Generic Name: Cymbalta Brand Name(s): Generics only. No brands available.


What is Cymbalta® (duloxetine) used for?

Cymbalta® is commonly used to treat these following health conditions, such as:

  • Major depressive disorder in adults
  • Anxiety disorder in adults and children who are at least 7 years old
  • Fibromyalgia (a chronic pain disorder)
  • Chronic muscle or joint pain (such as low back pain and osteoarthritis pain)
  • Pain caused by nerve damage in adults with diabetes (diabetic neuropathy)

Cymbalta® may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Cymbalta® (duloxetine)?

Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Cymbalta® by mouth with a full glass of water, do not chew or break it, swallow the whole capsule.

Ask your health care provider any questions you may have about how to use this medication.

How do I store Cymbalta® (duloxetine)?

Cymbalta® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Cymbalta® in the bathroom or the freezer. There may be different brands of Cymbalta® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Cymbalta® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Cymbalta® (duloxetine)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Cymbalta® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Cymbalta® (duloxetine)?

Cymbalta® may cause following side effects, such as:

  • Nausea
  • Dry mouth
  • Constipation
  • Loss of appetite
  • Tiredness
  • Drowsiness
  • Increased sweating
  • Dizziness or lightheadedness

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Cymbalta® (duloxetine)?

Cymbalta® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some products that may interact with this drug include:

  • MAOIs, such as isocarboxazid (Marplan), linezolid (Zyvox), and phenelzine (Nardil)
  • Blood thinners, such as warfarin (Coumadin, Jantoven)
  • Other antidepressants, including amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), and certain selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem)
  • Over-the-counter pain medications, including aspirin, ibuprofen (Advil, Motrin), and naproxen (Aleve)
  • Drugs used to treat mental illness, including lithium (Eskalith, Lithobid)
  • Diuretics (water pills)
  • Heart and blood pressure medications, including amiodarone (Cordarone) and flecainide (Tambocor)
  • Prescription pain medications, including fentanyl (Abstral, Actiq, Fentora, Onsolis)
  • Medications used to treat heartburn, such as cimetidine (Tagamet), lansoprazole (Prevacid), and omeprazole (Prilosec)
  • Some antibiotics, including ciprofloxacin (Cipro) and enoxacin (Penetrex)
  • Medications used to treat migraines, including such as almotriptan (Axert), eletriptan (Relpax), and frovatriptan (Frova)
  • John’s wort

Does food or alcohol interact with Cymbalta® (duloxetine)?

Cymbalta® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Cymbalta® (duloxetine)?

Cymbalta® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Liver or kidney disease
  • Seizures or epilepsy
  • A bleeding or blood clotting disorder
  • High blood pressure
  • Narrow-angle glaucoma
  • Bipolar disorder (manic depression)
  • A history of drug abuse or suicidal thoughts


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Cymbalta® (duloxetine) for an adult?

A typical dose for depression is 40 to 60 milligrams (mg) a day.

A typical dose for diabetic nerve pain, anxiety, fibromyalgia, or muscle/bone pain is 60 mg a day.

What is the dose of Cymbalta® (duloxetine) for a child?

Children 7-17 years:

The recommended dose is 30 mg PO qDay initially; after 2 weeks, may consider increasing dose to 60 mg/day.

The dosage has not been established in pediatric patients (under 7 years old). It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Cymbalta® (duloxetine) available?

Cymbalta® is available in the following dosage forms and strengths:

  • Cymbalta® Delayed Release Capsule 20mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Cymbalta®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: June 2, 2017 | Last Modified: June 2, 2017

You might also like