Generic Name: Cabazitaxel Brand Name(s): Generics only. No brands available.

Uses

What is Cabazitaxel used for?

Cabazitaxel is used with another medication (prednisone) to treat prostate cancer. It works by slowing or stopping the growth of cancer cells.

How should I take Cabazitaxel?

This medication is given by injection into a vein as directed by your doctor, usually every 3 weeks. A health care professional will give you the injection slowly over 1 hour.

Your doctor may prescribe other medications (such as antihistamines, H2 blockers, corticosteroids) before each injection of cabazitaxel to lessen the risk of allergic reactions and prevent side effects such as nausea/vomiting.

The dosage is based on your medical condition, body size, lab tests, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

How do I store Cabazitaxel?

Store intact vials at 25°C (77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). Do not refrigerate. Do not prepare or administer in PVC-containing infusion containers or polyurethane infusion sets. The initial reconstituted solution (at 10 mg/mL) is stable for 30 minutes in the vial and solutions for infusion are stable for up to 8 hours at room temperature (includes the 1 hour infusion) or 24 hours refrigerated (includes the 1 hour infusion).

To prevent drug damage, you should not store Cabazitaxel in the bathroom or the freezer. There may be different brands of Cabazitaxel that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Cabazitaxel down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Cabazitaxel?

Before receiving cabazitaxel, tell your doctor or pharmacist if you are allergic to it; or to polysorbate 80; or if you have any other allergies. This product may contain other inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, lung disease, blood/bone marrow disorders (such as bone marrow suppression, neutropenia, thrombocytopenia, anemia), stomach/abdominal problems (such as ulcers, bleeding, blockage), recent/current infections, radiation treatment.

Cabazitaxel can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be at greater risk for side effects (such as low number of white blood cells, fever, dizziness, bladder infections, dehydration/loss of too much body water) while using this drug.

This medication should not be used in women, especially during pregnancy or breast-feeding. It may harm an unborn or breast-feeding baby. Men using this medication should ask about reliable forms of birth control while using this medication and for 3 months after stopping treatment. Consult your doctor for more details.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Cabazitaxel during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Cabazitaxel. Cabazitaxel is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Cabazitaxel?

Loss of appetite, stomach/abdominal pain, or change in sense of taste may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Nausea, vomiting, and diarrhea can also occur and may be severe. Tell your doctor right away if these effects occur. In some cases, your doctor may prescribe medication to prevent or relieve nausea, vomiting, or diarrhea. Eating several small meals, not eating before treatment, or limiting activity may help to lessen the nausea and vomiting.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Many people using this medication develop serious side effects. However, your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine, pink/bloody urine), signs of a bladder infection (such as burning/pain when you urinate, urgent or frequent urination, fever), muscle cramps, weakness, dizziness, extreme thirst, unusual tiredness, fast/irregular heartbeat, easy bruising/bleeding, numbness/tingling of arms/legs, persistent constipation, severe stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds.

Get medical help right away if you have any very serious side effects, including: chest pain.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Cabazitaxel?

Some products that may interact with this drug include: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, “blood thinners” such as warfarin/dabigatran).

Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Other medications can affect the removal of cabazitaxel from your body, which may affect how cabazitaxel works. Examples include azole antifungals (such as itraconazole, ketoconazole), cobicistat, macrolide antibiotics (such as clarithromycin), HIV protease inhibitors (such as ritonavir, nelfinavir), nefazodone, telithromycin, among others.

Cabazitaxel may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Cabazitaxel?

Cabazitaxel may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Cabazitaxel?

Cabazitaxel may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Cabazitaxel.

What is the dose of Cabazitaxel for an adult?

Usual Adult Dose for Prostate Cancer

25 mg/m2 IV over 1 hour every three weeks

Comments:

-Use in combination with prednisone or prednisolone.

-Give premedication regimen at least 30 minutes prior to each administration.

-Give antiemetics prophylactically or as needed.

-Ensure adequate hydration throughout treatment.

Use: Use in combination with prednisone or prednisolone for the treatment of patients with hormone refractory metastatic prostate cancer previously treated with a docetaxel containing regimen.

Renal Dose Adjustments

CrCl 50 to 80 mL/min: No adjustment necessary

CrCl less than 50 mL/min or end stage renal disease: Use with caution and monitor carefully during treatment.

Liver Dose Adjustments

Not recommended

Dose Adjustments

Adjust dosage for the following adverse events:

-Prolonged (more than 1 week) Grade 3 or higher neutropenia despite appropriate medication including G-CSF: Delay treatment until neutrophil count is greater than 1,500 cells/mm3, then reduce dose to 20 mg/m2.

-Febrile neutropenia or neutropenic infection: Delay treatment until improvement or resolution, and neutrophil count is greater than 1,500 cells/mm3, then reduce dose to 20 mg/m2.

-Grade 3 or higher, or persisting diarrhea despite appropriate medication, fluid, and electrolytes replacement: Delay treatment until improvement or resolution, then reduce dose to 20 mg/m2.

-Grade 2 or higher peripheral neuropathy: Delay treatment until improvement or resolution, then reduce dose to 20 mg/m2.

-Discontinue treatment if patient continues to experience any of these reactions at 20 mg/m2.

Other Comments

Administration advice:

-Do not use PVC infusion containers for preparation or infusion.

-Do not use polyurethane infusion sets for administration.

-Use an in-line 0.22 micrometer filter during administration.

Storage requirements: Do not refrigerate.

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility: Do not mix with other medications.

General:

-Administer under the supervision of a physician experienced in the use of antineoplastics.

-Facilities and equipment for the treatment of serious hypersensitivity reactions, like hypotension and bronchospasm, must be available.

Patient advice:

-Educate patients about risk of hypersensitivity and to immediately report signs of hypersensitivity reactions.

-Explain the importance of routine blood cell counts.

-Have patients monitor their temperature frequently and immediately report fever.

-Explain the importance of taking corticosteroids as instructed.

-Inform patients of infection, dehydration, and renal failure risk; instruct patients to immediately report fever, significant vomiting or diarrhea, decreased urinary output, and hematuria.

What is the dose of Cabazitaxel for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Cabazitaxel available?

Cabazitaxel is available in the following dosage forms and strengths:

  • Intravenous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Cabazitaxel, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: June 4, 2018 | Last Modified: June 4, 2018

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.