Betnovate Cream

By Medically reviewed by hellodoktor

Generic Name: Betnovate Cream Brand Name(s): Betnovate Cream.


What is Betnovate Cream® (betamethasone) used for?

Betnovate Cream® is commonly used for treating various types of skin infections such as eczema, psoriasis, or allergic reactions. It reduces the swelling, itching, and redness that can occur in these types of condition.

How should I take Betnovate Cream® (betamethasone)?

Taking Betnovate Cream® as directed by your doctor.

These directions are:

  • Applied Betnovate Cream® on the skin.
  • Consult your doctor before applying it on sensitive skin area like face, groin, underarms or for diaper rash.
  • Use this medication only for prescribed condition.
  • Do not use it for longer than prescribed.
  • Inform your doctor if your condition persists or worsens after 2 weeks.
  • Before applying the medication, you have to keep the affected skin clean and dry.
  • Apply a thin film of the medication to washed hands to the affected area and gently rub in.
  • Always keep the affected area clean and clear.
  • Do not cover, bandage, or wrap the area unless directed to do so by your doctor.
  • If you are using the lotion form of this medication, shake the bottle well before each dose.
  • Avoid getting it in the eyes as this may worsen or cause glaucoma. If you get the medication in these areas, rinse with plenty of water.
  • Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.

How do I store Betnovate Cream® (betamethasone)?

Betnovate Cream® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Betnovate Cream® in the bathroom or the freezer. There may be different brands of Betnovate Cream® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Betnovate Cream® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Betnovate Cream® (betamethasone)?

Before using Betnovate Cream®, tell your doctor if you have:

  • Allergies to excipients using for dosage form containing Betnovate Cream®.
  • Allergies to any other medicines, foods, dyes, preservatives, or animals.
  • Betnovate Cream® should not be used in children under 6 years of age without direction of a doctor.
  • Any medicines that you are taking, such as cancer chemotherapy agents, other topical medications, and vitamins, skin infection, diabetes, glaucoma, cataracts, a circulation disorder or an immune disorder.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Betnovate Cream® (betamethasone)?

When using Betnovate Cream®, you may experience some common side effects such as:

  • Burning, itching, or stinging at the application area
  • Hair loss or thinning of the hair
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • Irritation
  • Itching, scaling, severe redness, soreness, or swelling of the skin
  • Redness and scaling around the mouth
  • Thinning of the skin with easy bruising
  • Burning, crawling, itching, numbness, prickling or tingling feelings
  • Acne or pimples
  • Burning and itching of the skin with pinhead-sized red blisters
  • Burning, itching, and pain in hairy areas, or pus at the root of the hair
  • Increased hair growth on the forehead, back, arms, and legs
  • Lightening of normal skin color
  • Lightening of treated areas of dark skin
  • Reddish purple lines on the arms, face, legs, trunk, or groin
  • Softening of the skin

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Betnovate Cream® (betamethasone)?

Betnovate Cream® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Drugs may interact with Betnovate Cream® include:



ActoPlus Met, ActoPlus Met XR (metformin / pioglitazone)

Actos (pioglitazone)

Afrezza (insulin inhalation, rapid acting)



Amaryl (glimepiride)

Apidra, Apidra Solostar (insulin glulisine)

Avandamet (metformin / rosiglitazone)

Avandaryl (glimepiride / rosiglitazone)

Avandia (rosiglitazone)

Basaglar (insulin glargine)

Bydureon (exenatide)



DiaBeta (glyburide)

Insulin Lente Pork (insulin zinc)

Insulin lispro / insulin lispro protamine

Insulin Pork Mix (insulin isophane / insulin regular)

Insulin Purified NPH Pork (insulin isophane)

Insulin Purified Regular Pork (insulin regular)

Insulin zinc / Insulin zinc extended

Invokamet (canagliflozin / metformin)

Invokana (canagliflozin)

Janumet, Janumet XR (metformin / sitagliptin)

Januvia (sitagliptin)

Jardiance (empagliflozin)

Jentadueto, Jentadueto XR (linagliptin / metformin)

Juvisync (simvastatin / sitagliptin)

Kazano (alogliptin / metformin)

Kombiglyze XR (metformin / saxagliptin)

Lantus/ Lantus OptiClik Cartridge/ Lantus Solostar (insulin glargine)

Lente Iletin II (insulin zinc)

Levemir (insulin detemir)



Metaglip (glipizide / metformin)

Metformin / pioglitazone/ repaglinide/ rosiglitazone/ saxagliptin/ sitagliptin

Micronase (glyburide)


Saxenda (liraglutide)

Simvastatin / sitagliptin

Starlix (nateglinide)

Diabinese (chlorpropamide)

Duetact (glimepiride / pioglitazone)


Dymelor (acetohexamide)




Exubera (insulin inhalation, rapid acting)

Farxiga (dapagliflozin)

Fortamet (metformin)

Glimepiride / pioglitazone/rosiglitazone

Glipizide/ Glipizide XL

Glucophage/ Glucophage XR (metformin)

Glucotrol/Glucotrol XL (glipizide)

Glucovance (glyburide / metformin)

Glumetza (metformin)


Glycron (glyburide)

Glynase /Glynase PresTab (glyburide)

Glyset (miglitol)

Glyxambi (empagliflozin / linagliptin)

Humalog/Humalog KwikPen/ Humalog Mix 50 / 50 /Humalog Mix 50 / 50 KwikPen /Humalog Mix 50 / 50 Pen (insulin lispro / insulin lispro protamine)

Miglitol N


Nesina (alogliptin) Novolin 70 / 30, Novolin 70 / 30 Innolet, Novolin 70 / 30 PenFill (insulin isophane / insulin regular)

Novolin L (insulin zinc)

Novolin N, Novolin N Innolet, Novolin N PenFill (insulin isophane)

Novolin R, Novolin R Innolet, Novolin R PenFill (insulin regular)

Novolog, NovoLog FlexPen (insulin aspart)

NovoLog Mix 50 / 50 (insulin aspart / insulin aspart protamine)

NovoLog Mix 70 / 30, NovoLog Mix 70 / 30 FlexPen, Novolog Mix 70 / 30 PenFill (insulin aspart / insulin aspart protamine)

Toujeo Solostar (insulin glargine)

Tradjenta (linagliptin)

Tresiba (insulin degludec)


Trulicity (dulaglutide)

Velosulin BR (insulin regular)

Victoza (liraglutide)

Xigduo XR (dapagliflozin / metformin)

Synjardy (empagliflozin / metformin)

Tanzeum (albiglutide)

Tol-Tab (tolbutamide)


Tolinase (tolazamide)

Toujeo (insulin glargine)

Symlin/ Symlin Pen/ SymlinPen 120/ SymlinPen 60 (pramlintide)

Humalog Mix 75 / 25, Humalog Mix 75 / 25 KwikPen, Humalog Mix 75 / 25 Pen (insulin lispro / insulin lispro protamine)

Humalog Pen (insulin lispro)

Humulin 50 / 50, Humulin 70 / 30, Humulin 70 / 30 Pen (insulin isophane / insulin regular)

Humulin L (insulin zinc)

Humulin N, Humulin N Pen (insulin isophane)

Humulin R, Humulin R U-500, Humulin R U-500 KwikPen (insulin regular)

Humulin U (insulin zinc extended)

Iletin II Lente Pork (insulin zinc)

Iletin II NPH Pork (insulin isophane)

Iletin II Regular Pork (insulin regular)

Iletin Lente (insulin zinc)

Iletin NPH (insulin isophane)

Iletin Regular (insulin regular)

Insulin aspart/insulin aspart protamine

Insulin degludec

Insulin detemir

Insulin glargine

Insulin glulisine

Insulin inhalation, rapid acting

NovoLog PenFill (insulin aspart)

NPH Insulin (insulin isophane)

Onglyza (saxagliptin)

Orinase (tolbutamide)

Oseni (alogliptin / pioglitazone)


PrandiMet (metformin / repaglinide)

Prandin (repaglinide)

Precose (acarbose)

Relion Novolin 70 / 30 Innolet (insulin isophane / insulin regular)

Relion Novolin N (insulin isophane)

ReliOn / Humulin R (insulin regular)

ReliOn / Novolin 70 / 30 (insulin isophane / insulin regular)

ReliOn / Novolin R (insulin regular)


Rezulin (troglitazone)

Riomet (metformin)


Ryzodeg 70 / 30 (insulin aspart / insulin degl

Does food or alcohol interact with Betnovate Cream® (betamethasone)?

Betnovate Cream® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Betnovate Cream® (betamethasone)?

Betnovate Cream® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

You may need to tell your doctor before taking Betamethasone if you have:

  • Diabetes
  • Diaper Rash
  • Hyperadrenocorticism
  • Other infections
  • Ocular Toxicities


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Betnovate Cream® (betamethasone) for an adult?

Usual adult dose for dermatitis

  • Cream, gel, ointment: Apply a thin film to the affected area once or twice a day.
  • Foam, lotion: Apply twice a day (once in the morning and once at night).
  • Do not exceed 45 g per week.
  • If your condition does not improve after 2 weeks, seek for medical advice.

What is the dose of Betnovate Cream® (betamethasone) for a child?

Usual pediatric dose for dermatitis

For children aged from 12 years:

  • Cream, gel, ointment: Apply a thin film to the affected area once or twice a day.
  • Foam, lotion: Apply twice a day (once in the morning and once at night).
  • Do not exceed 45 g per week.
  • If your condition does not improve after 2 weeks, seek for medical advice.

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Betnovate Cream® (betamethasone) available?

Betnovate Cream® is available in the following dosage forms and strengths:

  • Betamethasone Dipropionate Lotion USP (Augmented), 0.05%
  • Betamethasone Dipropionate Cream (Augmented), 0.05%

What should I do in case of an emergency or overdose?

This medicine may be harmful if swallowed. In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Betnovate Cream®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: January 7, 2017 | Last Modified: September 12, 2019

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