Brigatinib

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Generic Name: Brigatinib Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Brigatinib used for?

Brigatinib is used to treat a certain type of lung cancer (non-small cell lung cancer). It works by slowing or stopping the growth of cancer cells.

How should I take Brigatinib?

Take this medication by mouth with or without food as directed by your doctor, usually once daily. Swallow the tablets whole. Do not crush or chew the tablets.

The dosage is based on your medical condition, response to treatment, lab tests, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor may direct you to start this medication at a lower dose for one week and may then increase your dose. Follow your doctor’s instructions carefully.

If you vomit after taking a dose, do not take another dose at that time. Take your next dose on your usual dosing schedule.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

How do I store Brigatinib?

Brigatinib is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Brigatinib in the bathroom or the freezer. There may be different brands of Brigatinib that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Brigatinib down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Brigatinib?

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, other lung/breathing problems, heart disease (such as slow heartbeat), disease of the pancreas (pancreatitis), diabetes, vision problems.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using brigatinib. Brigatinib may harm an unborn baby. Ask your doctor about reliable forms of non-hormonal birth control (such as condoms, diaphragm with spermicide). Women using this medication should use non-hormonal birth control during treatment and for 4 months after stopping treatment. Men using this medication should use birth control during treatment and for 3 months after stopping treatment. If you or your partner become pregnant, talk to your doctor right away about the risks and benefits of this medication.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for 1 week after stopping this drug is not recommended. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Brigatinib during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Brigatinib. Brigatinib is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Brigatinib?

Nausea/vomiting, diarrhea, decreased appetite, abdominal pain, constipation, tiredness, dizziness, fever, headache, trouble sleeping, or joint pain may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: slow heartbeat, unusual tiredness, vision changes (such as blurred vision, double vision), increased thirst/urination, unusual muscle pain/tenderness/weakness, numbness/tingling of arms/legs, signs of pancreatitis (nausea/vomiting that doesn’t stop, stomach/abdominal pain).

Get medical help right away if you have any very serious side effects, including: symptoms of new or worsening lung problems (such as cough, shortness of breath, chest pain).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Brigatinib?

Other medications can affect the removal of brigatinib from your body, which may affect how brigatinib works. Examples include rifamycins (such as rifabutin), St. John’s wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

Brigatinib may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Brigatinib?

Brigatinib may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

This drug may make you dizzy or blur your vision. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Brigatinib?

Brigatinib may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Brigatinib.

What is the dose of Brigatinib for an adult?

Usual Adult Dose for Non-Small Cell Lung Cancer

-Initial Dose: 90 mg orally once a day for the first 7 days

-Maintenance Dose: If initial dose is tolerated during the first 7 days, increase to 180 mg orally once a day.

-Duration of Therapy: Until disease progression or unacceptable toxicity

Renal Dose Adjustments

Mild and Moderate Renal Impairment (CrCl 30 to 89 mL/min): No adjustment recommended.

Liver Dose Adjustments

Mild Hepatic Impairment (total bilirubin within upper limit of normal [ULN] and AST greater than ULN or total bilirubin greater than 1 and up to 1.5 x ULN and any AST): No adjustment recommended.

Dose Adjustments

Dosing interruption of 14 days or longer (for reasons other than adverse reactions): Resume treatment at 90 mg once a day for 7 days before increasing to the previously tolerated dose.

What is the dose of Brigatinib for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Brigatinib available?

Brigatinib is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Brigatinib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 16, 2018 | Last Modified: November 16, 2018

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