Generic Name: Betagan Brand Name(s): Generics only. No brands available.


What is Betagan® (levobunolol) used for?

Betagan® ophthalmic solution has been shown to be effective in lowering intraocular pressure. It may be used in patients with chronic open-angle glaucoma or ocular hypertension.

Betagan® may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Betagan® (levobunolol)?

Use Betagan® drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Betagan® drops contains benzalkonium chloride, a preservative that may be absorbed by soft contact lenses. Contact lenses should be removed before using Betagan® drops. Ask your doctor or pharmacist how long you should wait to put your contacts back in after using Betagan® drops.

To use Betagan® drops:

  • Wash your hands.
  • Tilt your head back.
  • Using your index finger, pull the lower eyelid away from the eye to form a pouch.
  • Drop the medicine into the pouch and gently close your eyes.
  • Immediately use your finger to apply pressure to the inside corner of the eye (unless you recently had eye surgery) and continue to apply pressure for 1 or 2 minutes after using the medicine.
  • Do not blink. Keep your eyes closed for 1 or 2 minutes. Remove excess medicine around your eye with a clean tissue, being careful not to touch your eye.
  • Wash your hands to remove any medicine that may be on them.
  • To prevent germs from entering your medicine, do not touch the dropper tip to any surface, including your eye. Keep the container tightly closed.

Continue to use Betagan® drops even if you feel well. Do not miss any doses.

Ask your health care provider any questions you may have about how to use Betagan® drops.

How do I store Betagan® (levobunolol)?

Betagan® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Betagan® in the bathroom or the freezer. There may be different brands of Betagan® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Betagan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Betagan® (levobunolol)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Betagan® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Betagan® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Betagan®. Betagan® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Betagan® (levobunolol)?

Betagan® may cause following side effects, such as:

  • Temporary burning/stinging of the eye
  • Itchy/red eyes
  • Headache
  • Dizziness

Tell your doctor right away if any of these unlikely but serious side effects occur:

  • Eye pain/swelling/discharge
  • Reduced feeling in eye
  • Slow/irregular heartbeat
  • Muscle weakness
  • Hair loss
  • Mental/mood changes
  • Vision changes
  • Tiredness
  • Swelling of the ankles/feet
  • Sudden/unexplained weight gain
  • Chest pain
  • Slurred speech
  • Confusion
  • Serious allergic reaction, include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Betagan® (levobunolol)?

Betagan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Close observation of the patient is recommended when Betagan® is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope, or postural hypotension.
  • Patients receiving Betagan® along with either oral or intravenous calcium antagonists should be monitored for possible atrioventricular conduction disturbances, left ventricular failure and hypotension. In patients with impaired cardiac function, simultaneous use should be avoided altogether.
  • Taking Betagan® with digitalis and calcium antagonists may have additive effects on prolonging atrioventricular conduction time.
  • Phenothiazine-related compounds and Betagan® may have additive hypotensive effects due to the inhibition of each other’s metabolism.

Does food or alcohol interact with Betagan® (levobunolol)?

Betagan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Betagan® (levobunolol)?

Betagan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have or have ever had these medical health, such as:

  • Bronchitis
  • Breathing or lung problems
  • COPD
  • Diabetes
  • Overactive thyroid
  • Low blood sugar levels
  • Blood flow or blood vessel problems
  • A history of heart failure
  • First-degree heart block


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Betagan® (levobunolol) for an adult?

Open-angle Glaucoma

  • 25%: The recommended dose is 1-2 drops in affected eye(s) every 12 hours.
  • 5%: The recommended dose is 1-2 drops in affected eye(s) everyday, may increase to every 12 hours.

What is the dose of Betagan® (levobunolol) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Betagan® (levobunolol) available?

Betagan® is available in the following dosage forms and strengths:

  • Betagan® 0.25% 10 mL in 15 mL bottle
  • Betagan® 0.5% 5 mL in 10 mL bottle
  • Betagan® 0.5% 10 mL in 15 mL bottle
  • Betagan® 0.5% 15 mL in 15 mL bottle

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Betagan®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: May 25, 2017 | Last Modified: May 25, 2017

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