Calypsol

By Medically reviewed by hellodoktor

Generic Name: Calypsol Brand Name(s): Generics only. No brands available.

Uses

What is calypsol used for?

Calypsol is commonly used for inducing anesthesia (lack of sensation or feeling) before surgery or certain procedures that do not require skeletal muscle relaxation.

How should I take calypsol?

Ketamine is usually administered as an injection at your doctor’s office, hospital, or clinic by those experienced in administering general anesthetics, in maintaining an airway, and in controlling respiration.

How do I store calypsol?

Calypsol is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store calypsol in the bathroom or the freezer. There may be different brands of calypsol that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush calypsol down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using calypsol?

Before taking this drug, tell your doctor if:

  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • You have a history of alcoholism or you are intoxicated by alcohol.
  • You take calypsol before you receive any medical or dental care, emergency care, or surgery.
  • You are allergic to any ingredient in calypsol.
  • You have a condition in which a large increase in blood pressure would be harmful.
  • You are taking droxidopa.

Calypsol may cause drowsiness for up to 24 hours. These effects may be worse if you take it with alcohol or certain medicines. Do not drive or perform other possibly unsafe tasks for at least 24 hours following surgery until you know how you react to it.

Calypsol may cause behavior, mental, or mood changes; confusion; or hallucinations that usually go away within 24 hours. Discuss any questions or concerns with your doctor.

Use calypsol with caution in the elderly; they may be more sensitive to its effects.

Calypsol should be used with extreme caution in children younger than 16 years old; safety and effectiveness in these children have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from calypsol?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Loss of appetite
  • Nausea
  • Vomiting

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Behavior changes
  • Confusion
  • Difficult, frequent, or painful urination
  • Double vision
  • Fainting
  • Fast, slow, or irregular heartbeat
  • Hallucinations
  • Involuntary muscle movements
  • Mental or mood changes (e.g., anxiety);
  • Pain, redness, or swelling at the injection site
  • Severe or persistent dizziness, light-headedness, or headache
  • Slowed or shallow breathing
  • Uncontrolled eye movements

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with calypsol?

Caplysol may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

These products may include:

  • Carbinoxamine (Karbinal ER, Arbinoxa, Palgic, and many others)
  • Topical cocaine or cocaine applied to the nose
  • Doxylamine (Unisom)
  • Opioids, such as  alfentanil, codeine, hydromorphone (Dilaudid), and oxymorphone (Opana)
  • Tramadol (Conzip, Ultram, Ultram ER, Ultracet)
  • Barbiturates like butalbital, butabarbital (Butisol), and pentobarbital
  • Benzodiazepines, such as like alprazolam (Xanax), clonazepam (Klonopin), and lorazepam (Ativan)
  • Carbamazepine (Carbatrol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenytoin (Dilantin)
  • Zaleplon (Sonata, Starnoc, Andanta) or zolpidem (Ambien)
  • Rifampin (Rifadin, Rifamate, Rimactane)
  • Dexmedetomidine (Precedex)
  • Suvorexant (Belsomra)

Does food or alcohol interact with calypsol?

Calypsol may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with calypsol?

Calypsol may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • History of head trauma or injury, bleeding in the brain
  • A stroke
  • Increased spinal fluid pressure
  • Increased pressure in the eye
  • Bladder or urinary problems
  • Heart problems (e.g., congestive heart failure)
  • High blood pressure
  • Mental or mood problems
  • Thyroid problems

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using calypsol.

What is the dose of calypsol for an adult?

IV:

Induction: the recommended dose is 1 to 4.5 mg/kg IV; alternatively, 1 to 2 mg/kg IV at a rate of 0.5 mg/kg/min; (2 mg/kg dose provides 5 to 10 minutes of surgical anesthesia within 30 seconds).

The maintenance dose should be adjusted according to the patient’s anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.

IM:

Induction: the recommended dose is 6.5 to 13 mg/kg IV; (9 to 13 mg/kg IV provides 12 to 25 minutes of surgical anesthesia).

The maintenance dose should be adjusted according to the patient’s anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.

What is the dose of calypsol for a child?

Children 16 years-old

IV:

Induction: the recommended dose is 1 to 4.5 mg/kg IV; alternatively, 1 to 2 mg/kg IV at a rate of 0.5 mg/kg/min; (2 mg/kg dose provides 5 to 10 minutes of surgical anesthesia within 30 seconds).

The maintenance dose should be adjusted according to the patient’s anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.

IM:

Induction: the recommended dose is 6.5 to 13 mg/kg IV; (9 to 13 mg/kg IV provides 12 to 25 minutes of surgical anesthesia).

The maintenance dose should be adjusted according to the patient’s anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.

How is calypsol available?

Calypsol is available in the following dosage forms and strengths:

  • Injection, solution 500mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of calypsol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 18, 2017 | Last Modified: September 13, 2019

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