Dantrolene Natri

By Medically reviewed by hellodoktor

Generic Name: Dantrolene Natri Brand Name(s): Dantrolene Natri and Dantrolene Natri.

Uses

What is dantrolene natri used for?

Dantrolene natri is a muscle relaxant. It works by restoring a normal level of calcium in the muscles, which helps to prevent or reduce severe high body temperature.

Dantrolene natri is commonly used for treating episodes of severe high body temperature (malignant hyperthermia).

It is also used to prevent or reduce the risk of malignant hyperthermia in certain patients before or after surgery or anesthesia. It may also be used for other conditions, ask your doctor for more information.

How should I take dantrolene natri?

Dantrolene natri is usually administered as an injection at your doctor’s office, hospital, or clinic.

If you are using dantrolene natri at home, carefully follow the injection procedures taught to you by your health care provider.

If dantrolene natri contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.

Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.

Ask your health care provider any questions you may have about how to use dantrolene.

How do I store dantrolene natri?

Dantrolene natri is usually handled and stored by a health care provider. If you are using dantrolene natri at home, store dantrolene natri as directed by your pharmacist or health care provider. Keep dantrolene natri out of the reach of children and away from pets.

Precautions & warnings

What should I know before using dantrolene natri?

Before using dantrolene natri, tell your doctor if you are allergic to any ingredient in dantrolene.

Dantrolene natri may cause dizziness, drowsiness, or light-headedness. It may also cause muscle weakness (e.g., decrease in grip strength; weak leg muscles, especially walking down stairs). These symptoms may last for up to 48 hours. Do not drive, operate machinery, or do anything else that could be dangerous during this time.

Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (e.g., sleep aids, muscle relaxers) while you are using dantrolene; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

You may need help with standing and walking until your strength has come back to normal.

Do not use more than the recommended dose without checking with your doctor.

Tell your doctor or dentist that you take dantrolene natri before you receive any medical or dental care, emergency care, or surgery.

To reduce the risk of choking, be sure to chew food thoroughly and swallow small amounts of food on days when dantrolene natri is administered.

Serious and sometimes fatal liver problems have occurred with the oral form of dantrolene. This has occurred most often between the 3rd and 12th month of treatment. The risk may be greater when the medicine is used in higher doses, even for a short period of time. It may also be greater in women, people older than 35 years old, and people who use other medicines at the same time. Discuss any questions or concerns with your doctor.

Dantrolene natri may cause tissue damage if it leaks from the vein. Tell your health care provider if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the medicine is going into your body.

Lab tests, including liver function tests, may be performed while you use dantrolene. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using dantrolene natri during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking dantrolene natri. Dantrolene natri is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from dantrolene natri?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Decreased grip strength
  • Dizziness
  • Drowsiness
  • Flushing
  • Headache
  • Nausea
  • Light-headedness
  • Tiredness
  • Voice changes
  • Weakness (e.g., muscle weakness)

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Blood vessel inflammation
  • Chest pain
  • Choking
  • Difficulty swallowing
  • Shallow breathing
  • Shortness of breath
  • Symptoms of liver problems (e.g., yellowing of the skin or eyes, dark urine, pale stools, nausea, stomach pain, loss of appetite, unusual tiredness)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with dantrolene natri?

Dantrolene natri may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with dantrolene natri?

Dantrolene natri may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with dantrolene natri?

Dantrolene natri may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using dantrolene natri.

What is the dose of dantrolene natri for an adult?

Malignant hyperthermia (Per MHAUS)

The recommended dose is 2.5 mg/kg rapid IV bolus, repeat PRN.

Sometimes >10 mg/kg (cumulative dose) is necessary (up to 30 mg/kg).

Maintenance dose is 1 mg/kg IV q4-6hr OR 0.25 mg/kg/hr IV infusion.

Continue at least for 36 hr.

Malignant Hyperthermia, Prevention

1-3 days before surgery: The recommended dose is 4-8 mg/kg/day PO divided q6hr.

75 minutes before anesthesia: The recommended dose is 2.5 mg/kg IV once over 60 minutes; administer additional doses PRN.

Spasticity

  • The recommended dose is 25 mg PO qDay for 7 days.
  • The recommended dose is 25 mg PO q8hr for 7 days.
  • The recommended dose is 50 mg PO q8hr for 7 days.

The recommended dose is 100 mg PO q8hr, not to exceed 100 mg PO q6hr.

Discontinued if no benefits within 6-7 weeks.

Neuroleptic Malignant Syndrome (Off-label)

The recommended dose is 25 mg/day IV; gradually increase to 150 mg/day.

Succinylcholine-induced Fasciculations and Post-op Muscle Pain (Off-label)

<45 kg: The recommended dose is 100 mg PO 2 hr pre-op.

≥45 kg: The recommended dose is 150 mg PO 2 hr pre-op.

Monitor: LFTs, bilirubin

What is the dose of dantrolene natri for a child?

Malignant Hyperthermia (Per MHAUS)

The recommended dose is 2.5 mg/kg rapid IV bolus, repeat PRN.

Sometimes >10 mg/kg (cumulative dose) is necessary (up to 30 mg/kg).

Maintenance dose is 1 mg/kg IV q4-6hr OR 0.25 mg/kg/hr IV infusion.

Continue at least for 36 hr.

Malignant Hyperthermia, Prevention

1-3 days before surgery: The recommended dose is 4-8 mg/kg/day PO divided q6hr.

75 minutes before anesthesia: The recommended dose is 2.5 mg/kg IV once over 60 minutes; administer additional doses PRN.

Spasticity

Monitor: LFTs, bilirubin

≥5 Years

  • The recommended dose is 0.5 mg/kg PO qDay for 7 days.
  • The recommended dose is 0.5 mg/kg PO q8hr for 7 days.
  • The recommended dose is 1 mg/kg PO q8hr for 7 days.
  • The recommended dose is 2 mg/kg PO q8hr, not to exceed 100 mg PO q6hr.

<5 Year

  • Initial dose is 1 mg/kg/day PO divided q12hr.
  • Maximum maintenance dose is 12 mg/kg/day PO divided q6hr.
  • Not to exceed 3 mg/kg PO q6-12hr OR 400 mg/24 hr PO.

How is dantrolene natri available?

Dantrolene natri is available in the following dosage forms and strengths:

  • Dantrolene natri capsules 25mg
  • Dantrolene natri capsules 50mg
  • Dantrolene natri capsules 100mg
  • Dantrolene natri powder for injection 20mg/vial
  • Dantrolene natri powder for injection 250mg/vial

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of dantrolene, contact your doctor or health care provider immediately.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 5, 2017 | Last Modified: September 12, 2019

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