Calcium Folinate

By Medically reviewed by hellodoktor

Generic Name: Calcium Folinate Brand Name(s): Generics only. No brands available.


What is calcium folinate used for?

Calcium folinate is commonly used for the treatment or prevention of serious blood cell disorders such as anemia, thrombocytopenia. Also, it is used with certain cancer drug to treat patients with colon cancer.

It may also be used to treat other conditions as determined by your doctor.

How should I take calcium folinate?

Calcium folinate is injected by your doctor into a vein or a muscle, usually every 6 hours or once daily.

If you use this drug at home, ask your doctor how to prepare and usage instructions.

How do I store calcium folinate?

Calcium folinate is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of calcium folinate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush calcium folinate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using calcium folinate?

Before using calcium folinate, tell your doctor if:

  • You are allergic to any ingredient in calcium folinate.
  • You have pernicious anemia or other anemia due to low blood levels of vitamin B12.
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.

Lab tests, including blood methotrexate levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from calcium folinate?

Consult your doctor immediately if any of these severe side effects occur:

  • Rash
  • Hives
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Fainting
  • Seizures

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with calcium folinate?

Calcium folinate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with your drug, such as:

  • Fluorouracil, because side effects and toxicity, including inflammation of the mouth or severe diarrhea, may be increased.
  • Trimethoprim-sulfamethoxazole, because effectiveness may be decreased.
  • Phenobarbital, phenytoin, or primidone, because effectiveness may be decreased and seizure frequency may increase in some children.

Does food or alcohol interact with calcium folinate?

Calcium folinate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with calcium folinate?

Calcium folinate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have. Especially if you have blood problems (e.g., anemia).


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using calcium folinate.

What is the dose of calcium folinate for an adult?

Your doctor will work out the correct dose for you and how often it must be given. It depends upon the medical condition which is being treated.

What is the dose of calcium folinate for a child?

Your doctor will work out the correct dose for you and how often it must be given. It depends upon the medical condition which is being treated.

How is calcium folinate available?

Calcium folinate is available in the following dosage forms and strengths:

  • 10mg/ml injectable solution
  • 100mg injectable powder for injection
  • 200mg injectable powder for injection
  • 350mg injectable powder for injection
  • 50mg injectable powder for injection
  • 500mg injectable powder for injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of calcium folinate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: April 5, 2017 | Last Modified: September 12, 2019

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