What is celecoxib?

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Generic Name: Celecoxib Brand Name(s): Generics only. No brands available.

Know the basics

What is celecoxib used for?

Celecoxib is used to treat arthritis, acute pain, and menstrual pain and discomfort. It belongs to a drug class called nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling (inflammation).

The pain and swelling relief provided by celecoxib helps you manage your normal daily activities. If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

Celecoxib works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.

Celecoxib may also be used to treat gout attacks.

How should I take celecoxib?

Read the Medication Guide provided by your pharmacist before you start using celecoxib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take celecoxib by mouth as directed by your doctor, usually once or twice daily. To decrease the chance of stomach upset, this drug is best taken with food. The dosage is based on your medical condition and response to treatment. Take this medication at the lowest effective dose and only for the prescribed length of time (see also Warning section).

Take celecoxib with a full glass of water (240 millilitres) unless your doctor directs you otherwise. Do not lie down for 10 minutes after taking celecoxib.

For certain conditions (such as arthritis), it may take up to two weeks of taking this drug regularly before you get the full benefit.

If you are taking this drug on an “as needed” basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

How do I store celecoxib?

Celecoxib is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store celecoxib in the bathroom or the freezer. There may be different brands of celecoxib that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush celecoxib down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using celecoxib?

Do not use celecoxib just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking celecoxib, especially in older adults.

You should not use this medication if you are allergic to celecoxib, or if you have a history of allergic reaction to aspirin, sulfa drugs, or other NSAIDs.

Is it safe to take celecoxib during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Know the side effects

What are the side effects of celecoxib?

Get emergency medical help if you have any of these signs of an allergic reaction:

  • hives;
  • difficulty breathing;
  • swelling of your face, lips, tongue, or throat.

Stop using celecoxib and call your doctor at once if you have a serious side effect such as:

  • chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • swelling or rapid weight gain;
  • urinating less than usual or not at all;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or
  • severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • upset stomach, diarrhea, bloating, gas;
  • dizziness, nervousness, headache;
  • runny or stuffy nose, sore throat; or
  • mild skin rash.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with celecoxib?

Celecoxib may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, non-prescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or non-prescription (over-the-counter [OTC]) medicine.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab, Anarelide, Apixaban, Ardeparin, Argatroban, Beta Glucan, Bivalirudin, Ceritinib, Certoparin, Cilostazol, Citalopram, Clopidogrel, Clovoxamine, Cyclosporine, Dabigatran Etexilate, Dabrafenib, Dalteparin, Danaparoid, Desirudin, Dipyridamole, Duloxetine, Enoxaparin, Eptifibatide, Erlotinib, Escitalopram, Femoxetine, Feverfew, Flesinoxan, Fluoxetine, Fondaparinux, Ginkgo, Gossypol, Heparin, Lepirudin, Levomilnacipran, Meadowsweet, Methotrexate, Milnacipran, Nadroparin, Nefazodone, Nitisinone, Parnaparin, Paroxetine, Pemetrexed, Pentosan Polysulfate Sodium, Pentoxifylline, Pralatrexate, Prasugrel, Protein C, Reviparin, Rivaroxaban, Sibutramine, Tacrolimus, Ticlopidine, Tinzaparin, Tirofiban, Venlafaxine, Vilazodone, Vortioxetine, Warfarin, Zimeldine.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol, Acetohexamide, Alacepril, Alprenolol, Amiloride, Amlodipine, Arotinolol, Aspirin, Atenolol, Azilsartan Medoxomil, Azosemide, Befunolol, Bemetizide, Benazepril, Bendroflumethiazide, Benzthiazide, Bepridil, Betaxolol, Bevantolol, Bisoprolol, Bopindolol, Bucindolol, Bumetanide, Bupranolol, Buthiazide, Candesartan Cilexetil, Canrenoate, Captopril, Carteolol, Carvedilol, Celiprolol, Chlorothiazide, Chlorpropamide, Chlorthalidone, Cilazapril, Clopamide, Cyclopenthiazide, Delapril, Desvenlafaxine, Dilevalol, Diltiazem, Enalaprilat, Enalapril Maleate, Eprosartan, Esmolol, Ethacrynic Acid, Felodipine, Fluconazole, Flunarizine, Fosinopril, Furosemide, Gallopamil, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glyburide, Hydrochlorothiazide, , Hydroflumethiazide, Imidapril, Indapamide, Irbesartan, Isradipine, Labetalol, Lacidipine, Landiolol, Levobunolol, Lidoflazine, Lisinopril, Lithium, Losartan, Manidipine, Mepindolol, Methyclothiazide, Metipranolol, Metolazone, Metoprolol, Moexipril, Nadolol, Nebivolol, Nicardipine, Nifedipine, Nilvadipine, Nimodipine, Nipradilol, Nisoldipine, Nitrendipine, Olmesartan Medoxomil, Oxprenolol, Penbutolol, Pentopril, Perindopril, Pindolol, Piretanide, Polythiazide, Pranidipine, Propranolol, Quinapril, Ramipril, Sotalol, Spirapril, Spironolactone, Talinolol, Tasosartan, Telmisartan, Temocapril, Tertatolol, Timolol, Tolazamide, Tolbutamide, Torsemide, Trandolapril, Triamterene, Trichlormethiazide, Valsartan, Verapamil, Xipamide, Zofenopril.

Does food or alcohol interact with celecoxib?

Celecoxib may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with celecoxib?

Celecoxib may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Anemia;
  • Congestive heart failure;
  • Edema (fluid retention or body swelling);
  • Heart attack, history of;
  • Heart disease;
  • Hypertension (high blood pressure);
  • Kidney disease, mild to moderate;
  • Stomach ulcers or bleeding, history of;
  • Stroke, history of—Use with caution. May make these conditions worse.
  • Aspirin-sensitive asthma, history of;
  • Aspirin sensitivity, history of;
  • Kidney impairment, severe;
  • Liver impairment, severe;
  • Sulfa or sulfonamide allergy (e.g., sulfamethoxazole, Bactrim®, or Septra®)—Should not be used in patients with these conditions.
  • Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—This medicine should not be used to relieve pain right before or after the surgery.
  • Certain genetic conditions (poor CYP2C9 (a liver enzyme) metabolizers);
  • Liver disease, mild or moderate—Use with caution. You may need a reduced dose of this medicine.

Understand the dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before using this medication.

What is the dose of Celecoxib for an adult?

Usual Adult Celecoxib Dose for Pain:

Acute pain: 400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.

Usual Adult Celecoxib Dose for Dysmenorrhea:

400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.

Usual Adult Celecoxib Dose for Osteoarthritis:

200 mg orally once daily or 100 mg orally twice daily.

Usual Adult Celecoxib Dose for Rheumatoid Arthritis:

100 to 200 mg orally twice daily.

Usual Adult Dose for Familial Adenomatous Polyposis:

400 mg orally twice daily with food.

Usual Adult Dose for Ankylosing Spondylitis:

200 mg orally once daily or 100 mg orally twice daily. If after 6 weeks of therapy no results are observed, a trial dose of 400 mg orally daily may be worthwhile. If no response is seen after 6 weeks, consideration should be given to alternate treatment options.

What is the dose of Celecoxib for a child?

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

2 years or older:

10 to less than or equal to 25 kg: 50 mg orally twice daily

Greater than 25 kg: 100 mg orally twice daily

How is celecoxib available?

Celecoxib is available in the following dosage forms and strengths:

  • Capsule, oral: 50mg, 100mg, 200mg, 400mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

Symptoms of overdose may include:

  • lack of energy;
  • drowsiness;
  • nausea;
  • vomiting;
  • stomach pain;
  • vomiting material that is bloody or looks like coffee grounds;
  • bloody or black, tarry stools;
  • loss of consciousness;
  • hives;
  • rash;
  • swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs;
  • difficulty breathing or swallowing.

What should I do if I miss a dose?

If you miss a dose of celecoxib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 4, 2017 | Last Modified: January 4, 2017

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