Darifenacin

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Generic Name: Darifenacin Brand Name(s): Darifenacin.

Uses

What is Darifenacin used for?

Darifenacin is commonly used to treat an overactive bladder. By relaxing the muscles in the bladder, darifenacin improves your ability to control your urination. It helps to reduce leaking of urine, feelings of needing to urinate right away, and frequent trips to the bathroom. This medication belongs to the class of drugs known as antispasmodics.

How should I take Darifenacin?

Take this medication by mouth with or without food as directed by your doctor, usually once a day. Swallow this medication with a full glass of water (8 ounces/240 milliliters).

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if your condition does not improve or if it worsens.

How do I store Darifenacin?

Darifenacin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Darifenacin in the bathroom or the freezer. There may be different brands of Darifenacin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Darifenacin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Darifenacin?

Before taking darifenacin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: difficulty urinating (urinary retention), other bladder problems (such as bladder outflow obstruction), stomach/intestinal blockage (gastric retention), liver disease, personal or family history of glaucoma (angle-closure type), bowel disease (such as ulcerative colitis), slowed movement of stomach/intestines, constipation, enlarged prostate, a certain muscle/nerve disease (myasthenia gravis).

This drug may make you dizzy or blur your vision. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Darifenacin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this Darifenacin. This Darifenacin is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Darifenacin?

Dry mouth, constipation, nausea, stomach upset, stomach pain, blurred vision, dry eyes, dizziness, or weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while using this drug, consult your pharmacist for help in selecting a laxative.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: severe stomach/abdominal pain, constipation for 3 or more days, difficulty urinating, signs of kidney infection (such as burning/painful/frequent urination, fever, pink/bloody urine), mental/mood changes (such as confusion, hallucinations).

Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Darifenacin?

Some products that may interact with this drug include: pramlintide, potassium tablets/capsules.

Darifenacin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Darifenacin?

Darifenacin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Darifenacin?

Darifenacin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Darifenacin.

What is the dose of Darifenacin for an adult?

Usual Adult Dose for Urinary Incontinence

Initial dose: 7.5 mg orally once a day

Maintenance dose: The dosage may be increased to 15 mg orally once a day as early as 2 weeks after starting therapy

Comments:

-This drug may be taken with or without food.

-The tablet should be swallowed whole with water and not chewed, divided, or crushed.

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency

Usual Adult Dose for Urinary Frequency

Initial dose: 7.5 mg orally once a day

Maintenance dose: The dosage may be increased to 15 mg orally once a day as early as 2 weeks after starting therapy

Comments:

-This drug may be taken with or without food.

-The tablet should be swallowed whole with water and not chewed, divided, or crushed.

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild hepatic impairment (Child Pugh A): No adjustment recommended.

Moderate hepatic impairment (Child Pugh B): Do exceed 7.5 mg daily.

Severe hepatic impairment (Child Pugh C): Not recommended.

Dose Adjustments

Do not exceed 7.5 mg daily when coadministered with potent CYP450 3A4 inhibitors (e.g., ketoconazole, itraconazole, miconazole, nefazodone ritonavir).

Other Comments

Administration advice:

-This drug may be taken with or without food.

-The tablet should be swallowed whole with water and not chewed, divided, or crushed.

What is the dose of Darifenacin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Darifenacin available?

Darifenacin is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Darifenacin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: January 19, 2018 | Last Modified: January 19, 2018

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