Generic Name: Chlorpheniramine Brand Name(s): Generics only. No brands available.


What is chlorpheniramine used for?

Chlorpheniramine is commonly used for relieving symptoms of sinus congestion, sinus pressure, runny nose, watery eyes, itching of the nose and throat, and sneezing due to upper respiratory infections (e.g., colds), allergies, and hay fever.

Chlorpheniramine may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take chlorpheniramine?

Take the tablet or liquid form by mouth with or without food. Follow the directions for dosing on the label, or take as directed by your doctor. This medication may be taken with food or milk if stomach upset occurs.

  • Tablet form: Do not crush or chew tablets. Drink a full glass of water.
  • Liquid form: Use a medication-measuring device to carefully measure the prescribed dose. Do not use a household spoon. If your liquid form is a suspension, shake the bottle well before each dose.

Ask your health care provider any questions you may have about how to use this medication.

How do I store chlorpheniramine?

Chlorpheniramine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store chlorpheniramine in the bathroom or the freezer. There may be different brands of chlorpheniramine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush chlorpheniramine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using chlorpheniramine?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of chlorpheniramine product or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from chlorpheniramine?

Chlorpheniramine may cause following side effects, such as:

  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry mouth, nose, or throat
  • Excitability
  • Headache
  • Loss of appetite
  • Nausea
  • Nervousness or anxiety
  • Trouble sleeping
  • Upset stomach
  • Vomiting
  • Weakness

Seek medical attention right away if any of these severe side effects occur while taking chlorpheniramine:

  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Difficulty urinating or inability to urinate
  • Fast or irregular heartbeat
  • Hallucinations
  • Seizures
  • Severe dizziness, lightheadedness, or headache
  • Tremor
  • Trouble sleeping
  • Vision changes

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with chlorpheniramine?

Chlorpheniramine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some products that may interact with this drug include:

  • A sleeping pill
  • Narcotic pain medicine
  • Muscle relaxer
  • Medicine for anxiety, depression, or seizures

Does food or alcohol interact with chlorpheniramine?

Chlorpheniramine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with chlorpheniramine?

Chlorpheniramine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • Narrow-angle glaucoma
  • A blockage in your stomach or intestines
  • An enlarged prostate
  • Unable to urinate
  • An asthma attack


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of chlorpheniramine for an adult?

Allergic Rhinitis:

The recommended dose is 4 mg orally every 4-6 hours; not to exceed 24 mg/day.

What is the dose of chlorpheniramine for a child?

Allergic Rhinitis

  • <2 years: Safety & efficacy not established.
  • 2-6 years: The recommended dose is 1 mg orally every 4-6 hours; not to exceed 6 mg/day.
  • 6-12 years: The recommended dose is 2 mg orally every 4-6 hours; not to exceed 12 mg/day.
  • >12 years: The recommended dose is 4 mg orally every 4-6 hours; not to exceed 24 mg/day.

How is chlorpheniramine available?

Chlorpheniramine is available in the following dosage forms and strengths:

  • Tablet 4mg, 8mg, 12mg
  • Syrup 2mg/5mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of chlorpheniramine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: June 2, 2017 | Last Modified: June 2, 2017

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