By Medically reviewed by hellodoktor

Generic Name: Bystolic Brand Name(s): Bystolic.


What is Bystolic® (nebivolol) used for?

Bystolic® blockers affect the heart and circulation (blood flow through arteries and veins). Bystolic® is used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack.

Bystolic® may also be used for other purposes not listed in this medication guide.

How should I take Bystolic® (nebivolol)?

Take Bystolic® exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Bystolic® at the same time every day. You may take the medication with or without food.

Do not skip doses or stop taking Bystolic® without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems such as severe chest pain or heart attack. You may need to use less and less before you stop the medication completely.

Your blood pressure will need to be checked often. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using Bystolic®.

Bystolic® is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Keep using Bystolic® as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

How do I store Bystolic® (nebivolol)?

Bystolic® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Bystolic® in the bathroom or the freezer. There may be different brands of Bystolic® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Bystolic® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Bystolic® (nebivolol)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Bystolic® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

To make sure you can safely take Bystolic®, tell your doctor if you have any of these other conditions:

  • Severe liver disease
  • A heart problem such as heart block, sick sinus syndrome, slow heart rate, or heart failure

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Bystolic® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Bystolic®. Bystolic® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Bystolic® (nebivolol)?

Get emergency medical help if you have any of these signs of an allergic reaction to Bystolic®: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • Feeling short of breath, even with mild exertion
  • Swelling of your ankles or feet
  • Slow or uneven heartbeats
  • Numbness or cold feeling in your hands and feet

Less serious side effects may include:

  • Headache
  • Tired feeling
  • Nausea, stomach pain
  • Diarrhea
  • Sleep problems (insomnia)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Bystolic® (nebivolol)?

Bystolic® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Cimetidine (Tagamet)
  • Clonidine (Catapres)
  • Digitalis (digoxin, Lanoxin)
  • Isoniazid (for treating tuberculosis)
  • Methimazole (Tapazole)
  • Reserpine
  • Ropinirole (Requip)
  • Ticlopidine (Ticlid)
  • Another beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others
  • An antibiotic such as terbinafine (Lamisil)
  • An antidepressant such as clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax), imipramine (Tofranil), paroxetine (Paxil, Pexeva), sertraline (Zoloft), or tranylcypromine (Parnate)
  • Anti-malaria medication such as chloroquine (Aralen) or pyrimethamine (Daraprim), or quinine (Qualaquin)
  • Heart or blood pressure medicine such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), clonidine (Catapres, Clorpres, Kapvay, Nexiclon), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), nicardipine (Cardene), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others
  • Heart rhythm medicine such as amiodarone (Cordarone, Pacerone), quinidine (Quin-G), procainamide (Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), and others
  • HIV or AIDS medicine such as delavirdine (Rescriptor) or ritonavir (Norvir, Kaletra)
  • Medicine to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril)

Does food or alcohol interact with Bystolic® (nebivolol)?

Bystolic® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Bystolic® (nebivolol)?

Bystolic® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Asthma, bronchitis, emphysema
  • Liver or kidney disease
  • Diabetes
  • A thyroid disorder
  • A history of allergies
  • Problems with circulation (such as Raynaud’s syndrome)
  • Pheochromocytoma (tumor of the adrenal gland)
  • A heart attack


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Bystolic® (nebivolol).

What is the dose of Bystolic® (nebivolol) for an adult?


The dose must be individualized to the needs of the patient. For most patients, the recommended starting dose is 5 mg once daily, with or without food, as monotherapy or in combination with other agents.

For patients requiring further reduction in blood pressure, the dose can be increased at 2-week intervals up to 40 mg. A more frequent dosing regimen is unlikely to be beneficial.

What is the dose of Bystolic® (nebivolol) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Bystolic® (nebivolol) available?

Bystolic® is available in the following dosage forms and strengths:

  • Tablet: nebivolol hydrochloride 5mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Bystolic®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: July 31, 2017 | Last Modified: September 13, 2019

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