Anastrozole

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Generic Name: Anastrozole Brand Name(s): Anastrozole.

Uses

What is anastrozole used for?

Anastrozole is commonly used for treating breast cancer in women after change of life. It may be given to you for other reasons. Talk with the doctor.

How should I take anastrozole?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

Take with or without food.

Keep taking anastrozole as you have been told by your doctor or other health care provider, even if you feel well.

To gain the most benefit, do not miss doses.

How do I store anastrozole?

Anastrozole is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store anastrozole in the bathroom or the freezer. There may be different brands of anastrozole that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush anastrozole down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

 

Precautions & warnings

What should I know before using anastrozole?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of anastrozole or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have not been through menopause or you are still able to have a baby.
  • You are taking any of these drugs: Estrogen products or tamoxifen.

Tell all of your health care providers that you take anastrozole. This includes your doctors, nurses, pharmacists, and dentists.

Have a bone density test as you have been told by your doctor. Talk with your doctor.

Have blood work checked as you have been told by the doctor. Talk with the doctor.

This medicine lowers the estrogen in your body, which may cause your bones to get thinner and weaker. This may raise the chance of broken bones like in the spine, hip, and wrist. Talk with your doctor.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using anastrozole during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking anastrozole. Anastrozole is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from anastrozole?

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes
  • Signs of high calcium levels like weakness, confusion, feeling tired, headache, upset stomach and throwing up, hard stools (constipation), or bone pain
  • Shortness of breath, a big weight gain, or swelling in the arms or legs
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm
  • Very bad headache
  • A burning, numbness, or tingling feeling that is not normal
  • Chest pain or pressure
  • A heartbeat that does not feel normal
  • Mood changes
  • Very bad dizziness or passing out
  • Passing urine more often
  • Pain when passing urine
  • Feeling very tired or weak
  • Swollen gland
  • Vaginal bleeding that is not normal
  • Vaginal itching or discharge

People who have ever had a block in their heart blood vessels (ischemic heart disease) may have more signs of problems with blood flow to the heart. Call your doctor right away if you have new or worse chest pain or shortness of breath.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with anastrozole?

Anastrozole may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with anastrozole?

Anastrozole may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with anastrozole?

Anastrozole may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using anastrozole.

 

What is the dose of anastrozole for an adult?

Usual Adult Dose for Breast Cancer

Initial dose: 1 mg orally taken once a day

Duration of therapy: Until tumor progression (treatment of advanced breast cancer); unknown (adjuvant treatment of early breast cancer)

Uses:

  • Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer;
  • First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer;
  • Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

What is the dose of anastrozole for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is anastrozole available?

Anastrozole is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of anastrozole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

 

Sources

Review Date: October 9, 2017 | Last Modified: October 9, 2017

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