Generic Name: Crestor Brand Name(s): Generics only. No brands available.

Uses

What is Crestor® (rosuvastatin) used for?

Crestor® belongs to a group of drugs called HMG CoA reductase inhibitors, or “statins.”

Crestor® is used in adults and children who are at least 8 years old to lower cholesterol and triglycerides (types of fat) in the blood and to slow the build-up of plaque (fatty deposits) in your blood vessels.

Crestor® is also used to lower the risk of stroke, heart attack, and other heart complications in certain people with diabetes, coronary heart disease, or other risk factors.

Crestor® is also used to treat hereditary forms of high cholesterol, including the heterozygous type (inherited from one parent) and the homozygous type (inherited from both parents). For the heterozygous type, Crestor® can be used in children who are at least 8 years old. For the homozygous type, Crestor® can be used in children as young as 7 years old.

How should I take Crestor® (rosuvastatin)?

Take Crestor® exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Crestor® is usually taken once a day, with or without food. Take the medicine at the same time each day.

While using this medicine, you may need frequent blood tests.

Keep using this medicine as directed, even if you feel well. High cholesterol usually has no symptoms. You may need to take Crestor® on a long-term basis.

You should not stop using Crestor® unless your doctor tells you to.

Crestor® is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor’s instructions very closely.

How do I store Crestor® (rosuvastatin)?

Crestor® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Crestor® in the bathroom or the freezer. There may be different brands of Crestor® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Crestor® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Crestor® (rosuvastatin)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Crestor® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You may need to stop using Crestor® for a short time if you have:

  • Uncontrolled seizures
  • An electrolyte imbalance (such as high or low potassium levels in your blood)
  • Severely low blood pressure
  • A severe infection or illness
  • Dehydration
  • Surgery or a medical emergency

You should not take Crestor® if you have liver disease.

Rosuvastatin can harm an unborn baby or cause birth defects. Do not take this medicine if you are pregnant. Stop taking Crestor® and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking Crestor®.

Rosuvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking this medicine.

Crestor® can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

People of Asian descent may absorb rosuvastatin at a higher rate than other people. Make sure your doctor knows if you are Asian. You may need a lower than normal starting dose.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Crestor® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Crestor®. Crestor® is pregnancy risk category X, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Crestor® (rosuvastatin)?

Common side effects may include:

  • Liver symptoms (stomach pain, dark urine, jaundice)
  • Unusual weakness or tired feeling
  • Headache
  • Muscle aches
  • Nausea
  • Upset stomach

Also call your doctor at once if you have:

  • Confusion
  • Memory problems
  • Liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Signs of a kidney problem – little or no urinating; painful or difficult urination; swelling in your feet or ankles
  • Feeling tired or short of breath

Get emergency medical help if you have any signs of an allergic reaction to Crestor®: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, Crestor® can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Crestor® (rosuvastatin)?

Crestor® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Colchicine
  • Cyclosporine
  • Another “statin” medicine – atorvastatin, lovastatin, simvastatin, Lipitor, Pravachol, Zocor, Vytorin, and others
  • Antifungal medicine – fluconazole, itraconazole, ketoconazole
  • Antiviral medicine to treat HIV or hepatitis C – atazanavir, fosamprenavir, lopinavir, ritonavir, simeprevir, tipranavir, and others
  • A blood thinner – warfarin, Coumadin, Jantoven
  • Other cholesterol medications – fenofibrate, gemfibrozil
  • Medicines that contain niacin or nicotinic acid – vitamin B3, Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others

Does food or alcohol interact with Crestor® (rosuvastatin)?

Crestor® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Crestor® (rosuvastatin)?

Crestor® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • A history of liver disease
  • A history of kidney disease
  • Diabetes
  • A thyroid disorder

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Crestor® (rosuvastatin).

What is the dose of Crestor® (rosuvastatin) for an adult?

Usual Adult Dose for Hyperlipoproteinemia:

Initial dose: 5 mg to 10 mg once a day with or without food.

Maintenance dose: 5 mg to 40 mg once a day with or without food.

Usual Adult Dose for Hyperlipoproteinemia Type IIa (Elevated LDL):

Initial dose: 5 mg to 10 mg once a day with or without food.

Maintenance dose: 5 mg to 40 mg once a day with or without food.

Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL):

Initial dose: 5 mg to 10 mg once a day with or without food.

Maintenance dose: 5 mg to 40 mg once a day with or without food.

Usual Adult Dose for Hyperlipoproteinemia Type IV (Elevated VLDL):

Initial dose: 5 mg to 10 mg once a day with or without food.

Maintenance dose: 5 mg to 40 mg once a day with or without food.

Usual Adult Dose for Atherosclerosis:

Initial dose: 5 mg to 10 mg once a day with or without food.

Maintenance dose: 5 mg to 40 mg once a day with or without food.

Usual Adult Dose for Homozygous Familial Hypercholesterolemia:

Initial dose: 20 mg once a day with or without food.

Maintenance dose: 20 mg to 40 mg once a day with or without food.

Usual Adult Dose for Prevention of Cardiovascular Disease:

Initial dose: 5 mg to 10 mg once a day with or without food.

Maintenance dose: 5 mg to 40 mg once a day with or without food.

Usual Geriatric Dose for Hyperlipidemia:

Initial dose: 5 mg once a day with or without food.

Maintenance dose: 5 mg to 20 mg once a day with or without food.

What is the dose of Crestor® (rosuvastatin) for a child?

Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia:

Pediatric patients 10 to 17 years of age:

  • Usual dose range: 5 to 20 mg orally once a day with or without food. Doses should be individualized according to the recommended goal of therapy.
  • Adjustments should be made at intervals of 4 weeks or more.
  • Maximum dose: 20 mg orally once a day.

How is Crestor® (rosuvastatin) available?

Crestor® (rosuvastatin) is available in the following dosage forms and strengths:

  • Tablet, film coated: rosuvastatin calcium 5mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Crestor®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: July 19, 2017 | Last Modified: July 19, 2017