Generic Name: Brilinta Brand Name(s): Generics only. No brands available.

Uses

What is Brilinta® (ticagrelor) used for?

Brilinta® helps to prevent platelets in your blood from sticking together and forming a blood clot. An unwanted blood clot can occur with certain heart or blood vessel conditions.

Brilinta® is used to lower your risk of having a stroke or serious heart problems after you have had a heart attack or severe chest pain (angina).

Brilinta® may also be used for purposes not listed in this medication guide.

How should I take Brilinta® (ticagrelor)?

Take Brilinta® exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Brilinta® should be taken together with aspirin. Follow your doctor’s instructions about how much aspirin you should take.

Do not take more aspirin than your doctor has prescribed. Taking too much aspirin can make Brilinta® less effective.

This medicine can be taken with or without food. Take the medicine at the same time each day.

Because ticagrelor keeps your blood from coagulating (clotting), this medicine can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have any bleeding that will not stop.

Any doctor, dentist, surgeon, or other medical care provider who treats you should know that you are taking Brilinta®. You may need to stop using the medicine for a short time before having surgery or dental work, to prevent excessive bleeding. Follow your doctor’s instructions and start taking Brilinta® again as soon as possible.

Do not stop taking Brilinta® without first talking to your doctor, even if you have signs of bleeding. Use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Stopping Brilinta® may increase your risk of a heart attack or stroke.

How do I store Brilinta® (ticagrelor)?

Brilinta® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Brilinta® in the bathroom or the freezer. There may be different brands of Brilinta® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Brilinta® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product

Precautions & warnings

What should I know before using Brilinta® (ticagrelor)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Brilinta® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have severe liver disease, any active bleeding (including a bleeding stomach ulcer), or a history of bleeding in the brain. Do not use this medicine just before heart bypass surgery (coronary artery bypass graft, or CABG).

You may need to stop using Brilinta® for a short time before having surgery or dental work, to prevent excessive bleeding. Do not stop taking Brilinta® without first talking to your doctor, even if you have signs of bleeding. Stopping this medicine may increase your risk of a heart attack or stroke.

Brilinta® may cause you to bleed more easily, especially if you have:

  • A recent surgery or bleeding injury
  • A disease affecting the blood vessels in your brain
  • A history of stroke
  • A history of bleeding problems
  • A history of stomach or intestinal bleeding
  • If you are 65 or older

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Brilinta® (ticagrelor)?

Get emergency medical help if you have signs of an allergic reaction to Brilinta®: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • A nosebleed or other bleeding that will not stop
  • Shortness of breath or a light-headed feeling (like you might pass out), even with mild exertion or while lying down
  • Easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin
  • Red or pink urine
  • Pale skin, weakness, fever, or jaundice (yellowing of the skin or eyes)
  • Signs of stomach bleeding – bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
  • Heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating
  • Signs of a stroke – sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance

Common side effects may include:

  • Headache, mild dizziness
  • Cough
  • Nausea, diarrhea

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Brilinta® (ticagrelor)?

Brilinta® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Imatinib
  • Lovastatin (Advicor, Altoprev, Mevacor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync)
  • Nefazodone
  • John’s wort
  • An antibiotic – clarithromycin, telithromycin
  • Antifungal medicine – itraconazole, ketoconazole, posaconazole, voriconazole
  • Heart or blood pressure medicine – digoxin, nicardipine, quinidine
  • Antiviral medicine to treat hepatitis or HIV/AIDS – atazanavir, boceprevir, cobicistat, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir
  • Seizure medicine – carbamazepine, phenytoin
  • Tuberculosis medicine – isoniazid, rifampin

Does food or alcohol interact with Brilinta® (ticagrelor)?

Brilinta® may interact with food by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Brilinta® (ticagrelor)?

Brilinta® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Liver disease
  • A serious heart condition such as “sick sinus syndrome” or “AV block” (unless you have a pacemaker)
  • Asthma, COPD (chronic obstructive pulmonary disorder) or other breathing problem
  • A history of stomach ulcer or colon polyps
  • A history of stroke
  • A history of bleeding or blood clotting disorder

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Brilinta® (ticagrelor).

What is the dose of Brilinta® (ticagrelor) for an adult?

Initiate treatment with a 180 mg (two 90 mg tablets) loading dose given orally and continue treatment with 90 mg orally twice daily. After the initial loading dose of aspirin (usually 325 mg), use a daily maintenance dose of aspirin of 75 to 100 mg.

Maintenance doses of aspirin above 100 mg decreased the effectiveness of Brilinta®. Avoid maintenance doses of aspirin above 100 mg daily.

What is the dose of Brilinta® (ticagrelor) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Brilinta® (ticagrelor) available?

Brilinta® is available in the following dosage forms and strengths:

  • Brilinta® 60mg tablet
  • Brilinta® 90mg tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Brilinta®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: September 2, 2017 | Last Modified: September 2, 2017

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.