Amsacrine

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Generic Name: Amsacrine Brand Name(s): Generics only. No brands available.

Uses

What is amsacrine used for?

Amsacrine is an antineoplastic agent, prescribed for malignant lymphoma and acute adult lymphoblastic leukemia. It is usually given in combination with other chemotherapy drugs

How should I take amsacrine?

It comes as a red colored solution for injection to be administered by a healthcare provider into the vein.

How do I store amsacrine?

Amsacrine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amsacrine in the bathroom or the freezer. There may be different brands of amsacrine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amsacrine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amsacrine?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of amsacrine or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Caution should be exercised in patients with liver or kidney diseases, with low levels of potassium in their blood, who have already had treatment with other types of anticancer medications, during pregnancy and breastfeeding.

Monitor complete blood counts, electrolyte for each treatment, heart, liver, kidney and CNS function regularly.

Not to be used in people with a severe reduction in blood cell production by the bone marrow.

This medicine is not recommended for children under 12 years old.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using amsacrine during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking amsacrine.

Side effects

What side effects can occur from amsacrine?

Most common side effects include fatigue (tiredness), sore mouth and throat, loss of fertility, absence of menstrual period, decrease in the number of healthy white blood cells, red blood cells or platelets in the blood.

Other side effects are hair loss, abdominal pain, pain and swelling at injection site, nausea, vomiting, diarrhea, fever, infections, convulsions, disturbances in liver function, jaundice, acute kidney failure, blood in the urine, abnormal heart beats, heart failure or heart attack.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with amsacrine?

Amsacrine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with amsacrine?

Amsacrine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amsacrine?

Amsacrine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using amsacrine.

What is the dose of amsacrine for an adult?

IV- Adult: Induction: 90 mg/m2/day for 5-8 days, may increase to 120 mg/m2/day.

What is the dose of amsacrine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is amsacrine available?

Amsacrine is available in the following dosage forms and strengths:

  • Injectable solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of amsacrine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: October 6, 2017 | Last Modified: October 6, 2017

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