last Modified: March 21, 2017

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