Cytomegalovirus Immune Globulin

By

Generic Name: Cytomegalovirus Immune Globulin Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Cytomegalovirus Immune Globulin used for?

Cytomegalovirus Immune Globulin is used to prevent a certain serious viral infection (cytomegalovirus-CMV) in persons having an organ transplant (kidney, heart, liver, lung, pancreas). During the transplant process, the body’s defense system (immune system) is weakened to prevent the body from attacking (rejecting) the new organ. A weakened immune system increases the risk of a serious, possibly fatal infection with CMV. This medication is made from healthy human blood that has a high level of certain defensive substances (antibodies) that help fight CMV. This medication is often used with the antiviral medication ganciclovir.

How should I take Cytomegalovirus Immune Globulin?

This medication is given by slow infusion into a vein as directed by your doctor.

Your health care professional will start the medication slowly while monitoring you closely. If you have few or no side effects, the medication will be given faster. Tell your health care professional right away if you experience any side effects such as flushing, chills, muscle cramps, back/joint pain, fever, nausea, vomiting, or shortness of breath. The infusion may need to be stopped or given more slowly.

The first dose is usually given within 3 days of the transplant, followed by more doses every 2 to 4 weeks or as directed by your doctor. The dosage and frequency depends on your medical condition, weight, and response to treatment.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Use this medication regularly in order to get the most benefit from it. Keep all your medical/lab appointments.

How do I store Cytomegalovirus Immune Globulin?

Cytomegalovirus Immune Globulin is best stored at 2oC to 8oC away from direct light and moisture. To prevent drug damage, you should not store Cytomegalovirus Immune Globulin in the bathroom or the freezer.

There may be different brands of Cytomegalovirus Immune Globulin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Cytomegalovirus Immune Globulin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Cytomegalovirus Immune Globulin?

Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or to other immunoglobulin products (such as IgG); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain immune system problems (immunoglobulin A deficiency, monoclonal gammopathies), diabetes, high blood pressure, high blood fats (triglycerides), migraines, current blood infection (sepsis), kidney disease, severe loss of body fluids (dehydration).

Tell your doctor of any recent or planned immunizations/vaccinations. This medication may prevent a good response to certain live viral vaccines (such as measles, mumps, rubella, varicella). If you have recently received any of these vaccines, your doctor may have you tested for a response or have you vaccinated again later. If you plan on getting any of these vaccines, your doctor will instruct you about the best time to receive them so you get a good response.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Cytomegalovirus Immune Globulin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Cytomegalovirus Immune Globulin. Cytomegalovirus Immune Globulin is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Cytomegalovirus Immune Globulin?

Flushing, chills, muscle cramps, back/joint pain, fever, nausea/vomiting may occur. Tell your doctor or health care professional right away if any of these effects occur, persist, or worsen. Pain, redness, and swelling at the injection site may also occur. If these effects continue or become bothersome, tell your doctor.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor if you experience any of these unlikely but serious side effects: easy bleeding/bruising, fast/irregular heartbeat, unusual tiredness, signs of kidney problems (such as change in the amount of urine, pink/bloody/frothy urine), sudden weight gain.

Rarely, this product may contain substances that could cause infections because it is made from human blood. Discuss the risks and benefits with your doctor. Tell your doctor right away if you develop any signs of infection such as persistent sore throat/fever, yellowing eyes/skin, or dark urine.

Treatment with this medication may rarely cause an inflammation of the brain (aseptic meningitis syndrome) several hours to 2 days after your treatment. Get medical help right away if you develop severe headache, stiff neck, drowsiness, high fever, sensitivity to light, eye pain, or severe nausea/vomiting.

Lung problems may occur 1 to 6 hours after your treatment. You will be monitored closely for any lung problems after your treatment.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Cytomegalovirus Immune Globulin?

Some products that may interact with this drug include: drugs that may harm the kidney (e.g., aminoglycosides such as gentamicin), “water pills” (diuretics such as furosemide).

Cytomegalovirus Immune Globulin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Cytomegalovirus Immune Globulin?

Cytomegalovirus Immune Globulin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Cytomegalovirus Immune Globulin?

Cytomegalovirus Immune Globulin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Cytomegalovirus Immune Globulin.

What is the dose of Cytomegalovirus Immune Globulin for an adult?

Usual Adult Dose for CMV Prophylaxis

Kidney transplant:

Within 72 hours of transplant: 150 mg/kg

2 to 8 weeks post transplant: 100 mg/kg

12 to 16 weeks post transplant: 50 mg/kg

Liver, pancreas, lung, heart transplant:

Within 72 hours of transplant: 150 mg/kg

2 to 8 weeks post transplant: 150 mg/kg

12 to 16 weeks post transplant: 100 mg/kg

Administer IV at 15 mg/kg/hour. If no adverse reactions occur after 30 minutes, the rate may be increased to 30 mg/kg/hour for 15 minutes before increasing to a maximum rate of 60 mg/kg/hour. Maximum volume not to exceed 75 mL/hr.

The maximum recommended total dosage per infusion is 150 mg/kg.

Renal Dose Adjustments

Cytomegalovirus immune globulin (CMV-IGIV) should be used with caution in patients with renal impairment or patients at risk for development of renal impairment. Do not exceed an infusion rate of 60 mg/kg/hour (maximum volume 75 mL/hour).

If renal function deteriorates, discontinuation of CMV-IGIV should be considered.

Most cases of renal insufficiency have occurred in patients receiving total doses of 350 mg/kg or greater.

What is the dose of Cytomegalovirus Immune Globulin for a child?

Usual Pediatric Dose for CMV Prophylaxis

Kidney transplant:

Within 72 hours of transplant: 150 mg/kg

2 to 8 weeks post transplant: 100 mg/kg

12 to 16 weeks post transplant: 50 mg/kg

Liver, pancreas, lung, heart transplant:

Within 72 hours of transplant: 150 mg/kg

2 to 8 weeks post transplant: 150 mg/kg

12 to 16 weeks post transplant: 100 mg/kg

Administer IV at 15 mg/kg/hour. If no adverse reactions occur after 30 minutes, the rate may be increased to 30 mg/kg/hour for 15 minutes before increasing to a maximum rate of 60 mg/kg/hour.

The maximum recommended total dosage per infusion is 150 mg/kg

How is Cytomegalovirus Immune Globulin available?

Cytomegalovirus Immune Globulin is available in the following dosage forms and strengths:

  • Intravenous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Cytomegalovirus Immune Globulin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: September 2, 2018 | Last Modified: September 2, 2018

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.