What is clomiphene used for?
Clomiphene is a non-steroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary).
Clomiphene is used to cause ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent naturally occurring ovulation.
Clomiphene may also be used for purposes not listed in this medication guide.
How should I take clomiphene?
Use clomiphene exactly as directed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Your doctor will perform medical tests to make sure you do not have conditions that would prevent you from safely using clomiphene.
Clomiphene is usually taken for 5 days, starting on the 5th day of your menstrual period. Follow your doctor’s instructions.
You will need to have a pelvic examination before each treatment cycle. You must remain under the care of a doctor while you are using this medicine.
You will most likely ovulate within 5 to 10 days after you take clomiphene. To improve your chance of becoming pregnant, you should have sexual intercourse while you are ovulating.
Your doctor may have you take your temperature each morning and record your daily readings on a chart. This will help you determine when you can expect ovulation to occur.
In most cases, clomiphene should not be used for more than 3 treatment cycles.
If ovulation occurs but you do not get pregnant after 3 treatment cycles, your doctor may stop treatment and evaluate your infertility further.
How do I store clomiphene?
Clomiphene is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store clomiphene in the bathroom or the freezer. There may be different brands of clomiphene that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.
You should not flush clomiphene down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.
Precautions & warnings
What should I know before using clomiphene?
Before using this drug, tell your doctor if:
- You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
- You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
- You have allergy with any of active or inactive ingredients of clomiphene or other medications.
- You have any other illnesses, disorders, or medical conditions.
You should not use clomiphene if you have:
- Abnormal vaginal bleeding
- An ovarian cyst that is not related to polycystic ovary syndrome
- Past or present liver disease
- A tumor of your pituitary gland
- An untreated or uncontrolled problem with your thyroid or adrenal gland
Clomiphene can pass into breast milk and may harm a nursing baby. This medication may slow breast milk production in some women. Tell your doctor if you are breastfeeding a baby.
Using clomiphene for longer than 3 treatment cycles may increase your risk of developing an ovarian tumor. Ask your doctor about your specific risk.
Fertility treatment may increase your chance of having multiple births (twins, triplets). These are high-risk pregnancies both for the mother and the babies. Talk to your doctor if you have concerns about this risk.
Is it safe during pregnancy or breastfeeding?
There are no adequate studies in women for determining risk when using clomiphene during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking clomiphene. Clomiphene is pregnancy risk category X, according to the US Food and Drug Administration (FDA).
FDA pregnancy risk category reference below:
- A=No risk
- B=No risk in some studies
- C=There may be some risk
- D=Positive evidence of risk
What side effects can occur from clomiphene?
Get emergency medical help if you have any signs of an allergic reaction to clomiphene: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some women using this medicine develop a condition called ovarian hyper-stimulation syndrome (OHSS), especially after the first treatment. OHSS can be a life threatening condition. Call your doctor right away if you have any of the following symptoms of OHSS:
- Stomach pain, bloating
- Nausea, vomiting, diarrhea
- Rapid weight gain, especially in your face and midsection
- Little or no urinating
- Pain when you breathe, rapid heart rate, feeling short of breath (especially when lying down)
Stop using clomiphene and call your doctor at once if you have:
- Pelvic pain or pressure, enlargement in your pelvic area
- Vision problems
- Seeing flashes of light or “floaters” in your vision
- Increased sensitivity of your eyes to light
- Heavy vaginal bleeding
Common clomiphene side effects may include:
- Flushing (warmth, redness, or tingly feeling)
- Breast pain or tenderness
- Breakthrough bleeding or spotting
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
What drugs may interact with clomiphene?
Clomiphene may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Does food or alcohol interact with clomiphene?
Clomiphene may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with clomiphene?
Clomiphene may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
Health conditions that may interact with this drug are endometriosis or uterine fibroids.
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using clomiphene.
What is the dose of clomiphene for an adult?
Usual Adult Dose for Ovulation Induction:
50 mg orally once a day for 5 days. Therapy should be initiated on or near the 5th day of the menstrual cycle, but may be started at any time in patients without recent uterine bleeding.
If ovulation occurs and pregnancy is not achieved, up to 2 additional courses of clomiphene 50 mg orally once a day for 5 days may be administered. Each subsequent course may be started as early as 30 days after the previous course and after pregnancy has been excluded.
Most patients ovulate following the first course of therapy. However, if the patient fails to ovulate, a second course of 100 mg/day for 5 days may be given as early as 30 days following the initial course. A third course of 100 mg/day for 5 days may be given after 30 days, if necessary.
Treatments beyond three cycles of clomiphene, dosages greater than 100 mg once a day, and/or course durations beyond 5 days are not recommended by the manufacturer. However, successful pregnancies and term deliveries have been reported in women receiving up to 200 mg/day for 5 days, or extended 10-day course of therapy, or consecutive cycles of treatment beyond the 3 recommended by the manufacturer.
Usual Adult Dose for Lactation Suppression:
50 to 100 mg orally once a day for 5 days. Generally, one course of therapy is sufficient.
Usual Adult Dose for Oligospermia:
25 to 100 mg orally once a day. Therapy is generally given over a period of several months.
What is the dose of clomiphene for a child?
The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.
How is clomiphene available?
Clomiphene is available in the following dosage forms and strengths:
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of clomiphene, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Clomiphene. http://www.webmd.com/drugs/2/drug-13979/clomiphene-citrate-oral/details. Accessed September 8, 2017
Clomiphene. https://www.drugs.com/clomiphene.html. Accessed September 8, 2017
Review Date: September 8, 2017 | Last Modified: September 13, 2019