Anistreplase

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Generic Name: Anistreplase Brand Name(s): Anistreplase.

Uses

What is anistreplase used for?

Anistreplase is commonly used for preventing blood from clotting. Studies have shown this medication to be effective in reducing the risk of death following an acute heart attack.

How should I take anistreplase?

This medication is given by injection into a vein as soon as possible after heart attack symptoms occur. It will be given by a health care professional who will closely monitor your therapy.

How do I store anistreplase?

Anistreplase is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of anistreplase that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush anistreplase down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using anistreplase?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of anistreplase or other medications.
  • You have any other illnesses, disorders, or medical conditions.

This drug should not be used when the following conditions are present: bleeding, blood vessel abnormalities, brain tumor, history of stroke, recent surgery, extremely high blood pressure (200/120 or higher).

This drug should be used with caution when the following conditions exist: childbirth within the last 10 days, blood clotting problems, endocarditis, recent retinal bleeding, recent gastrointestinal or urinary tract bleeding, ulcers, very high blood pressure (180/110), a recent invasive procedure, if you have ever had a synthetic graft placed (knitted Dacron), heart abnormalities.

This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using anistreplase during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking anistreplase. Anistreplase is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from anistreplase?

Bleeding and irregular heart rhythms may occur as a result of this drug. You will be monitored closely for signs of these effects.

Notify your doctor of: itching, flushing, skin rash, fever, chills, headache, nausea, sweating, dizziness, muscle aches or tremor.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with anistreplase?

Anistreplase may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Corticosteroids (e.g., prednisone)
  • Aspirin (or drugs related to aspirin)
  • “blood thinners” (e.g., warfarin, heparin)
  • Aminocaproic acid
  • Drugs used for high blood pressure
  • Valproic acid
  • Injectable cephalosporins
  • Drugs used for arthritis (NSAID such as ibuprofen and naproxen)
  • Sulfinpyrazone

Does food or alcohol interact with anistreplase?

Anistreplase may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with anistreplase?

Anistreplase may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using anistreplase.

What is the dose of anistreplase for an adult?

Acute coronary arterial thrombosis during an acute MI. Adults: 30 units by direct I.V. injection over 2 to 5 minutes

What is the dose of anistreplase for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is anistreplase available?

Anistreplase is available in the following dosage forms and strengths:

  • Injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of anistreplase, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 10, 2017 | Last Modified: October 10, 2017

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