Generic Name: Cyproheptadine Brand Name(s): Cyproheptadine.

Uses

What is Cyproheptadine used for?

Cyproheptadine is commonly used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. This medication also blocks another natural substance in your body (serotonin).

This medication should not be used in newborn or premature infants.

How should I take Cyproheptadine?

Take this medication by mouth with or without food as directed by your doctor, usually 2 to 3 times a day. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight and body size. Do not increase your dose or take this medication more often than directed.

Tell your doctor if your condition does not improve or if it worsens.

How do I store Cyproheptadine?

Cyproheptadine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Cyproheptadine in the bathroom or the freezer. There may be different brands of Cyproheptadine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Cyproheptadine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Cyproheptadine?

Before taking cyproheptadine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, emphysema), high pressure in the eye (glaucoma), heart disease, high blood pressure, kidney disease, seizures, stomach/intestine problems (such as ulcers, blockage), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate).

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Liquid products may contain alcohol and/or sugar. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Children may be more sensitive to the side effects of this drug. This drug can often cause excitement in young children instead of drowsiness.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, constipation, confusion, or trouble urinating. Drowsiness, dizziness, and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Cyproheptadine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this Cyproheptadine. This Cyproheptadine is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Cyproheptadine?

Drowsiness, dizziness, blurred vision, constipation, or dry mouth/nose/throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as restlessness, confusion, hallucinations), shaking (tremor), difficulty urinating, fast/irregular heartbeat.

Get medical help right away if you have any very serious side effects, including: seizures.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Cyproheptadine?

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

This medication may interfere with certain laboratory tests (including allergy skin testing, metyrapone test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Cyproheptadine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Cyproheptadine?

Cyproheptadine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Cyproheptadine?

Cyproheptadine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Cyproheptadine.

What is the dose of Cyproheptadine for an adult?

Usual Adult Dose for Allergic Reaction

Initial dose: 4 mg orally three times a day

Maintenance dose: 12 to 16 mg/day, occasionally up to 32 mg/day but not to exceed 0.5 mg/kg/day

Usual Adult Dose for Allergic Rhinitis

Initial dose: 4 mg orally three times a day

Maintenance dose: 12 to 16 mg/day, occasionally up to 32 mg/day but not to exceed 0.5 mg/kg/day

Usual Adult Dose for Pruritus

Initial dose: 4 mg orally three times a day

Maintenance dose: 12 to 16 mg/day, occasionally up to 32 mg/day but not to exceed 0.5 mg/kg/day

Usual Adult Dose for Urticaria

Initial dose: 4 mg orally three times a day

Maintenance dose: 12 to 16 mg/day, occasionally up to 32 mg/day but not to exceed 0.5 mg/kg/day

Usual Adult Dose for Anorexia Nervosa

Initial dose: 2 mg orally four times a day

Maintenance dose: may increase gradually over 3 weeks to 8 mg orally four times a day

Usual Adult Dose for Cushing’s Syndrome

Initial dose: 2 mg orally four times a day

Maintenance dose: may increase gradually over 3 weeks to 8 mg orally four times a day

Usual Adult Dose for Cluster Headache

4 mg orally four times a day

Usual Adult Dose for Migraine

4 to 8 mg orally three times a day

Liver Dose Adjustments

The pharmacokinetics of cyproheptadine in patients with liver disease have not been studied. Since cyproheptadine is primarily metabolized by the liver, caution is advised when it is administered to patients with impaired hepatic function.

What is the dose of Cyproheptadine for a child?

Usual Pediatric Dose for Allergic Reaction

0.25 mg/kg/day or 8 mg/m2 body surface area in 2 to 3 divided doses, or by age as follows:

2 to 6 years: 2 mg orally two to three times a day, not to exceed 12 mg/day

7 to 14 years: 4 mg orally two to three times a day, not to exceed 16 mg/day

Usual Pediatric Dose for Allergic Rhinitis

0.25 mg/kg/day or 8 mg/m2 body surface area in 2 to 3 divided doses, or by age as follows:

2 to 6 years: 2 mg orally two to three times a day, not to exceed 12 mg/day

7 to 14 years: 4 mg orally two to three times a day, not to exceed 16 mg/day

Usual Pediatric Dose for Pruritus

0.25 mg/kg/day or 8 mg/m2 body surface area in 2 to 3 divided doses, or by age as follows:

2 to 6 years: 2 mg orally two to three times a day, not to exceed 12 mg/day

7 to 14 years: 4 mg orally two to three times a day, not to exceed 16 mg/day

Usual Pediatric Dose for Urticaria

0.25 mg/kg/day or 8 mg/m2 body surface area in 2 to 3 divided doses, or by age as follows:

2 to 6 years: 2 mg orally two to three times a day, not to exceed 12 mg/day

7 to 14 years: 4 mg orally two to three times a day, not to exceed 16 mg/day

Usual Pediatric Dose for Anorexia

> 13 years: 2 mg orally 4 times a day. May be increased gradually over a 3 week period to 8 mg 4 times a day. Maximum dose is 32 mg/day.

Usual Pediatric Dose for Migraine

4 mg orally two to three times a day

Precautions

Cyproheptadine should not be used in newborn or premature infants.

How is Cyproheptadine available?

Cyproheptadine is available in the following dosage forms and strengths:

  • Tablet
  • Syrup

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Cyproheptadine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: January 18, 2018 | Last Modified: January 18, 2018

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