By Medically reviewed by hellodoktor

Generic Name: Cobanzyme Brand Name(s): Cobanzyme, Cobanzyme and Cobanzyme.


What is cobanzyme (vitamin B12) used for?

Cobanzyme is commonly used for the treatment of:

  • B12-deficiency conditions
  • In the complex therapy for iron and posthemorrhagic anemia
  • Aplastic anemia caused by toxic substances and drugs
  • Liver disease (hepatitis, cirrhosis)
  • Funicular myelosis
  • Polyneuritis, radiculitis, neuralgia, amyotrophic lateral sclerosis
  • Children cerebral palsy, Down syndrome, peripheral nerve injury
  • Skin diseases (psoriasis, photodermatosis, herpetiformis dermatitis, neurodermatitis)
  • Radiation sickness

How should I take cobanzyme (vitamin B12)?

Cobanzyme is used as injections SC, IV, IM, intralumbar, and oral.

Follow all directions on your prescription label.

Do not take this medicine in larger amounts or for longer than recommended.

How do I store cobanzyme (vitamin B12)?

Cobanzyme is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store cobanzyme in the bathroom or the freezer. There may be different brands of cobanzyme that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush cobanzyme down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using cobanzyme (vitamin B12)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of cobanzyme or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from cobanzyme (vitamin B12)?

When using this drug, some side effects may occur:

  • Central nervous system
  • Cardiovascular system (pain in the heart, tachycardia)
  • Allergic reactions (urticaria)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with cobanzyme (vitamin B12)?

Cobanzyme may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Especially if you are taking:

  • Hormonal contraceptives
  • Anticonvulsant drugs
  • Neomycin, aminosalicylic acid, colchicine, cimetidine, ranitidine, drugs potassium
  • Thiamine
  • Chloramphenicol
  • Thromboembolism, erythremia, erythrocytosis

Does food or alcohol interact with cobanzyme (vitamin B12)?

Cobanzyme may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with cobanzyme (vitamin B12)?

Cobanzyme may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using cobanzyme (vitamin B12).

What is the dose of Cobanzyme (vitamin B12) for an adult?

With anemia associated with cobanzyme deficiency, the recommended dose is 100-200 mcg in 2 days.

In anemia with symptoms of funicular myelosis and megalocytic anemia with diseases of the nervous system, the recommended dose is 400-500 micrograms in the first 7 days daily, then 1 time every 5-7 days.

In the period of remission in the absence of events funicular myelosis maintenance dose, the recommended dose is 100 mcg 2 times a month; in the presence of neurological symptoms, the recommended dose is 200-400 mcg 2-4 times a month.

In acute post-hemorrhagic anemia and iron anemia, the recommended dose is 30-100 mcg 2-3 times a week.

In diseases of the central and peripheral nervous system and neurological diseases with a pain syndrome is administered in increasing doses, the recommended dose is 200-500 mcg; with the improvement in the state, the recommended dose is 100 mcg / day. The course of treatment is 2 weeks.

In traumatic lesions of peripheral nervous system, the recommended dose is 200-400 mcg every other day for 40-45 days.

When hepatitis and cirrhosis, the recommended dose is 30-60 mcg / day or 100 mg every other day for 25-40 days.

When funicular myelosis, amyotrophic lateral sclerosis can be introduced into the spinal canal at 15-30 mcg, gradually increasing the dose of 200-250 micrograms.

In radiation sickness, diabetic neuropathy, sprue, the recommended dose is 60-100 mcg daily for 20-30 days.

When deficiency of cobanzyme, the recommended dose is IV or IM for 1 mg 1 time a month; for treatment, the recommended dose is IV or IM for 1 mg daily for 1-2 weeks. The maintenance dose is 1-2 mg IV or IM from 1 per week, up to 1 per month. Duration of treatment is determined individually.

What is the dose of Cobanzyme (vitamin B12) for a child?

When aplastic anemia, the recommended dose is 100 micrograms before clinical improvement.

When nutritional anemia in infants and preterm, the recommended dose is 30 mcg / day during 15 days.

Dystrophy in young children, Down’ syndrome and cerebral palsy, the recommended dose is by 15-30 mcg every other day.

How is Cobanzyme (vitamin B12) available?

Cobanzyme is available in the following dosage forms and strengths:

  • Capsules; Oral; 1 mg
  • Injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of cobanzyme, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia


Review Date: April 30, 2017 | Last Modified: September 13, 2019

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