Generic Name: Bonefos Brand Name(s): Generics only. No brands available.


What is Bonefos® (sodium clodronate) used for?

Bonefos® is commonly used for treatment of hypercalcemia of malignancy, osteolytic bone metastases due to carcinoma of the breast and osteolytic lesions of multiple myeloma.

How should I take Bonefos® (sodium clodronate)?

Bonefos® 400 mg capsules should be swallowed whole. Bonefos® 800 mg tablet is scored and may be divided into two to ease swallowing, but the halves have to be taken at the same time of administration.

When taken as a single dose, Bonefos® should preferably be taken in the morning on an empty stomach together with a glass of plain water. If it is not possible to take the dose in the morning, Bonefos® should be taken more than two hours after eating or drinking (with the exception of plain water).

Bonefos® must not be taken with milk, food or drugs containing calcium and other divalent cations.

How do I store Bonefos® (sodium clodronate)?

Bonefos® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Bonefos® in the bathroom or the freezer. There may be different brands of Bonefos® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Bonefos® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Bonefos® (sodium clodronate)?

Before using this drug, you should know that:

  • This is particularly important when administering sodium clodronate to patients with hypercalcemia or renal failure.
  • Bonefos® tablets and capsules contain sodium which should be taken into account for patients on a low sodium diet or with renal disease.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Bonefos® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Bonefos®.

Side effects

What side effects can occur from Bonefos® (sodium clodronate)?

These side effects include:

  • Abdominal cramps
  • Confusion
  • Convulsions
  • Difficulty in breathing
  • Irregular heartbeats
  • Mood or mental changes
  • Muscle cramps in hands, arms, feet, legs, or face
  • Numbness and tingling around the mouth, fingertips, or feet
  • Shortness of breath
  • Tremor
  • Renal failure
  • Ulcerative pharyngitis

Those indicating need for medical attention only if they continue or are bothersome:

  • Incidence more frequent
    • Diarrhea (increased bowel movements; loose stools)
    • Gastric pain (tenderness in stomach area)
    • Nausea
    • Vomiting
  • Incidence less frequent or rare
    • Mouth irritation renal dysfunction (cloudy urine; decrease in urine output or decrease in urine-concentrating ability)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Bonefos® (sodium clodronate)?

Bonefos® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Bonefos® (sodium clodronate)?

Bonefos® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Bonefos® (sodium clodronate)?

Bonefos® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Bonefos® (sodium clodronate).

What is the dose of Bonefos® (sodium clodronate) for an adult?

A daily dose of 1600 mg can be taken either as a single dose or divided into two doses.

The duration of treatment is recommended to be life-long.

What is the dose of Bonefos® (sodium clodronate) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Bonefos® (sodium clodronate) available?

Bonefos® is available in the following dosage forms and strengths:

  • Table 300mg, 400mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Bonefos®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 21, 2017 | Last Modified: February 6, 2017

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