Anexate

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Generic Name: Anexate Brand Name(s): Generics only. No brands available.

Uses

What is Anexate® (flumazenil) used for?

Anexate® is a benzodiazepine antagonist. It works by blocking receptors in the brain and central nervous system that benzodiazepines need to reach to be active, which helps reduce drowsiness and sedation.

How should I take Anexate® (flumazenil)?

It comes as a solution for injection, to be administered by a healthcare provider into the vein.

How do I store Anexate® (flumazenil)?

Anexate® is usually handled and stored by a health care provider. If you are using Anexate® at home, store Anexate® as directed by your pharmacist or health care provider. Keep Anexate® out of the reach of children and away from pets.

You should not flush Anexate® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Anexate® (flumazenil)?

Do not use Anexate® if:

  • You are allergic to any ingredient in Anexate® or to benzodiazepines (e.g., alprazolam).
  • You have been given a benzodiazepine for control of a potentially life-threatening condition (e.g., increased pressure in the head, seizures).
  • You are experiencing side effects due to an overdose of a medicine used to treat depression.
  • You are taking any prescription or nonprescription medicine (especially benzodiazepines), herbal preparation, or dietary supplement.

Contact your doctor or health care provider right away if any of these apply to you.

Is it safe during pregnancy or breastfeeding?

Pregnancy

There isn’t enough information about the safety of using Anexate® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Anexate®.

Breastfeeding:

It is unknown if Anexate® is excreted in breast milk. If you are or will be breastfeeding while you are using Anexate®, check with your doctor or pharmacist to discuss the risks to your baby.

Side effects

What side effects can occur from Anexate® (flumazenil)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Abnormal or blurred vision
  • Abnormal skin sensations
  • Changes in vision
  • Clumsiness
  • Dizziness
  • Dry mouth
  • Feeling of a whirling motion
  • Flushing
  • General body discomfort
  • Headache
  • Hot flashes
  • Increased sweating
  • Nausea
  • Nervousness
  • Pain at the injection site
  • Restlessness
  • Sleeplessness
  • Sweating
  • Tiredness
  • Tremors
  • Vomiting
  • Weakness

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Agitation
  • Change in behavior, mood, or emotions (e.g., anxiety, depression)
  • Pounding in the chest
  • Rapid deep breathing
  • Seizures

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Anexate® (flumazenil)?

Anexate® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Anexate® (flumazenil)?

Anexate® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Anexate® (flumazenil)?

Anexate® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • A history of seizures
  • Panic disorder
  • Liver problems
  • Alcohol or other substance abuse
  • Recent head injury

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Anexate® (flumazenil).

What is the dose of Anexate® (flumazenil) for an adult?

Anesthesia

The recommended starting dose is 0.2 mg administered intravenously over 15 seconds.

The usual dose is 0.3 to 0.6 mg, but may deviate depending on the patient’s characteristics and the benzodiazepine used.

Intensive care

The recommended starting dose is 0.2 mg administered intravenously over 15 seconds.

If drowsiness recurs, a second bolus injection of Anexate® may be administered. An intravenous infusion of 0.1 – 0.4 mg/h may be useful.

Infusion should be discontinued every 6 hours to verify whether re-sedation occurs.

Elderly

In the absence of data on the use of Anexate® in elderly patients, it should be noted that this population is generally more sensitive to the effects of medicinal products and should be treated with due caution.

Patients with renal or hepatic impairment

Since Anexate® is primarily metabolised in the liver, careful titration of dosage is recommended in patients with impaired hepatic function. No dosage adjustments are required in patients with renal impairment.

What is the dose of Anexate® (flumazenil) for a child?

Children above 1 year of age

The recommended initial dose is 0.01 mg/kg (up to 0.2 mg) administered intravenously over 15 seconds.

Children under the age of 1 year

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Anexate® (flumazenil) available?

Anexate® is available in the following dosage forms and strengths:

  • Intravenous solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Anexate®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: January 21, 2017 | Last Modified: February 6, 2017

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