Clavulanate + Ticarcillin

By Medically reviewed by hellodoktor

Generic Name: Clavulanate + Ticarcillin Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: B

Uses

What is Clavulanate + Ticarcillin used for?

Clavulanate + Ticarcillin is used to treat bacterial infections in many different parts of the body.

Ticarcillin and clavulanate combination is an antibiotic that belongs to the group of medicines known as penicillins and beta-lactamase inhibitors. It works by killing the bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine was to be given only by or under the direct supervision of a doctor.

How should I take Clavulanate + Ticarcillin?

A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 30 minutes. Tell your doctor if you are on a low-salt diet.

How do I store Clavulanate + Ticarcillin?

Vials: Store intact vials at ≤24°C. Reconstituted solution is stable for 6 hours at room temperature and 72 hours when refrigerated. IV infusion in NS or LR is stable for 24 hours at room temperature (21°C to 24°C), 7 days when refrigerated (4°C), or 30 days when frozen (-18°C). IV infusion in D5W solution is stable for 24 hours at room temperature (21°C to 24°C), 3 days when refrigerated (4°C), or 7 days when frozen (-18°C). After freezing, thawed solution is stable for 8 hours at room temperature. Do not refreeze. Darkening of drug indicates loss of potency of clavulanate potassium.

Premixed solution: Store frozen at ≤-20°C. Thawed solution is stable for 24 hours at room temperature (22°C) or 7 days under refrigeration at (4°C); do not refreeze.

There may be different brands of Clavulanate + Ticarcillin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Clavulanate + Ticarcillin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Clavulanate + Ticarcillin?

Your doctor will check your progress closely while you or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Call your doctor if your symptoms do not improve or if they get worse.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching, hives, hoarseness, shortness of breath, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat after you receive this medicine.

Ticarcillin and clavulanate combination may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Before you have any medical tests, tell the doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Ticarcillin and clavulanate combination may decrease the effects of some oral contraceptives (birth control pills). To avoid an unwanted pregnancy, it is a good idea to use additional contraceptive measures with your pills (e.g. condoms, a diaphragm, or a contraceptive foam or jelly) while using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Clavulanate + Ticarcillin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Clavulanate + Ticarcillin. Clavulanate + Ticarcillin is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Clavulanate + Ticarcillin?

Swelling, redness, pain, or soreness at the injection site may occur. Dizziness, trouble sleeping, nausea, vomiting, diarrhea, or headache may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: muscle cramps/spasms, swelling of the arms/legs/hands/feet, weakness, easy bruising/bleeding, chest pain, confusion, new signs of infection (e.g., fever, persistent sore throat), severe abdominal/stomach pain, slow/fast/irregular heartbeat, persistent nausea/vomiting, seizures, extreme tiredness, dark/cloudy urine, change in the amount of urine, yellowing eyes/skin.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Clavulanate + Ticarcillin?

Some products that may interact with this drug include: “blood thinners” (e.g., enoxaparin, heparin, warfarin), live bacterial vaccines, cancer chemotherapy, lithium, methotrexate, probenecid, tetracyclines, “water pills” (diuretics such as furosemide, hydrochlorothiazide).

Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness. This could cause pregnancy. Examples include rifamycins such as rifampin or rifabutin. Be sure to ask your doctor or pharmacist if you should use additional reliable birth control methods while using this antibiotic.

This medication may interfere with certain laboratory tests (including certain urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Clavulanate + Ticarcillin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Clavulanate + Ticarcillin?

Clavulanate + Ticarcillin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Clavulanate + Ticarcillin?

Clavulanate + Ticarcillin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Clavulanate + Ticarcillin.

What is the dose of Clavulanate + Ticarcillin for an adult?

Usual Adult Dose for Gynecologic Infections

Moderate infections: 200 mg ticarcillin/kg/day in divided doses every 6 hours (maximum: 12 g daily)

Severe infections: 300 mg ticarcillin/kg/day in divided doses every 4 hours (maximum: 18 g daily)

Usual Adult Dose for Systemic Infections

<60 kg: 200-300 mg ticarcillin/kg/day in divided doses every 4-6 hours (maximum: 18 g daily)

≥60 kg: 3.1 g every 4-6 hours

Usual Adult Dose ofr Urinary Tract Infections

<60 kg: 200-300 mg ticarcillin/kg/day in divided doses every 4-6 hours (maximum: 18 g daily)

≥60 kg: 3.1 g every 4-6 hours

Intra-abdominal infection, complicated, community-acquired, mild-to-moderate (off-label use): IV: 3.1 g every 6 hours for 4-7 days (provided source controlled) (Solomkin, 2010)

What is the dose of Clavulanate + Ticarcillin for a child?

Usual Pediatric Dose for Mild to Moderate Infections

Infants ≥3 months, Children, and Adolescents:

<60 kg: 200 mg ticarcillin/kg/day in divided doses every 6 hours (maximum: 12 g daily)

≥60 kg: 3.1 g every 6 hours

Usual Pediatric Dose for Severe Infections

Infants ≥3 months, Children, and Adolescents:

<60 kg: 300 mg ticarcillin/kg/day in divided doses every 4 hours. (maximum: 18 g daily)

≥60 kg: 3.1 g every 4 hours

Cystic fibrosis (off-label use): Infants, Children, and Adolescents: IV: 400 mg ticarcillin/kg/day in divided doses every 6 hours; higher doses have been used: 400-750 mg ticarcillin/kg/day in divided doses every 6 hours (maximum: 24-30 g ticarcillin daily) (Zobell, 2013)

Intra-abdominal infection, complicated (off-label use): Infants, Children, and Adolescents: IV: 200-300 mg ticarcillin/kg/day in divided every 4-6 hours (Solomkin, 2010)

How is Clavulanate + Ticarcillin available?

Clavulanate + Ticarcillin is available in the following dosage forms and strengths:

  • Powder for Solution
  • Solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Clavulanate + Ticarcillin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: September 2, 2018 | Last Modified: September 12, 2019

Sources
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