Arduan

By Medically reviewed by hellodoktor

Generic Name: Arduan Brand Name(s): Arduan.

Uses

What is Arduan® (pipercuronium bromide) used for?

Arduan® is commonly used for endotracheal intubation and relaxation of skeletal muscles in the course of general anesthesia during surgery, requiring more than 20-30 minutes of muscle relaxation.

How should I take Arduan® (pipercuronium bromide)?

The drug should be used only by injection, under the supervision of a qualified physician, having clinical experience of peripheral muscle relaxants.

How do I store Arduan® (pipercuronium bromide)?

Arduan® is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Arduan® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Arduan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Arduan® (pipercuronium bromide)?

Before using this drug, you should know that:

  • The drug should be used only in a specialized hospital with the appropriate equipment for artificial respiration and in the presence of a specialist to conduct artificial respiration.
  • Careful monitoring of the maintenance of vital functions during surgery and in the early postoperative period until the full restoration of adequate vitality.
  • When calculating, the dose should be considered to apply the technique of anesthesia, the possible interaction with other drugs, administered before or during anesthesia, the state and the individual patient’s sensitivity to the drug.
  • Doses, causing muscle relaxation, not have a significant cardiovascular effect and in most cases do not cause bradycardia.
  • The need for the appointment and dosing regimen vagolytic preparations for premedication should first carefully consider.
  • To prevent relative overdose and to ensure appropriate monitoring recovery of muscle, activity is recommended to use a peripheral nerve stimulator.
  • Patients with disorders of neuromuscular transmission, obesity, renal failure, for violations of the liver and / or biliary tract, or if a history of myocardial indicate polio, the drug should be prescribed in smaller doses.
  • If abnormal liver function Arduan®, the application is possible only in cases, when the intended benefits to the patient outweighs the potential risk. When this drug should be used in the minimum effective dose.
  • When overweight and obesity may increase the duration of Arduan®, therefore the dose should be used, designed for ideal weight.
  • Observe extreme caution, applying Arduan® with a history of anaphylactic reactions, caused by muscle relaxants, because of the possible development of cross-hypersensitivity.
  • There are effects on ability to drive vehicles and management mechanisms.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Arduan® (pipercuronium bromide)?

Some side effects could occur when using this drug, such as:

  • Depression
  • Weakness of the skeletal muscles
  • Gipnoe
  • Apnea
  • Pulmonary atelectasis
  • Respiratory depression
  • Laryngospasm due to an allergic reaction
  • Myocardial ischemia (until myocardial infarction) and brain
  • Atrial fibrillation
  • Ventricular premature beats
  • Bradycardia
  • Decrease in blood pressure
  • Thrombosis
  • Decrease in a PTT and prothrombin time
  • Hypercreatininemia
  • Anurija
  • Hypoglycemia
  • Hyperkalemia
  • Skin rash
  • Hypersensitivity reactions
  • Angioedema

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Arduan® (pipercuronium bromide)?

Arduan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Acetylcholinesterase inhibitors
  • Inhaled anesthetics
  • Muscle relaxants nedepolyariziruyuschie
  • Antibiotics and chemotherapy drugs
  • Diuretics
  • Alpha- and beta-blockers
  • Tiaminom
  • MAO inhibitors
  • Guanidine
  • Protamine
  • Phenytoin
  • Blockers of slow calcium channels
  • Magnesium salts
  • Lidocaine
  • Corticosteroids
  • Neostigmine
  • Pyridostigmine
  • Azathioprine
  • Teofillina
  • Epinephrine
  • Potassium chloride
  • Sodium chloride

Does food or alcohol interact with Arduan® (pipercuronium bromide)?

Arduan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Arduan® (pipercuronium bromide)?

Arduan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Arduan® (pipercuronium bromide).

What is the dose of Arduan® (pipercuronium bromide) for an adult?

The initial dose intubation and subsequent surgery is 80-100 ug / kg body weight, provides good or excellent conditions for intubation 150-180 sec. The duration of neuromuscular blockade is 60-90 minutes.

For muscle relaxation during surgery after intubation with succinylcholine, the initial dose is 50 ug / kg of body weight provides the 30-60 minute miorelaxation.

The maintenance dose is 10-20 ug / kg – provides 30-60 minute miorelaxation.

At chronic renal failure, the dose should be calculated, according to the CC.

What is the dose of Arduan® (pipercuronium bromide) for a child?

Children aged 3 months before 1 year, the drug should be used in the calculation 40 ug / kg body weight (providing muscle relaxation duration from 10 to 44 m).

Children from 1 year to 14 years, the dose is 57 mg / kg (muscle relaxation provided by the duration 18 to 52 m).

How is Arduan® (pipercuronium bromide) available?

Arduan® is available in the following dosage forms and strengths:

  • Injectable; Injection; Pipecuronium Bromide 10 mg
  • Injectable; Injection; Pipecuronium Bromide 4 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

Symptoms of overdoes are prolonged paralysis of skeletal muscle, apnea, marked reduction in blood pressure.

What should I do if I miss a dose?

Ask your doctor for more information.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: February 17, 2017 | Last Modified: September 13, 2019

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