By Medically reviewed by hellodoktor

Generic Name: Daraprim Brand Name(s): Generics only. No brands available.


What is Daraprim® (pyrimethamine) used for?

Daraprim® is commonly used for treating or preventing malaria and treating toxoplasmosis when used with other medicines (e.g., folinic acid).

Daraprim® is an antiparasitic. It works by killing the parasites or preventing their growth.

How should I take Daraprim® (pyrimethamine)?

Daraprim® may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Your doctor may also prescribe another medicine called folinic acid (leucovorin calcium) to take along with Daraprim®.

Continue using Daraprim® for the full course of treatment even if you feel better in a few days.

How do I store Daraprim® (pyrimethamine)?

Daraprim® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Daraprim® in the bathroom or the freezer. There may be different brands of Daraprim® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Daraprim® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Daraprim® (pyrimethamine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Daraprim® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have depression, seizures, kidney or liver problems, bone marrow problems, stomach or bowel problems (e.g., malabsorption syndrome), phenylketonuria, or alcoholism.

It is important to use Daraprim® for the full course of treatment. Failure to do so may decrease the effectiveness of Daraprim® and may increase the risk that the organisms will no longer be sensitive to Daraprim® and will not be able to be treated by this or certain other antibiotics in the future.

Daraprim® may raise the risk of cancer. Discuss any questions or concerns with your doctor.

Keep away from children. Accidental exposure may cause death. If a child takes this drug by accident, get medical help right away.

Lab tests may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Daraprim® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Daraprim®. Daraprim® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Daraprim® (pyrimethamine)?

Check with your doctor if any of these most common side effects persist or become bothersome:

  • Loss of appetite
  • Nausea
  • Vomiting

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Blood in the urine
  • Irregular heartbeat
  • Pale skin
  • Red spots on the skin
  • Red, swollen, blistered, or peeling skin
  • Severe or persistent vomiting
  • Sore throat or fever
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Daraprim® (pyrimethamine)?

Daraprim® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Phenytoin because side effects of Daraprim® may be increased.
  • Methotrexate, proguanil, quinine, sulfonamides (e.g., sulfamethoxazole), or zidovudine because the risk of bone marrow suppression may be increased.

Does food or alcohol interact with Daraprim® (pyrimethamine)?

Daraprim® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Daraprim® (pyrimethamine)?

Daraprim® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Daraprim® (pyrimethamine).

What is the dose of Daraprim® (pyrimethamine) for an adult?

For Treatment of Toxoplasmosis:

The adult starting dose is 50 to 75 mg of the drug daily, together with 1 to 4 g daily of a sulfonamide of the sulfapyrimidine type, e.g. sulfadoxine.

This dosage is ordinarily continued for 1 to 3 weeks, depending on the response of the patient and tolerance to therapy.

The dosage may then be reduced to about one half that previously given for each drug and continued for an additional 4 to 5 weeks.

For Treatment of Acute Malaria:

Daraprim® is not recommended alone in the treatment of acute malaria. Fast-acting schizonticides, such as chloroquine or quinine are indicated for treatment of acute malaria.

However, Daraprim® at a dosage of 25 mg daily for 2 days with a sulfonamide will initiate transmission control and suppression of non-falciparum malaria.

Daraprim® is only recommended for patients infected in areas where susceptible plasmodia exist.

Should circumstances arise wherein Daraprim® must be used alone in semi-immune persons, the adult dosage for acute malaria is 50 mg for 2 days; children 4 through 10 years old may be given 25 mg daily for 2 days.

In any event, clinical cure should be followed by the once-weekly regimen described below for chemoprophylaxis.

Regimens which include suppression should be extended through any characteristic periods of early recrudescence and late relapse i.e., for at least 10 weeks in each case.

For Chemoprophylaxis of Malaria:

Adults and pediatric patients over 10 years – 25 mg (1 tablet) once weekly.

What is the dose of Daraprim® (pyrimethamine) for a child?

For Treatment of Toxoplasmosis:

The pediatric dosage is 1 mg/kg/day divided into 2 equal daily doses; after 2 to 4 days this dose may be reduced to one half and continued for approximately 1 month.

The usual pediatric sulfonamide dosage is used in conjunction with Daraprim®.

For Chemoprophylaxis of Malaria:

Pediatric patients over 10 years – 25 mg (1 tablet) once weekly.

Children 4 through 10 years – 12.5 mg (1/2 tablet) once weekly.

Infants and children under 4 years – 6.25 mg (1/4 tablet) once weekly.

How is Daraprim® (pyrimethamine) available?

Daraprim® is available in the following dosage forms and strengths:

  • Tablet: pyrimethamine 25mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Daraprim®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: July 26, 2017 | Last Modified: September 13, 2019

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