By Medically reviewed by hellodoktor

Generic Name: Combivent Brand Name(s): Generics only. No brands available.


What is Combivent® (albuterol and ipratropium) used for?

Combivent® is commonly used for preventing bronchospasm associated with obstructive pulmonary disease (COPD) in patients who require more than a single bronchodilator.

How should I take Combivent® (albuterol and ipratropium)?

To use the Combivent® inhaler:

  • Insert metal canister into clear end of mouthpiece. Make sure the canister is fully and firmly inserted into the mouthpiece.
  • Remove orange protective dust cap. If the cap is not on the mouthpiece, make sure there is nothing in the mouthpiece before use. For best results, the canister should be at room temperature before use.
  • Shake and Test Spray. Perform this step before using for the first time, and whenever the aerosol has not been used for more than 24 hours.
  • Shake the canister vigorously for at least 10 seconds. Vigorous shaking for at least 10 seconds before each spray is very important for proper performance.
  • Breathe out (exhale) deeply through your mouth. Holding the canister upright, between your thumb and finger(s), put the mouthpiece in your mouth and close your lips. Keep your eyes closed so that no medicine will be sprayed into your eyes. Combivent® can cause blurry vision, narrow-angle glaucoma or worsening of this condition or eye pain if the medicine is sprayed into your eyes.
  • Breathe in slowly through your mouth and at the same time spray the medicine into your mouth. To spray the medicine, firmly press once on the canister against the mouthpiece. Keep breathing in deeply.
  • Hold your breath for 10 seconds, remove the mouthpiece from your mouth and breathe out slowly.
  • If you use more than one inhalation at a time, wait at least 2 minutes before using the second inhalation, shake the inhaler vigorously for at least 10 seconds again and repeat dose.
  • Replace the orange protective dust cap after use.
  • Keep track of the number of sprays used and discard after 200 sprays. Even though the canister is not empty, you cannot be sure of the amount of medicine in each spray after 200 sprays.
  • Keep your inhaler clean and dry, and store it with the cap on the mouthpiece. Clean your inhaler once a week by removing the canister and placing the mouthpiece under warm running water for at least 30 seconds. Allow the parts to dry before putting the inhaler back together.

How do I store Combivent® (albuterol and ipratropium)?

Combivent® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Combivent® in the bathroom or the freezer. There may be different brands of Combivent® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Combivent® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Combivent® (albuterol and ipratropium)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Combivent® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Combivent® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Combivent®. Combivent® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Combivent® (albuterol and ipratropium)?

Common side effects may include:

  • Mild headache
  • Cold symptoms such as stuffy nose, sneezing, cough, or sore throat

Stop using Combivent® and call your doctor at once if you have:

  • Wheezing, choking, or other breathing problems (especially after starting a new canister of this medicine)
  • Chest pain, pounding heartbeats or fluttering in your chest
  • Dangerously high blood pressure (severe headache, anxiety, uneven heartbeats)
  • Swelling of your ankles or feet
  • Eye pain, or seeing halos around lights
  • Painful or difficult urination
  • Low potassium (confusion, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling)

Get emergency medical help if you have any of these signs of an allergic reaction are hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Combivent® (albuterol and ipratropium)?

Combivent® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug, including:

  • Albuterol (Proventil, Ventolin)
  • Ipratropium (Atrovent)
  • Atropine (Atreza, Lomotil, Vi-Atro, Sal-Tropine)

Does food or alcohol interact with Combivent® (albuterol and ipratropium)?

Combivent® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Combivent® (albuterol and ipratropium)?

Combivent® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

To make sure Combivent® is safe for you, tell your doctor about your other medical conditions, especially:

  • Heart disease
  • High blood pressure
  • Coronary artery disease
  • Heart rhythm disorder
  • Seizure disorder such as epilepsy
  • Diabetes
  • Overactive thyroid
  • Glaucoma
  • Enlarged prostate
  • Problems with urination
  • Liver or kidney disease


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Combivent® (albuterol and ipratropium).

What is the dose of Combivent® (albuterol and ipratropium) for an adult?

Acute attacks:

The recommended dose is 1unit dose vial.

In severe cases not relieved by 1unit dose vial: Administration of 2nd unit dose vial, patient should consult a doctor immediately.

Maintenance: The recommended dose is 1unit dose vial tds or qds.

What is the dose of Combivent® (albuterol and ipratropium) for a child?

The dosage has not been established in pediatric patients under 12 years old. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Combivent® (albuterol and ipratropium) available?

Combivent® is available in the following dosage forms and strengths:

  • Combivent® inhalant (unit-dose vial)2.5mL/vial, package of 20 vials

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Combivent®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: June 8, 2017 | Last Modified: September 12, 2019