Anti-D Immunoglobulin

By Medically reviewed by hellodoktor

Generic Name: Anti-D Immunoglobulin Brand Name(s): Anti-D Immunoglobulin and Anti-D Immunoglobulin.


What is Anti-D Immunoglobulin used for?

Anti-D Immunoglobulin is commonly used for preventing blood-type incompatibility during pregnancy or blood transfusions. Anti-D (rh) immunoglobulin can also be used to treat immune thrombocytopenia purpura (ITP), a bleeding disorder, in adults.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

How should I take Anti-D Immunoglobulin?

This medication is available in an injectable form to be given directly into a muscle (IM) or a vein (IV) by a healthcare professional.

How do I store Anti-D Immunoglobulin?

Anti-D Immunoglobulin is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Anti-D Immunoglobulin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Anti-D Immunoglobulin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Anti-D Immunoglobulin?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Anti-D Immunoglobulin or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You are Rh-positive.

Anti-D (rh) immunoglobulin can also cause dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Anti-D Immunoglobulin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Anti-D Immunoglobulin. Anti-D Immunoglobulin is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Anti-D Immunoglobulin?

The most common side effect is injection site reactions that may include swelling, induration, redness, and mild pain or warmth.

Common side effects of anti-D (rh) immunoglobulin for prevention of Rh immunization include:

  • Nausea
  • Dizziness
  • Headache
  • Injection-site pain
  • Malaise

Common side effects of anti-D (rh) immunoglobulin for treatment of ITP include:

Serious side effects have been reported with anti-D (rh) immunoglobulin including the following:

  • Intravascular hemolysis (IVH). IVH is a serious blood problem. Tell your healthcare provider right away if you have some or all of the following symptoms of IVH: back pain, shaking chills, a fever, dark urine, a decreased amount of urine, a sudden, weight gain, swelling of the hands or feet, shortness of breath
  • Allergic reactions, including anaphylaxis. Tell your healthcare provider right away if you have some or all of the following symptoms of an allergic reaction: itching, a rash, hives, chest pain, dizziness or lightheadedness, trouble breathing, any swelling of your hands, face, or mouth.
  • Blood clots. Tell your healthcare provider right away if you have some or all of the following symptoms of a blood clot: chest pain, shortness of breath, a severe headache, leg pain, problems with vision, speech, or walking.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Anti-D Immunoglobulin?

Anti-D Immunoglobulin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Anti-D (rh) immunoglobulin may impair the efficacy of live vaccines such as measles, mumps, and varicella. Administration of live vaccines should generally be delayed until 12 weeks after the final dose of anti-D (rh) immunoglobulin. If Anti-D (rh) immunoglobulin is administered within 14 days after administration of a live vaccine, the efficacy of the vaccination may be impaired. The postpartum vaccination of rubella-susceptible women with rubella or MMR vaccine should not be delayed because of the receipt of anti-D (rh) immunoglobulin.

Does food or alcohol interact with Anti-D Immunoglobulin?

Anti-D Immunoglobulin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Anti-D Immunoglobulin?

Anti-D Immunoglobulin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Anemia
  • Blood clotting problems
  • Breathing problems
  • Kidney problems
  • Pulmonary edema (fluid in the lungs)
  • Atherosclerosis (hardening of the arteries)
  • Heart or blood vessel problems
  • Hyperviscosity (thick blood)
  • A stroke
  • Diabetes


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Anti-D Immunoglobulin.

What is the dose of Anti-D Immunoglobulin for an adult?


Transfusion of D-positive blood components to rhesus-negative women of child-bearing potential

Adult: 125 units/ml of transferred cells.


Prevent formation of antibodies against fetal rhesus-positive RBCs in a rhesus-negative mother during childbirth, abortion or certain other sensitising events

Adult: 500 units as soon as possible after birth. An additional dose may be required depending on the amount of transplacental bleeding as assessed by the Kleihauer test; for bleeds >4 ml, an additional 125 units for each ml of RBCs will be required.


Routine antenatal prophylaxis

Adult: 2 doses of 500 units to be given at wk 28th and 34th of gestation.


Idiopathic thrombocytopenic purpura

Adult: Initially, 250 units/kg, may be given in 2 divided doses on separate days. Maintenance doses: 125-300 units/kg depending on the clinical response.

What is the dose of Anti-D Immunoglobulin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Anti-D Immunoglobulin available?

Anti-D Immunoglobulin is available in the following dosage forms and strengths:

  • Injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Anti-D Immunoglobulin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: October 12, 2017 | Last Modified: September 12, 2019

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