Generic Name: Cefamandole Brand Name(s): Generics only. No brands available.


What is cefamandole used for?

Cefamandole is commonly used for treatment of serious infections caused by susceptible strains of the designated microorganisms in the diseases listed below:

How should I take cefamandole?

It comes as a solution for injection, to be administered by a healthcare provider into the vein or muscle.

How do I store cefamandole?

Reconstituted cefamandole is stable for 24 hours at room temperature (25°C) and for 96 hours if stored under refrigeration (5°C). During storage at room temperature, carbon dioxide develops inside the vial after reconstitution. This pressure may be dissipated prior to withdrawal of the vial contents, or it may be used to aid withdrawal if the vial is inverted over the syringe needle and the contents are allowed to flow into the syringe.

Solutions of cefamandole in sterile water for injection, 5% dextrose injection, or 0.9% sodium chloride injection that are frozen immediately after reconstitution in the conventional vials in which the drugs are supplied are stable for 6 months when stored at -20°C. If the product is warmed (to a maximum of 37°C), care should be taken to avoid heating it after the thawing is complete. Once thawed, the solution should not be refrozen.

Precautions & warnings 

What should I know before using Cefamandole?

Before using this drug, tell your doctor if you have had previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs.

This product should be given cautiously to penicillin-sensitive patients. Antibiotics should be administered with caution to any patient who has demonstrated some form of allergy, particularly to drugs. Serious acute hypersensitivity reactions may require epinephrine and other emergency measures.

Is it safe during pregnancy or breastfeeding?


There are no adequate studies in women for determining risk when using cefamandole during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking cefamandole. Cefamandole is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Cefamandole is excreted into human milk in small amounts. Adverse effects in the nursing infant are unlikely.

Side effects 

What side effects can occur from cefamandole?

Some side effects can occur, including:

  • Hypersensitivity anaphylaxis
  • Maculopapular rash
  • Urticaria 
  • Eosinophilia
  • Fever
  • Gastrointestinal symptoms of pseudomembranous colitis

Also, rare side effects are:

  • Nausea
  • Vomiting
  • Transient hepatitis
  • Cholestatic jaundice
  • Blood thrombocytopenia
  • Neutropenia
  • Liver transient
  • Alkaline phosphatase levels
  • Kidney decreased creatinine clearance
  • Local reactions
  • Thrombophlebitis

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with cefamandole?

Cefamandole may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with cefamandole?

Cefamandole may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with cefamandole?

Cefamandole may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using cefamandole.

What is the dose of cefamandole for an adult?

The usual dosage range for cefamandole is 500 mg to 1 g every 4 to 8 hours.

In infections of skin structures and in uncomplicated pneumonia, a dosage of 500 mg every 6 hours is adequate.

In uncomplicated urinary tract infections, a dosage of 500 mg every 8 hours is sufficient. In more serious urinary tract infections, a dosage of 1 g every 8 hours may be needed.

In severe infections, 1-g doses may be given at 4 to 6-hour intervals.

In life-threatening infections or infections due to less susceptible organisms, doses up to 2 g every 4 hours (ie, 12 g/day) may be needed.

What is the dose of cefamandole for a child?

Administration of 50 to 100 mg/kg/ day in equally divided doses every 4 to 8 hours has been effective for most infections susceptible to cefamandole. This may be increased to a total daily dose of 150 mg/kg (not to exceed the maximum adult dose) for severe infections.

How is cefamandole available?

Cefamandole is available in the following dosage forms and strengths:

  • Injection 1g/5ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of cefamandole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 23, 2017 | Last Modified: February 6, 2017

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