Anagrelide

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Generic Name: Anagrelide Brand Name(s): Generics only. No brands available.

Uses

What is anagrelide used for?

Anagrelide is commonly used to lower platelet count.

How should I take anagrelide?

Use anagrelide as ordered by your doctor. Read all information given to you. Follow all instructions closely.

Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.

To gain the most benefit, do not miss doses.

How do I store anagrelide?

Anagrelide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store anagrelide in the bathroom or the freezer. There may be different brands of anagrelide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush anagrelide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using anagrelide?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of anagrelide or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have any of these health problems: Liver disease or low potassium levels.
  • You have ever had a long QT on ECG or other heartbeat that is not normal.
  • You are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.

Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.

Have blood work checked as you have been told by the doctor. Talk with the doctor.

You will need to have your heart checked before starting anagrelide. This includes an ECG. Talk with your doctor.

You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.

Other drugs that work like this one have led to more deaths in people with very bad heart failure compared to people with very bad heart failure not taking those drugs. Talk with the doctor.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using anagrelide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking anagrelide. Anagrelide is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from anagrelide?

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop
  • Signs of lung or breathing problems like shortness of breath or other trouble breathing, cough, or fever
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight
  • Chest pain or pressure or a fast heartbeat
  • A heartbeat that does not feel normal
  • Shortness of breath, a big weight gain, or swelling in the arms or legs
  • Very bad dizziness or passing out
  • Very bad headache
  • Feeling very tired or weak
  • Change in eyesight
  • Not able to pass urine or change in how much urine is passed
  • Low mood (depression)
  • Feeling confused
  • Memory problems or loss
  • A burning, numbness, or tingling feeling that is not normal
  • Seizures

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with anagrelide?

Anagrelide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with anagrelide?

Anagrelide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with anagrelide?

Anagrelide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using anagrelide.

What is the dose of anagrelide for an adult?

Usual Adult Dose for Thrombocythemia

Initial: 0.5 mg orally 4 times a day, or 1 mg orally twice a day, for a minimum of 7 days.

Maintenance: titrate to the lowest effective dosage required to reduce and maintain the platelet count at less than 600,000 cells/microliter, ideally down to normal levels. Increase the dosage by no more than 0.5 mg/day in any 1 week period.

The dosage should not exceed 10 mg/day or 2.5 mg in any single dose.

What is the dose of anagrelide for a child?

Usual Pediatric Dose for Chronic Myelogenous Leukemia

Initial dose: 0.5 mg orally daily (recommended) to 0.5 mg orally 4 times daily.

Maintenance: titrate to the lowest effective dosage required to reduce and maintain the platelet count at less than 600,000 cells/microliter, ideally down to normal levels. Increase the dosage by no more than 0.5 mg/day in any 1 week period.

The dosage should not exceed 10 mg/day or 2.5 mg in any single dose.

Usual Pediatric Dose for Thrombocythemia

Initial dose: 0.5 mg orally daily (recommended) to 0.5 mg orally 4 times daily.

Maintenance: titrate to the lowest effective dosage required to reduce and maintain the platelet count at less than 600,000 cells/microliter, ideally down to normal levels. Increase the dosage by no more than 0.5 mg/day in any 1 week period.

The dosage should not exceed 10 mg/day or 2.5 mg in any single dose.

How is anagrelide available?

Anagrelide is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of anagrelide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 9, 2017 | Last Modified: October 9, 2017

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