Cyclopentolate

By Medically reviewed by hellodoktor

Generic Name: Cyclopentolate Brand Name(s): Generics only. No brands available.

Uses

What is Cyclopentolate used for?

Cyclopentolate is commonly used before eye examinations (e.g., refraction exams). It belongs to a class of drugs known as anticholinergics. Cyclopentolate works by temporarily widening (dilating) the pupil of the eye and relaxing the muscles of the eye.

How should I take Cyclopentolate?

This medication is usually applied in the eye 40 to 50 minutes before the procedure or as directed by your doctor. The dose may need to be repeated in 5 to 10 minutes. This medication is for use in the eye only. Do not take by mouth or inject.

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. If you are wearing contact lenses, remove them before using eye drops. Ask your doctor when you can start wearing them again. If you are using another kind of eye medication (e.g., drops or ointments), ask your doctor when you should start using them again.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place 1 drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure for 2 to 3 minutes. This will prevent the medication from draining away from the eye and reduce side effects. Try not to blink and do not rub your eye. Repeat these steps if your dose is for more than 1 drop or for your other eye if so directed.

Do not rinse the dropper. Replace cap after use.

If you are using this medicine in a child’s eye(s), do not get any medicine in the child’s mouth. Wash your hands and your child’s hands after use to remove any medicine from them.

This medication may temporarily change digestion in infants. Do not feed an infant for 4 hours after the infant’s eye exam.

This medication starts to work in minutes, and its effect usually lasts 24 hours or sometimes longer. Tell your doctor if you continue to have blurred vision, sensitivity to light, or dilated pupils several days after your exam.

How do I store Cyclopentolate?

Store at 8° to 25°C (46° to 77°F). If you need to store this medicine at home, talk with your doctor, nurse, or pharmacist about how to store it.

Precautions & warnings

What should I know before using Cyclopentolate?

Before using cyclopentolate, tell your doctor or pharmacist if you are allergic to it; or to belladonna alkaloids (e.g., atropine); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), Down’s syndrome, brain damage or spastic paralysis (in children), heart disease.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication may make your eyes more sensitive to light. Protect your eyes in bright light. Use dark sunglasses when outdoors.

Caution is advised when using this drug in infants or small children because they may be more sensitive to the effects of the drug, especially mental/mood changes. If using this medication in an infant, watch the infant closely for 30 minutes after the medication is applied.

Caution is advised when this drug is used in the elderly since this group may be more sensitive to side effects of this drug, especially increased pressure in the eye.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Cyclopentolate during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this Cyclopentolate. This Cyclopentolate is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Cyclopentolate?

Burning/stinging/redness of the eye, eye irritation, or temporary blurred vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: dizziness, fainting, mental/mood changes (e.g., confusion, hallucinations, restlessness, strange behavior).

Get medical help right away if you have any very serious side effects, including: eye pain/swelling, vision changes (such as seeing rainbows around lights at night), slow/shallow breathing, fast/irregular heartbeat, seizures.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Cyclopentolate?

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: eye medications for glaucoma/increased pressure in the eye (e.g., dorzolamide, pilocarpine), certain antiarrhythmic drugs (e.g., quinidine), antihistamines (e.g., diphenhydramine, meclizine), antispasmodics (e.g., dicyclomine), certain drugs for Parkinson’s disease (e.g., anticholinergics such as benztropine, trihexyphenidyl), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), tricyclic antidepressants (e.g., amitriptyline).

Cyclopentolate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Cyclopentolate?

Cyclopentolate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Cyclopentolate?

Cyclopentolate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Cyclopentolate.

What is the dose of Cyclopentolate for an adult?

Usual Adult Dose for Refraction

Instill 1 to 2 drops in the eye(s) once; may repeat in 5 to 10 minutes if needed

Comments: The 0.5%, 1%, or 2% solution may be used.

Uses: To produce mydriasis and cycloplegia

Usual Adult Dose for Pupillary Dilation

Instill 1 to 2 drops in the eye(s) once; may repeat in 5 to 10 minutes if needed

Comments: The 0.5%, 1%, or 2% solution may be used.

Uses: To produce mydriasis and cycloplegia

Other Comments

Administration advice:

-For topical ophthalmic use only; not for injection.

-Feeding should be withheld for 4 hours after examination in infants.

-Wash hands and hands of child after use.

-Patients with heavily pigmented irides may require higher strength.

-Complete recovery usually occurs in 24 hours; complete recovery from mydriasis may require several days in some patients.

Patient advice:

-Avoid touching tip of dropper to any surface as this may cause contamination.

-Transient burning sensation may occur upon instillation.

-Avoid driving or engaging in hazardous activities while pupils are dilated.

-Protect eyes from bright illumination as sensitivity to light can occur.

What is the dose of Cyclopentolate for a child?

Usual Pediatric Dose for Refraction

Infants: Instill 1 drop of 0.5% solution into the eye(s) once

Comments:

-To minimize absorption, pressure should be applied over the nasolacrimal sac for 2 to 3 minutes.

-The infant should be observed for at least 30 minutes after instillation.

Children: Instill 1 to 2 drops in the eye(s) once; may repeat in 5 to 10 minutes if needed using the 0.5% or 1% solution

Comments: Initial dose in children may be given using the 0.5%, 1%, or 2% solution.

Uses: To produce mydriasis and cycloplegia

Usual Pediatric Dose for Pupillary Dilation

Infants: Instill 1 drop of 0.5% solution into the eye(s) once

Comments:

-To minimize absorption, pressure should be applied over the nasolacrimal sac for 2 to 3 minutes.

-The infant should be observed for at least 30 minutes after instillation.

Children: Instill 1 to 2 drops in the eye(s) once; may repeat in 5 to 10 minutes if needed using the 0.5% or 1% solution

Comments: Initial dose in children may be given using the 0.5%, 1%, or 2% solution.

Uses: To produce mydriasis and cycloplegia

How is Cyclopentolate available?

Cyclopentolate is available in the following dosage forms and strengths:

  • Eye Drops

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Cyclopentolate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 17, 2018 | Last Modified: September 12, 2019

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